A5055991644- Acute Lymphoblastic Leukemia research
- Neuroblastoma Research and Treatments
- Childhood Cancer Survivors' Quality of Life
- Hematopoietic Stem Cell Transplantation
- Cancer, Hypoxia, and Metabolism
- Urological Disorders and Treatments
- Epigenetics and DNA Methylation
- Renal and related cancers
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Immune cells in cancer
Shanghai Children's Medical Center
2024-2025
Shanghai Jiao Tong University
2024-2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2018-2020
Wenzhou Medical University
2018-2020
Not available.
Summary This study delivers a comprehensive evaluation of the efficacy and pharmacokinetics high‐dose methotrexate (HDMTX) in large cohort Chinese paediatric acute lymphoblastic leukaemia patients. A total 533 patients were included prognostic analysis. An association was observed between lower steady‐state MTX concentrations (<56 μmol/L) poorer outcomes intermediate‐/high‐risk (IR/HR) Subgroup analysis further revealed that this relationship prognosis even more pronounced with MLL...
Introduction: Neuroblastoma is an embryonal tumor of the sympathetic nervous system. The MYCN oncogene amplified in some neuroblastoma patients and correlated with poor prognosis. However, less known regarding relationship between gene single-nucleotide polymorphisms (SNPs) risk. Patients methods: To investigate contribution to risk, we performed a 3-center case–control study by genotyping 4 SNPs from 429 cases 884 controls. Results: results showed that only rs57961569 G>A was associated...
Abstract Wilms tumor is the most common pediatric malignancy in kidney. The miR34b/c a downstream target gene of transcription factor p53. important role TP53 mutations, methylation miR34b/c, and interaction between these two molecules tumorigenesis have been well documented. Due to biological connection p53 present study, we investigated association polymorphisms susceptibility through genotyping functional (miR34b/c rs4938723 T&gt;C rs1042522 C&gt;G) 183 cases 603 controls....