A5100429711- Neuroblastoma Research and Treatments
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Renal and related cancers
- DNA Repair Mechanisms
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Glioma Diagnosis and Treatment
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Virus-based gene therapy research
- RNA Research and Splicing
- Lung Cancer Research Studies
- Cancer therapeutics and mechanisms
- Genetic factors in colorectal cancer
- Cell death mechanisms and regulation
- Mitochondrial Function and Pathology
- Phagocytosis and Immune Regulation
- Advanced biosensing and bioanalysis techniques
- Cancer Mechanisms and Therapy
- Bioactive Compounds and Antitumor Agents
- RNA Interference and Gene Delivery
- Ubiquitin and proteasome pathways
- Cancer Research and Treatments
Guangzhou Medical University
2018-2025
Peking University
2021-2025
Ningxia Medical University General Hospital
2024
Ningxia Medical University
2024
Jinan University
2015-2023
South China University of Technology
2021-2023
Chinese University of Hong Kong
2016-2022
University of Technology
2022
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2022
Wenzhou Medical University
2022
Abstract Background Skeletal muscle atrophy induced by either aging (sarcopenia) or mechanical unloading is associated with serious health consequences. Long non‐coding RNAs (lncRNAs) are implicated as important regulators in numerous physiological and pathological processes. Methods Microarray analysis was performed to identify the differentially expressed lncRNAs skeletal between adult aged mice. The most decreased lncRNA identified. C2C12 mouse myoblast cells were used assess biological...
Abstract Sclerostin negatively regulates bone formation by antagonizing Wnt signalling. An antibody targeting sclerostin for the treatment of postmenopausal osteoporosis was approved U.S. Food and Drug Administration, with a boxed warning cardiovascular risk. Here we demonstrate that participates in protecting system inhibiting via different loops. Loop3 deficiency genetic truncation could maintain sclerostin’s protective effect on while attenuating its inhibitory formation. We identify an...
Several virtual screening models are proposed to screen small molecules only targeting primary miRNAs without selectivity. Few attempts have been made develop strategies for discovering mature miRNAs. Mature and their specific target mRNA can form unique functional loops during argonaute (AGO)-mediated miRNA-mRNA interactions, which may serve as potential targets small-molecule drug discovery. Thus, a loop-based AGO-incorporated model is constructed the loops. The previously published...
Abstract While searching for natural anti-hepatocellular carcinoma (HCC) components in Ailanthus altissima , we discovered that ailanthone had potent antineoplastic activity against HCC. However, the molecular mechanisms underlying antitumor effect of on HCC have not been examined. In this study, and were evaluated vitro vivo . Mechanistic studies showed induced G 0 /G 1 -phase cell cycle arrest, as indicated by decreased expression cyclins CDKs increased p21 p27. Our results demonstrated...
Rationale: Sclerostin inhibition demonstrated bone anabolic potential in osteogenesis imperfecta (OI) mice, whereas humanized therapeutic sclerostin antibody romosozumab for postmenopausal osteoporosis imposed clinically severe cardiac ischemic events. Therefore, it is desirable to develop the next generation inhibitors promote formation without increasing cardiovascular risk OI. Methods and Results: Our data showed that suppressed inflammatory responses, prevented aortic aneurysm (AA)...
AlkB homolog 5 (ALKBH5) has been proven to be closely related tumors. However, the role and molecular mechanism of ALKBH5 in neuroblastomas have rarely reported.The potential functional single-nucleotide polymorphisms (SNPs) were identified by National Center for Biotechnology Information (NCBI) dbSNP screening SNPinfo software. TaqMan probes used genotyping. A multiple logistic regression model was evaluate effects different SNP loci on risk neuroblastoma. The expression neuroblastoma...
The recurrence and metastasis of children with mediastinal neuroblastoma (NB) are also occurred after surgery, chemotherapy, or radiotherapy. Strategies targeting the tumor microenvironment have been reported to improve survival; however, thorough investigations monocytes tumor-associated macrophages (Mϕs) specialized functions in NB still lacking. Our data first demonstrated polypyrimidine tract binding protein 2 (PTBP2) as a possible identifier patients screened by proteomic profiling that...
Abstract Background Heterogeneous clinical features and prognosis in neuroblastoma (NB) children are frequently dominated by immune elements. Dysfunction apoptosis cells result from the exposure to continuous tumor-related antigen stimulation coinhibitory signals. To date, key factors pointing restriction of NB-specific CD8 + T remain elusive. Methods We performed bulk-RNA sequencing lipidomic analyses with mediastinal NB. Bioinformatics analysis biological validation were applied uncover...
Variations in nucleotide excision repair pathway genes may predispose to initiation of cancers. However, polymorphisms ERCC1/XPF and neuroblastoma risk have not been investigated before. To evaluate the relevance influencing susceptibility, we genotyped four using a Chinese population 393 cases 812 controls. The results showed that ERCC1 rs2298881 rs11615 predisposed enhanced [CA vs. AA: adjusted odds ratio (OR) = 1.94, 95% confidence interval (CI) 1.30–2.89, P 0.0012; CC OR 2.18, CI...
Neuroblastoma is the primary cause of cancer death in childhood. METTL14 tightly linked to cancer. However, whether single-nucleotide polymorphisms (SNPs) gene could predispose neuroblastoma susceptibility lacks evidence. With an epidemiology case-control study, associations between SNPs and overall risk for were estimated 898 cases 1,734 controls. Following that, stratified analysis was performed. Among five analyzed SNPs, rs298982 G>A rs62328061 A>G exhibited a significant association with...
Epithelial-mesenchymal transition (EMT) plays an important role in prostate cancer (PCa) metastasis; thus, developing EMT inhibitors may be a feasible treatment for metastatic PCa. Here, we discovered that arenobufagin and four other bufadienolides suppressed PC3 cell EMT. These compounds modulated marker expression with elevating E-cadherin reducing ZEB1, vimentin slug expression, attenuated the migration invasion of cells. Among these five compounds, exhibited most potent activity. We...
Reversing established muscle atrophy following mechanical unloading is of great clinical challenge. Long noncoding RNAs (lncRNAs) have been demonstrated to play important roles in myogenesis. Here we identified a lncRNA (mechanical unloading-induced atrophy-related [lncMUMA]) enriched muscle, which was the most downregulated during development hindlimb suspension (HLS) mice. The vitro and vivo data that decreased expression levels lncMUMA closely associated with reduction myogenesis...
Neuroblastoma is the third most common childhood cancer after leukemias and of central nervous system.Long noncoding RNA MEG3 polymorphisms have been shown to confer susceptibility; however, their roles in genetic predisposition neuroblastoma remain unclarified.To answer this question, we genotyped two polymorphisms, rs7158663 G>A rs4081134 G>A, 392 children 783 controls by TaqMan method.The results showed that neither single locus nor combination analysis supported an association between...
The prognostic role of adjacent nontumor tissue in hepatocellular carcinoma (HCC) patients is still not clear. activity changes immunologic and hallmark gene sets tissues may substantially impact on prognosis by affecting proliferation liver cells colonization circulating tumor after HCC treatment measures such as hepatectomy. We aimed to identify subtypes based the tissues, improve patient outcomes. comprehensively revealed samples set variation analysis (GSVA), identified three clinically...
Glioma is a highly heritable disease with strong genetic component. The N6-methyladenosine (m6A) modification core genes play important roles in the context of cancer. However, effects polymorphisms m6A on risk pediatric glioma remain undefined. Here, we intended to demonstrate relationship between 24 functional single-nucleotide (SNPs) eight and risk. Case-control design multinomial logistic regression were used develop models estimate while accounting for subtypes glioma. A total 171 cases...