A5102762487- Pancreatic function and diabetes
- Fibroblast Growth Factor Research
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Diabetes and associated disorders
- Diabetes Treatment and Management
- Genetics and Neurodevelopmental Disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet, Metabolism, and Disease
- Kruppel-like factors research
- Adipose Tissue and Metabolism
- Genetic Associations and Epidemiology
- Birth, Development, and Health
- Cardiovascular Health and Risk Factors
- Diabetes Management and Research
- Diet and metabolism studies
- Hormonal Regulation and Hypertension
- Gestational Diabetes Research and Management
- Long-Term Effects of COVID-19
- Peroxisome Proliferator-Activated Receptors
- Heme Oxygenase-1 and Carbon Monoxide
- Primary Care and Health Outcomes
- Endoplasmic Reticulum Stress and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Insect and Arachnid Ecology and Behavior
University of Tartu
2025
Institute of Molecular and Cell Biology
2021-2024
Agency for Science, Technology and Research
2021-2024
Singapore Bioimaging Consortium
2021
Chinese University of Hong Kong
2003-2019
Prince of Wales Hospital
1996-2014
University of Hong Kong
2014
Short-term follow-up studies of severe acute respiratory syndrome (SARS) survivors suggested that their physical conditions continuously improved in the first year but mental health did not. We investigated long-term psychiatric morbidities and chronic fatigue among SARS survivors.All from hospitals a local region Hong Kong were assessed by constellation psychometric questionnaires semistructured clinical interview for Diagnostic Statistical Manual Mental Disorders (Fourth Edition) to...
Circulating fibroblast growth factor 21 (FGF21) levels are elevated in diabetic subjects and correlate directly with abnormal glucose metabolism, while pharmacologically administered FGF21 can ameliorate hyperglycemia. The pancreatic islet is an target, yet the actions of under normal conditions not fully understood. This study investigated effects high on a mouse model by investigating db/db responses to exogenous FGF21, direct signaling, involvement peroxisome proliferator-activated...
Abstract Fibroblast growth factor (FGF) 21 is an endocrine that normalizes glucose homeostasis and reduces insulin resistance in diabetes. Although the pancreas FGF21 target organ, its role pancreatic islets remains obscure. This study aimed to elucidate physiological of using FGF21-knockout (FGF21-KO) mice. Twenty-four-week-old male global FGF21-KO mice were used this study. Glucose tolerance assessed. Expression genes proteins related islet function underlying mechanisms also examined....
Fibroblast growth factor 21 (FGF21) is known as a potent metabolic regulator but its protective mechanisms against lipotoxicity-induced β-cell dysfunction and apoptosis remain elusive. Here, we aimed to examine the regulatory pathways whereby FGF21 mediates islet lipid metabolism in lipotoxicity-treated cells animal models. Rat line (INS-1E cells) islets isolated from C57/BL6J mice were exposed palmitic acid (PA) with/without FGF21, mimicking lipotoxic conditions. Resultant insulin secretion...
In recent decades, chimeric antigen receptor (CAR)-engineered immune effector cells have demonstrated promising antileukemic activity. Nevertheless, their efficacy remains unsatisfactory on solid cancers, plausibly due to the influence of tumor microenvironments (TME). a novel mouse cancer model with humanized system, tumor-infiltrating immunosuppressive leukocytes and exhausted programmed death protein-1 (PD-1)high T were found, which better mimic patient TME, allowing screening assessment...
Background: Emerging evidence suggests a significant correlation between pancreatitis and gut microbiota, yet the causal relationship underlying mechanism remain largely undetermined. Given that microbiota plays crucial role in regulating circulating metabolites, we aimed to elucidate how these interactions impact risk of acute (AP).Methods: Using two-sample Mendelian randomization (MR) analysis, investigated links among plasma AP. Enrichment analysis was performed determine primary...
Loss of functional beta cells is the central event all forms diabetes. Conventional therapies for type 2 diabetes (T2D) fail to preserve cells, leading worsening glycemia as cell function progressively declines. While immunotherapies 1 (T1D) have been unsuccessful, emerging evidence suggests that revitalize are essential reverse T1D. Islet transplantation represents a promising replacement therapy. However, its widespread application limited by scarcity available islets and post-transplant...
Abstract COP1 and COP9 signalosome (CSN) are the substrate receptor deneddylase of CRL4 E3 ligase, respectively. How they functionally interact remains unclear. Here, we uncover COP1–CSN antagonism during glucose-induced insulin secretion. Heterozygous Csn2 WT/K70E mice with partially disrupted binding IP 6 , a CSN cofactor, display congenital hyperinsulinism resistance. This is due to increased Cul4 neddylation, assembly, ubiquitylation ETV5, an obesity-associated transcriptional suppressor...
Background Many risk factors for cardiovascular disease (CVD) have been identified. Recently, an association between low concentration of serum bilirubin and increased CVD has reported. However, information on this topic remains scarce. Methods We examined the relationships in 1508 Hong Kong Chinese. divided subjects into four quartiles based concentrations. Cardiovascular studied include age, sex, smoking, obesity, glycaemic status lipid indices. Results Decreasing was associated with older...
Abstract Aim To investigate the relationship between birthweight and cardiometabolic traits in two cohorts: one of Chinese adolescents adults. Methods Birthweight clinical data, including anthropometric traits, fasting plasma glucose insulin levels, blood pressure lipid profiles were collected from 2035 456 A subset 735 subjects underwent an oral tolerance test to measure concentrations at 0, 15, 30, 60 120 min. Results Among adolescents, showed U‐shaped relationships with larger body size,...
G-protein-coupled receptor 120 (GPR120) is a putative target for obesity and diabetes therapies. However, it remains controversial whether resident GPR120 plays direct regulatory role in islet β-cell insulin secretion. The present study examined this issue isolated rodent islets rat line INS-1E, assessed the of secretion obese non-diabetic (OND) diabetic states. expression was detected β-cells. Docosahexaenoic acid (DHA) synthetic agonist GSK137647 (GSK) augmented release from rat/mouse...
The paired box 6 (PAX6) transcription factor is crucial for normal pancreatic islet development and function. Heterozygous mutations of PAX6 are associated with impaired insulin secretion early-onset diabetes mellitus in humans. However, the molecular mechanism controlling human beta cells its pathophysiological role type 2 (T2D) remain ambiguous. We investigated pathway regulation potential therapeutic value T2D by using cell line EndoC-βH1, db/db mouse model, primary islets. Through loss-...
<b>Background:</b> A recently halted clinical trial showed that intensive treatment of type 2 diabetes mellitus was associated with increased mortality. Given the phenotypic heterogeneity diabetes, therapy targeted at insulin status may maximize benefits and minimize harm. <b>Methods:</b> In this longitudinal cohort study, we followed 503 patients who were free cardiovascular disease from 1996 until data on mortality outcomes censored in 2005. Phenotype-targeted defined as use a fasting...
Positive family history is associated with increased type 2 diabetes (T2D) risk, and reflects both genetic environmental risks. Several studies have suggested an excess maternal transmission of T2D, although the underlying mechanism unknown. We aimed to examine association between cardiometabolic risk in offspring. Parental clinical data including anthropometric traits, fasting plasma glucose insulin (FPG, FPI), blood pressure lipid profile were collected from 2581 unrelated Chinese...
Increased plasma glucose concentration is a predictive factor for mortality in both diabetic and non-diabetic subjects. Although glycated haemoglobin (HbA1c) useful index of mean blood concentrations over the preceding 1 to 3 months, there are few data regarding its relationship cardiovascular risk. We have examined between HbA1c risk factors 1280 subjects with normal tolerance. Based on tertiles (tertile 1: n = 427, 262 men 165 women, level: 2.9–4.7 % 3.2–4.2 women; tertile 2: 426, 261...
Abstract Loss of pancreatic beta cells is the central feature all forms diabetes. Current therapies fail to halt declined cell mass. Thus, strategies preserve are imperatively needed. In this study, we identified paired box 6 (PAX6) as a critical regulator survival. Under diabetic conditions, human line EndoC‐βH1, db/db mouse and islets displayed dampened insulin incretin signalings reduced survival, which were alleviated by PAX6 overexpression. Adeno‐associated virus (AAV)‐mediated...
Objective: To report a case of clozapine-induced hypertension with raised urinary catecholamines. Clinical picture: A 27–year-old man fulfilling DSM-Ill-R criteria for catatonic schizophrenia was treated clozapine. He later developed both and catecholamines which mimicked phaeochromocytoma. Treatment: Clozapine withdrawn. Outcome: Both blood pressure normalised. Conclusions: may induce sympathetic hyperactivity.