A5102718328- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Tryptophan and brain disorders
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Reproductive System and Pregnancy
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA Research and Splicing
- Virus-based gene therapy research
- Cancer-related gene regulation
- Immunotherapy and Immune Responses
- Peptidase Inhibition and Analysis
- Kruppel-like factors research
- Connective Tissue Growth Factor Research
- interferon and immune responses
- RNA regulation and disease
- Plant and Fungal Interactions Research
- Catalysts for Methane Reforming
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Cells and Metastasis
- CRISPR and Genetic Engineering
- NF-κB Signaling Pathways
State Key Laboratory of Pollution Control and Resource Reuse
2024
Nanjing University
2024
Wenzhou Medical University
2022-2024
Union Hospital
2024
Jilin University
2013-2024
Qingdao Agricultural University
2023
First Affiliated Hospital of Wenzhou Medical University
2022
Southern University of Science and Technology
2020-2021
The First Affiliated Hospital, Sun Yat-sen University
2014-2020
Sun Yat-sen University
2009-2020
Emissions of volatile organic compounds (VOCs) threaten both the environment and human health. To realize elimination VOCs, Ru/CeO
Circular RNA (circRNA) is a new class of non-coding that plays pivotal role in carcinogenesis. Recently, circ-MTO1 (hsa_circ_0007874) was shown to be cancer-related circRNA. However, its lung adenocarcinoma (LUAD) has not been reported. Here, we found significantly down-regulated LUAD, which closely associated with malignant features and dismal prognosis. Enforced expression suppressed the growth LUAD cells both vitro vivo. Subsequent mechanism experiments showed served as sponge oncogenic...
BackgroundDysregulation of polycomb chromobox (CBX) proteins that mediate epigenetic gene silencing contributes to the progression human cancers. Yet their roles in clear cell renal carcinoma (ccRCC) remain be explored.MethodsThe expression CBX4 and its clinical significance were determined by qRT-PCR, western blot, immunohistochemistry statistical analyses. The biological function ccRCC tumor growth metastasis underlying mechanism investigated using vitro vivo models.FindingsCBX4 exerts...
Alzheimer's disease (AD) is the most common neurodegenerative with limited therapeutic strategies. Cell cycle checkpoint protein kinase 1 (Chk1) a Ser/Thr which activated in response to DNA damage, latter an early event AD. However, whether damage-induced Chk1 activation participates development of AD and inhibition ameliorates AD-like pathogenesis remain unclarified. Here, we demonstrate that activity levels phosphatase 2A (PP2A) inhibitory CIP2A are elevated human brains, APP/PS1...
CD36 plays a critical role in lipid metabolism, which is closely associated with human immunity.However, the of cancer remains unclear.We performed pan-cancer analysis to elucidate potential by investigating its prognostic value and current predictors for efficacy immune checkpoint inhibitors (ICIs) multiple types.CD36 expression cell lines, tumor tissue, their adjacent normal tissues displayed heterogeneity among different cancers.Immunohistochemistry was used detect confirmed results.CD36...
Ulcerative colitis (UC) is a chronic and recurrent inflammatory disease of the gastrointestinal tract. This study aimed to determine effect cathelicidin-related antimicrobial peptide (Cramp) on dextran sulfate sodium (DSS)-induced acute experimental in mice investigate underlying mechanisms. Acute UC was induced C57BL/6 with 3% DSS for 7 days, 4 mg/kg b.w. synthetic Cramp administrated once daily starting day period. Mice were evaluated body weight, colon length, histopathology, cytokines...
Gastric cancer is one of the most common malignancies in world. A number miRNAs are aberrantly expressed during progression gastric cancer. In this study, we aimed to investigate role miR-203 invasion and metastasis potential mechanism effect on tumor Our results showed that was significantly downregulated tissues cells, while ataxia telangiectasia mutated kinase (ATM) upregulated cells directly regulated by miR-203. Ectopic overexpression inhibited colony formation, migration, cells....
Abstract COP1 and COP9 signalosome (CSN) are the substrate receptor deneddylase of CRL4 E3 ligase, respectively. How they functionally interact remains unclear. Here, we uncover COP1–CSN antagonism during glucose-induced insulin secretion. Heterozygous Csn2 WT/K70E mice with partially disrupted binding IP 6 , a CSN cofactor, display congenital hyperinsulinism resistance. This is due to increased Cul4 neddylation, assembly, ubiquitylation ETV5, an obesity-associated transcriptional suppressor...
Subunit 6 of the COP9 signalosome complex, CSN6, is known to be critical regulation MDM2-p53 axis for cell proliferation and anti-apoptosis, but its many targets remain unclear. Here we show that p57 (Kip2) a target CSN6 negative regulator . associates with , overexpression can decrease steady-state expression ; accordingly, deficiency leads stabilization. Mechanistic studies Skp2, component E3 ligase, which, in turn, facilitates Skp2-mediated protein ubiquitination Loss Skp2 compromised...
MicroRNAs (miRNAs) play important roles in transcriptional regulation by targeting the 3'-UTR of target genes which participate various biological processes. We aimed to investigate potential role miR-28-5p process ovarian cancer development through regulating N4BP1. found that mRNA expression level was significantly increased tissues comparison with adjacent qRT-PCR (P<0.0001). established miR‑28‑5p promoted progression cell proliferation using colony forming assay and MTT assay. Wound...
Cancerous Inhibitor of PP2A (CIP2A), an endogenous inhibitor, is upregulated and causes reactive astrogliosis, synaptic degeneration, cognitive deficits in Alzheimer's disease (AD). However, the mechanism underlying increased CIP2A expression AD brains remains unclear. We here demonstrated that DNA damage-related Checkpoint kinase 1 (ChK1) activated human 3xTg-AD mice. ChK1-mediated overexpression drives inhibition activates STAT3, then leads to astrogliosis neurodegeneration vitro....
Schefflera octophylla (Lour.) Harms, a kind of Traditional Chinses Medicine , is commonly used in anti-inflammatory, analgesic, anti-viral, anti-tumor and hemostasis. This study aimed to determine the anti-hepatoma components its mechanism from leaves S. octophylla. The spectrum-effect relationships were analyzed by method Partial least squares, indicating that P1, P2 P10 positively correlated inhibitory activity Huh7 cells. Whereas others negatively correlated. technologies component...