A5103274574- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Gut microbiota and health
- Antimicrobial agents and applications
- Diet and metabolism studies
- Respiratory Support and Mechanisms
- Extracellular vesicles in disease
- Cancer Immunotherapy and Biomarkers
- Epilepsy research and treatment
- Ferroptosis and cancer prognosis
- Poxvirus research and outbreaks
- ATP Synthase and ATPases Research
- Phagocytosis and Immune Regulation
- Inflammatory mediators and NSAID effects
- vaccines and immunoinformatics approaches
- Bacillus and Francisella bacterial research
- Pregnancy and preeclampsia studies
- Underground infrastructure and sustainability
- Machine Learning in Bioinformatics
- Liver Disease Diagnosis and Treatment
- Immune Response and Inflammation
- Childhood Cancer Survivors' Quality of Life
- Antibiotics Pharmacokinetics and Efficacy
Shandong Provincial Hospital
2023-2025
Shandong First Medical University
2023-2025
Fujian Electric Power Survey & Design Institute
2024
Institute of Microbiology
2024
Dalian Medical University
2022-2023
First Affiliated Hospital of Dalian Medical University
2022-2023
Immunogenic cell death (ICD) is a form of programmed with strong sense inflammatory detection, whose powerful situational awareness can cause the reactivation aberrant immunity. However, role ICD in pathogenesis severe acute pancreatitis (SAP) has yet to be investigated. This study aims explore pivotal genes associated SAP and how they relate immune infiltration short-chain fatty acids (SCFAs), order provide theoretical foundation for further, in-depth mechanistic studies. We downloaded...
The pivotal roles of gut microbiota in severe acute pancreatitis-associated lung injury (SAP-ALI) are increasingly revealed, and recent discoveries the gut-lung axis have provided potential approaches for treating SAP-ALI. Qingyi decoction (QYD), a traditional Chinese medicine (TCM), is commonly used clinical to treat However, underlying mechanisms remain be fully elucidated. Herein, by using caerulein plus lipopolysaccharide (LPS)-induced SAP-ALI mice model antibiotics (Abx)...
Background: Emerging evidence suggests a significant correlation between pancreatitis and gut microbiota, yet the causal relationship underlying mechanism remain largely undetermined. Given that microbiota plays crucial role in regulating circulating metabolites, we aimed to elucidate how these interactions impact risk of acute (AP).Methods: Using two-sample Mendelian randomization (MR) analysis, investigated links among plasma AP. Enrichment analysis was performed determine primary...
The pathogenesis of severe acute pancreatitis-associated lung injury (SAP-ALI), which is the leading cause mortality among hospitalized patients in intensive care unit, remains incompletely elucidated.The intestinal mucosal immune barrier a crucial component epithelial barrier, and its aberrant activation contributes to induction sustained pro-inflammatory responses, paradoxical intercellular communication, bacterial translocation.In this review, we firstly provide comprehensive overview...
Blood infection can release toxic bacterial lipopolysaccharides (LPSs) into bloodstream, trigger a series of inflammatory reactions, and eventually lead to multiple organ dysfunction, irreversible shock, even death, which seriously threatens human life health. Herein, functional block copolymer with excellent hemocompatibility is proposed enable broad-spectrum clearance LPSs from whole blood blindly before pathogen identification, facilitating timely rescue sepsis. A dipeptide ligand...
Under the background of new round power market reform, transmission and transformation construction projects are faced with many influencing factors. Therefore, article firstly uses Delphi method to sort out factors by built under Design Build(DB) mode, categorize various into four dimensions; then analyses interaction mechanism between constructing an interpretative structural model project construction, builds a hierarchical structure diagram Based on this diagram, origin process can be...
<title>Abstract</title> The recent worldwide outbreaks of mpox (monkeypox) prioritize the development a safe and effective mRNA vaccine. contemporary virus (MPXV) showed changing virological epidemiological features, notably affecting populations already vulnerable to human immunodeficiency (HIV). Herein, we profiled immunogenicity protection AR-MPXV5, novel penta-component vaccine targeting five specific proteins (M1R, E8L, A29L, A35R, B6R) from representative MPXV clade II strain, in both...
Colorectal cancer is the third most common and second leading cause of cancer-related deaths. Immune cells in tumor microenvironment play an important role development tumors. In this study, CIBERSORT was used to estimate subset immune using bulk gene expression data (i.e., TCGA, GEO, cBioPortal databases). 1,087 samples were included analysis. The results revealed that among 22 cell subsets evaluated, resting activated NK cells, macrophage M1 M2, mast are associated with significant...