A5024549935- Pancreatic function and diabetes
- Renin-Angiotensin System Studies
- Hormonal Regulation and Hypertension
- Apelin-related biomedical research
- Diabetes and associated disorders
- Diabetes Treatment and Management
- Pancreatitis Pathology and Treatment
- Receptor Mechanisms and Signaling
- Neuroscience of respiration and sleep
- Adipose Tissue and Metabolism
- Fibroblast Growth Factor Research
- Neuropeptides and Animal Physiology
- Metabolism, Diabetes, and Cancer
- Neuroendocrine regulation and behavior
- Diet, Metabolism, and Disease
- Ion Transport and Channel Regulation
- Cancer Mechanisms and Therapy
- Birth, Development, and Health
- Liver Disease Diagnosis and Treatment
- High Altitude and Hypoxia
- Diabetes Management and Research
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Kruppel-like factors research
- Epigenetics and DNA Methylation
Chinese University of Hong Kong
2013-2022
GTx (United States)
2019-2020
University of Hong Kong
2015-2017
Boehringer Ingelheim (Germany)
2015
Boehringer Ingelheim (China)
2015
Prince of Wales Hospital
2014
Hong Kong Jockey Club
2011
Jinan University
2011
Shatin Hospital
2004
National Institute for Environmental Studies
1995
We identified an angiotensin-generating system in pancreatic islets and found that exogenously administered angiotensin II, after binding to its receptors (angiotensin II type 1 receptor [AT1R]), inhibits insulin release a manner associated with decreased islet blood flow (pro)insulin biosynthesis. The present study tested the hypothesis there is change AT1R expression of obesity-induced 2 diabetes model, db/db mouse, which enables endogenous levels impair function. Islets from 10-week-old...
Circulating fibroblast growth factor 21 (FGF21) levels are elevated in diabetic subjects and correlate directly with abnormal glucose metabolism, while pharmacologically administered FGF21 can ameliorate hyperglycemia. The pancreatic islet is an target, yet the actions of under normal conditions not fully understood. This study investigated effects high on a mouse model by investigating db/db responses to exogenous FGF21, direct signaling, involvement peroxisome proliferator-activated...
The novel sodium glucose co-transporter 2 (SGLT2) inhibitor empagliflozin has recently been reported to improve glycemic control in streptozotocin-induced type 1 diabetic rats an insulin-independent manner, via increase urinary output. We investigated the potential of recover insulin pathways diabetes by improving pancreatic β-cell mass. Blood homeostasis was assessed intraperitoneal tolerance test. Serum levels and mRNA expression were determined using commercial ELISA kits real-time...
Abstract Fibroblast growth factor (FGF) 21 is an endocrine that normalizes glucose homeostasis and reduces insulin resistance in diabetes. Although the pancreas FGF21 target organ, its role pancreatic islets remains obscure. This study aimed to elucidate physiological of using FGF21-knockout (FGF21-KO) mice. Twenty-four-week-old male global FGF21-KO mice were used this study. Glucose tolerance assessed. Expression genes proteins related islet function underlying mechanisms also examined....
Secretin was the first hormone discovered in human history, and yet, its function as a neuropeptide has been overlooked past. The recent discovery of potential use secretin treating autistic patients, together with conflicting reports on effectiveness, urges an in-depth investigation this issue. We show here that rat cerebellar cortex, mRNAs encoding are localized Purkinje cells, whereas those receptor found both cells GABAergic interneurons. Immunoreactivity for is soma dendrites cells. In...
New Findings What is the central question of this study? Expression renin–angiotensin system (RAS) may play a pathogenic role in augmented activity carotid body chemosensitive cells and (CB) inflammation chronic intermittent hypoxia (IH). The aim study was to examine expression function RAS components CB during IH resembling severe sleep‐apnoeic condition. main finding its importance? Chronic induces functional upregulation CB. could excitability IH, which relevant early pathogenesis...