A5100767038- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Cytokine Signaling Pathways and Interactions
- Ovarian function and disorders
- Autoimmune and Inflammatory Disorders Research
- Monoclonal and Polyclonal Antibodies Research
- Chronic Lymphocytic Leukemia Research
- Spondyloarthritis Studies and Treatments
- Stress Responses and Cortisol
- Reproductive Biology and Fertility
- Inflammatory mediators and NSAID effects
- Systemic Sclerosis and Related Diseases
- Renal Diseases and Glomerulopathies
- Reproductive System and Pregnancy
- Hepatitis C virus research
- Acute Lymphoblastic Leukemia research
- Acupuncture Treatment Research Studies
- Tryptophan and brain disorders
- NF-κB Signaling Pathways
- Cancer-related molecular mechanisms research
- Diet and metabolism studies
- IgG4-Related and Inflammatory Diseases
- Gout, Hyperuricemia, Uric Acid
- Pregnancy and Medication Impact
- Gut microbiota and health
The Seventh Affiliated Hospital of Sun Yat-sen University
2018-2025
Sun Yat-sen University
2014-2025
Beijing University of Chinese Medicine
2016-2025
Third Xiangya Hospital
2025
Central South University
2007-2025
Tianjin University
2004-2024
Zhejiang Chinese Medical University
2024
Zhejiang University
2022-2024
China Medical University
2024
The First Affiliated Hospital, Sun Yat-sen University
2010-2023
Recent studies indicate that the anti-malarial agent artemisinin and its derivatives may exert an anti-inflammatory effect. In this study, we explored effect of artesunate, derivative, on tumour necrosis factor (TNF)-alpha-induced production interleukins, IL-1beta, IL-6 IL-8, in human rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS), further investigated signal mechanism by which compound modulates those cytokines' production.RA FLS obtained from patients with active RA were...
Fibroblast-like synoviocytes (FLSs) are critical to synovial aggression and joint destruction in rheumatoid arthritis (RA). The role of long noncoding RNAs (lncRNAs) RA is largely unknown. Here, we identified a lncRNA, LERFS (lowly expressed fibroblast-like synoviocytes), that negatively regulates the migration, invasion, proliferation FLSs through interaction with heterogeneous nuclear ribonucleoprotein Q (hnRNP Q). Under healthy conditions, by binding mRNA RhoA, Rac1, CDC42 - small GTPase...
Abnormal glycolytic metabolism contributes to joint inflammation in rheumatoid arthritis (RA). The aims of this study were investigate the role 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), a bifunctional enzyme that controls rate, regulating fibroblast-like synoviocyte (FLS)-mediated synovial and invasiveness RA.A specific inhibitor PFKFB3, PFK15, siRNA used evaluate PFKFB3. Protein expression was measured by Western blotting or immunofluorescence staining. cytokines...
We propose a convolutional neural network (CNN) denoising based method for seismic data interpolation. It provides simple and efficient way to break though the lack problem of geophysical training labels that are often required by deep learning methods. The new consists two steps: (1) Train set CNN denoisers from natural image clean-noisy pairs learn denoising; (2) Integrate trained into project onto convex (POCS) framework perform alleviates demanding big with similar features as...
Abstract Background Microdeletion of the human chromosomal region 16p11.2 (16p11.2 $${}^{+/-}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msup> <mml:mrow/> <mml:mrow> <mml:mo>+</mml:mo> <mml:mo>/</mml:mo> <mml:mo>-</mml:mo> </mml:mrow> </mml:msup> </mml:math> ) is a prevalent genetic factor associated with autism spectrum disorder (ASD) and other neurodevelopmental disorders. However its pathogenic mechanism remains unclear, effective treatments for syndrome are lacking....
Abstract Objective There is increasing evidence that the RhoA signaling pathway may play a critical role in inflammatory response. This study was undertaken to examine effects of and its downstream effector Rho kinase (ROK) synovial inflammation rheumatoid arthritis (RA). Methods activity assessed by pull‐down assay. Fasudil Y27632, both specific inhibitors ROK, were used ROK responses vivo vitro. Nuclear translocation NF‐κB measured confocal fluorescence microscopy, DNA binding with...
Abstract Introduction Adipose derived mesenchymal stem cells (ADMSCs), carrying the similar characteristics to bone marrow cells, only much more abundant and easier obtain, may be a promising treatment for liver fibrosis. We aim investigate therapeutic potential of ADMSCs transplantation in fibrosis caused by carbon tetrachloride (CCl 4 ) rats as well its underlying mechanism, further explore appropriate infusion pathway. Methods were isolated, cultured identified. Placebo transplanted via...
Objective. To explore the roles of bromodomain (Brd) and extra-terminal domain (BET) chromatin adaptors in regulating synovial inflammation RA.
Moringa oleifera leaf (MLP) contains abundant complex nutrients with anti-osteoporosis potential. However, its efficacy and mechanisms against osteoporosis remain unknown. The purpose of this research is to investigate MLP's anti-osteoporotic effects mechanisms. Animal experiments were used in work validate efficacy. We investigated the mode action MLP, analyzed impact on gut microbiota, predicted validated anti-osteoporosis-related molecular targets pathways through network pharmacology,...
The aggressive phenotype displayed by fibroblast-like synoviocytes (FLSs) is a critical factor of cartilage destruction in rheumatoid arthritis (RA). Increased FLSs migration and subsequent degradation the extracellular matrix are essential to pathology RA. Protein inhibitor activated STAT (PIAS), whose family members include PIAS1, PIAS2 (PIASx), PIAS3, PIAS4 (PIASy), play important roles regulating various cellular events, such as cell survival, migration, signal transduction many types....
There is increasing evidence indicating that bromodomain and extra-terminal domain (BET) proteins play a critical role in the regulation of immune inflammatory responses; however, their contribution to vascular inflammation has not yet been elucidated. In this study, we investigated effect inhibiting BET on underlying mechanisms.HUVECs were isolated from fresh umbilical cords. JQ1, specific inhibitor, Brd shRNA used evaluate inflammation. Leukocyte adhesion HUVECs was measure by an assay....
Abstract Piperlongumine (PLM) is a natural product from the plant Piper longum that inhibits platelet aggregation, atherosclerosis plaque formation, and tumor cell growth. It has potential value in immunomodulation management of autoimmune diseases. In this study, we investigated role PLM regulating differentiation maturation dendritic cells (DCs), critical regulator immune tolerance, evaluated its clinical effects rheumatoid arthritis mouse model. We found treatment reduced LPS-induced...
To investigate the spectrum, antibiotic-resistant pattern, risk factors, and outcomes of infection in patients hospitalized with systemic lupus erythematosus (SLE).We collected clinical microbiological data from SLE between June 2005 2015, then conducted retrospective analyses.Among our sample 3815 patients, 1321 (34.6%) were diagnosed infection. The majority (78.3%) occurred within 5 years onset. Bacterial was predominant (50.6%), followed by viral (36.4%) fungal (12.5%). lungs (33.7%)...
Abstract The tyrosine kinase receptor vascular endothelial growth factor 2 (VEGFR2) is a critical modulator of angiogenesis. Increasing evidence indicate the important role bromodomain and extra-terminal domain (BET) chromatin adaptors in regulating tumor inflammatory response. However, whether BET proteins have angiogenesis permeability unclear. In this study, we observed that treatment with JQ1, specific inhibitor, suppressed vitro tube formation human umbilical vein cells (HUVECs) vivo...
AimsThe main objective of this study was to analyze the changes intestinal microflora and how bile acid metabolic pathways affect lipid metabolism in T2DM through gut-liver axis.MethodsFirstly, 16S rRNA sequencing, metabolomics transcriptomic sequencing were performed on plasma feces clinical subjects determine flora its metabolites. Finally, mice model verified vivo.ResultsT2DM patients have significant disorders. The differential fecal metabolites mainly enriched primary biosynthesis...
Aims Cyclophosphamide (CTX) is an established treatment of severe systemic lupus erythematosus (SLE). Cytotoxic CTX metabolites are mainly detoxified by multiple glutathione S‐transferases (GSTs). However, data lacking on the relationship between short‐term side‐effects therapy and GST genotypes. In present study, effects common GSTM1 , GSTT1, GSTP1 genetic mutations severity myelosuppression, gastrointestinal (GI) toxicity, infection incidences induced pulsed were evaluated in patients SLE....
Acute pancreatitis (AP) is a rare but life-threatening complication of SLE. The current study evaluated the clinical characteristics and risk factors for mortality patients with SLE-related AP in cohort South China. Methods . Inpatient medical records were retrospectively reviewed. Results 27 out 4053 SLE diagnosed as AP, an overall prevalence 0.67%, annual incidence 0.56‰ 37.04%. presented higher SLEDAI score (<mml:math...
This study aims to investigate the fetal outcomes and associated factors of adverse pregnancy (APOs) in pregnant women with systemic lupus erythematosus (SLE). Clinical data from 251 SLE patients 263 pregnancies 2001 2015 were analyzed retrospectively. APOs occurred 70.0% pregnancies, which loss 28.5%; preterm delivery 21.3%; intrauterine growth retardation 12.2%; distress 8.0%. Over time, rate decreased 82.8% during 2001~2005 59.6% 2011~2015. In multivariate analysis, predictors included...