A5026103467- Acute Lymphoblastic Leukemia research
- melanin and skin pigmentation
- Childhood Cancer Survivors' Quality of Life
- Acute Myeloid Leukemia Research
- Reproductive System and Pregnancy
- Advanced Battery Materials and Technologies
- Advancements in Battery Materials
- Kruppel-like factors research
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Luminescence and Fluorescent Materials
- Molecular Sensors and Ion Detection
- Endometriosis Research and Treatment
- Peroxisome Proliferator-Activated Receptors
- IL-33, ST2, and ILC Pathways
- Tryptophan and brain disorders
- Advanced biosensing and bioanalysis techniques
- Nail Diseases and Treatments
- COVID-19 and Mental Health
- Histone Deacetylase Inhibitors Research
- Advanced Battery Technologies Research
- Hematopoietic Stem Cell Transplantation
- Analytical Chemistry and Sensors
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
Shanghai Children's Medical Center
2012-2025
Shanghai Jiao Tong University
2019-2025
Obstetrics and Gynecology Hospital of Fudan University
2018-2025
Affiliated Hospital of Guizhou Medical University
2023-2024
Guizhou University
2023-2024
Huazhong University of Science and Technology
2018-2024
Third People's Hospital of Hangzhou
2018-2024
First Affiliated Hospital of Zhengzhou University
2024
Lanzhou University of Technology
2023-2024
Shenzhen Second People's Hospital
2024
TFEB suppresses oxidative stress and inflammation in endothelial cells to decrease atherosclerosis.
Abstract New preparation methods of vectors are the key to developing next generation biomacromolecule delivery systems. In this study, a controllable disulfide exchange polymerization was established obtain low‐toxicity and efficient bioreducible polyguanidines (mPEG 225 ‐ b ‐PSS n , =13, 26, 39, 75, 105) by regulating concentration activated nucleophiles reaction time under mild conditions. The relationship between degrees biocompatibility studied identify optimal polyguanidine mPEG 26 ....
Targeting at enhancing reverse cholesterol transport (RCT) is apromising strategy for treating atherosclerosis via infusion of reconstitute high density lipoprotein (HDL) as acceptors or increase efflux by activation macrophage liver X receptors (LXRs). However, systemic LXRs triggers excessive lipogenesis in the and HDL downregulates from macrophages. Here we describe an enlightened using phospholipid reconstituted apoA-I peptide (22A)-derived synthetic (sHDL) to deliver LXR agonists...
Interleukin (IL)-33, a newly described member of the IL-1 family, has been reported to facilitate primary tumor progression and metastatic dissemination. However, its biological function on decidual stromal cells (DSCs) remains unclear. In this study, we tested hypothesis whether IL-33 promotes proliferation invasion DSCs, possible mechanism. orphan receptor ST2 was found be co-expressed by DSCs in human first-trimester pregnancy. Addition IL-33, enhanced dosage-dependent manner,...
This study focusses on the anti-inflammatory and immune-modulatory roles of berberine (BBR) in ulcerative colitis (UC) treatment. Additionally, underlying mechanisms BBR were systematically explored.A 3% (w/v) dextran sodium sulphate (DSS) solution was used for establishing mice UC model. M2 macrophage polarisation induced RAW 264.7 cells using interleukin 4 (IL-4), whereas M1 lipopolysaccharide. Colon length, colon mucosa damage index (CMDI), haematoxylin-eosin (HE) staining to evaluate by...
Abstract Background and Aims Patients with acute myeloid leukaemia (AML) suffer from severe myocardial injury during daunorubicin (DNR)-based chemotherapy are at high risk of cardiac mortality. The crosstalk between tumour cells cardiomyocytes might play an important role in chemotherapy-related cardiotoxicity, but this has yet to be demonstrated. This study aimed identify its underlying mechanism explore potential therapeutic targets. Methods Cardiac tissues were harvested AML patient after...
A new cationic dansyl derivative-based (DIlSD) fluorescence probe was designed and synthesized. Its combination with anionic surfactant SDS assemblies shows enhanced intensity blue-shifted maximum wavelength. can be slightly quenched by Cu2+; however, the quenching efficiency Cu2+ is highly increased upon titration of arginine (Arg). As a result, ternary system containing fluorophore, surfactant, functions as sensitive selective sensor to Arg. The optimized displays detection limit 170 nM,...
Novel strategies of developing fluorescent sensors for proteins are highly demanded. In this work, we particularly synthesized a cholesterol-derivatized pyrene probe. Its fluorescence emission is effectively tuned by the aggregation state cationic surfactant dodecyltrimethylammonium bromide (DTAB). The used probe/DTAB assemblies exhibit sensitive ratiometric responses to pepsin and ovalbumin egg (o-egg) with detection limits 4.8 18.9 nM, respectively. changes indicate protein–surfactant...
Abstract Studies have revealed key genomic aberrations in pediatric acute myeloid leukemia (AML) based on Western populations. It is unknown to what extent the current findings represent populations with different ethnic backgrounds. Here we present landscape of driver alterations Chinese AML and discover previously undescribed aberrations, including XPO1 - TNRC18 fusion. Comprehensively comparing between cohorts reveal a substantially distinct alteration profile. For example, patients more...
Alzheimer's disease (AD) is the most common neurodegenerative with limited therapeutic strategies. Cell cycle checkpoint protein kinase 1 (Chk1) a Ser/Thr which activated in response to DNA damage, latter an early event AD. However, whether damage-induced Chk1 activation participates development of AD and inhibition ameliorates AD-like pathogenesis remain unclarified. Here, we demonstrate that activity levels phosphatase 2A (PP2A) inhibitory CIP2A are elevated human brains, APP/PS1...
Acute myeloid leukaemia (AML) is a highly heterogeneous disease, exhibiting diverse subtypes according to the characteristics of tumour cells. The immunophenotype one aspects acquired routinely through flow cytometry in diagnosis AML. Here, we characterized antigen expression paediatric AML cases across both morphological and molecular genetic subgroups. We discovered subgroup patients with unfavourable prognosis that can be immunologically characterized, irrespective FAB results or...
ABSTRACT Background Survivors of childhood cancer (CCS) and hematopoietic stem cell transplantation (HSCT) recipients are at increased risk human papillomavirus (HPV)‐associated malignancies. Although HPV vaccination is recommended for these groups, parental acceptance remains uncertain. Procedure We recruited caregivers female CCS/HSCT aged ≥9 years from the Shanghai Children's Medical Center (SCMC) clinic. Caregivers females who were least 6 months post treatment, off immunosuppressants,...
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A dansyl-functionalized fluorescent film sensor was specially designed and prepared by assembling dansyl on a glass plate surface via long flexible spacer containing oligo(oxyethylene) amine units. The chemical attachment of moieties the verified contact angle, XPS, fluorescence measurements. Solvent effect examination revealed that polarity-sensitivity retained for surface-confined moieties. Fluorescence quenching studies in water declared SAM possesses higher sensitivity towards Hg(2+)...
Surfactant aggregates modulating the cross-reactive responses of bispyrene fluorophore containing hydrophilic spacer for pattern recognition multiple heavy metal ions.
It is well established that embryonic chromosomal abnormalities (both in the number of chromosomes and structure) account for 50% early pregnancy losses. However, little known regarding potential differences incidence distribution between patients with sporadic abortion (SA) recurrent loss (RPL), let alone role submicroscopic copy-number variations (CNVs) these cases. The aim present study was to systematically evaluate CNVs etiology RPL compared SA. Over a 3-year period, 1556 fresh products...
Abstract To determine the levels and sources of chemokines in serum epidermis vitiligo patients, we examined 80 active stable patients 40 healthy controls. First, candidate were measured by Luminex assay, CCR 5, CXCR 1 3 peripheral mononuclear cells ( PMBC ) flow cytometry. Then, local elevated tested Luminex. Finally, mRNA protein expression HaCaT stimulated with interferon IFN )‐γ or tumor necrosis factor TNF )‐α quantitative real‐time polymerase chain reaction The CCL CXCL 8 10...