About
Contact & Profiles
A5065631427
Research Areas
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
Agency for Science, Technology and Research
2022
Institute of Molecular and Cell Biology
2022
In recent decades, chimeric antigen receptor (CAR)-engineered immune effector cells have demonstrated promising antileukemic activity. Nevertheless, their efficacy remains unsatisfactory on solid cancers, plausibly due to the influence of tumor microenvironments (TME). a novel mouse cancer model with humanized system, tumor-infiltrating immunosuppressive leukocytes and exhausted programmed death protein-1 (PD-1)high T were found, which better mimic patient TME, allowing screening assessment...
10.1126/sciadv.add1187
article
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cc-by-nc
Science Advances
2022-11-23
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