A5063641621- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Acute Myeloid Leukemia Research
- Neuroblastoma Research and Treatments
- Chronic Myeloid Leukemia Treatments
- Lung Cancer Research Studies
- Adolescent and Pediatric Healthcare
- Cancer Genomics and Diagnostics
- CAR-T cell therapy research
- Hematopoietic Stem Cell Transplantation
- Chronic Lymphocytic Leukemia Research
- Neutropenia and Cancer Infections
- Renal cell carcinoma treatment
- Family Support in Illness
- Renal and related cancers
- Virus-based gene therapy research
- Neonatal Respiratory Health Research
- Immune Cell Function and Interaction
- Pleural and Pulmonary Diseases
- Multiple Myeloma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Lymphoma Diagnosis and Treatment
- DNA Repair Mechanisms
- Hepatitis B Virus Studies
- Cancer therapeutics and mechanisms
Shanghai Hospital Development Center
2025
Shanghai Jiao Tong University
2016-2025
Shanghai Children's Medical Center
2016-2025
Shihezi University
2025
All India Institute of Medical Sciences Jodhpur
2024
Science and Technology Commission of Shanghai Municipality
2011
XinHua Hospital
2007
<h3>Importance</h3> A randomized clinical trial is needed to determine whether the second-generation Abl–tyrosine kinase inhibitor dasatinib more effective than first-generation imatinib mesylate for childhood Philadelphia chromosome–positive acute lymphoblastic leukemia (ALL). <h3>Objective</h3> To given at a daily dosage of 80 mg/m<sup>2</sup>is 300 mg/m<sup>2</sup>to improve event-free survival children with ALL in context intensive chemotherapy without prophylactic cranial irradiation....
We determined the safety and efficacy of coadministration CD19- CD22-chimeric antigen receptor (CAR) T cells in patients with refractory disease or high-risk hematologic isolated extramedullary relapse B-acute lymphoblastic leukemia.
Objectives Before 2003, most children with acute lymphoblastic leukaemia (ALL) abandoned treatment, only approximately 30% treated in China. With the development of national insurance for underprivileged patients, we assessed current frequency and causes treatment abandonment among patients ALL who were enrolled Chinese Children’s Cancer Group protocol between 2015 2016. Methods Demographic, clinical laboratory data on as well economic sociocultural their families collected analysed. General...
Abstract Studies have revealed key genomic aberrations in pediatric acute myeloid leukemia (AML) based on Western populations. It is unknown to what extent the current findings represent populations with different ethnic backgrounds. Here we present landscape of driver alterations Chinese AML and discover previously undescribed aberrations, including XPO1 - TNRC18 fusion. Comprehensively comparing between cohorts reveal a substantially distinct alteration profile. For example, patients more...
ABSTRACT Background Survivors of childhood cancer (CCS) and hematopoietic stem cell transplantation (HSCT) recipients are at increased risk human papillomavirus (HPV)‐associated malignancies. Although HPV vaccination is recommended for these groups, parental acceptance remains uncertain. Procedure We recruited caregivers female CCS/HSCT aged ≥9 years from the Shanghai Children's Medical Center (SCMC) clinic. Caregivers females who were least 6 months post treatment, off immunosuppressants,...
Introduction Corticosteroids are used for toxicity management, raising concerns about whether they may affect the anti-leukemic effects of chimeric antigen receptor (CAR)-T cells. Methods and results In this study, we retrospectively analyzed patients (fined two subgroups based on disease burden. Of 75 cases in low burden (LDB) group (MRD &lt; 5%, no extramedullary disease), there was significant difference between use steroids event-free survival (EFS) ( p = 0.21) overall (OS) 0.26),...
To the Editor: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an essential treatment for various malignant hematological diseases, non-malignant immunodeficiency and metabolic diseases in children.[1] During period of post allo-HSCT before complete immune reconstitution, transplant recipients having a compromised system are more susceptible to infectious than general population. Therefore, revaccination plays crucial role protecting pediatric from vaccine-preventable...
Survivors of childhood cancer often experience treatment-related chronic health conditions. Given its vast population, China shares a large proportion the global burden. Yet, screening and treatment late effects in survivors remain underaddressed most regions China. This study aimed to identify high-priority for harmonizing guidelines within Chinese Children's Cancer Group (CCCG), as well barriers enablers implementation surveillance recommendations local practice.
Summary This study delivers a comprehensive evaluation of the efficacy and pharmacokinetics high‐dose methotrexate (HDMTX) in large cohort Chinese paediatric acute lymphoblastic leukaemia patients. A total 533 patients were included prognostic analysis. An association was observed between lower steady‐state MTX concentrations (<56 μmol/L) poorer outcomes intermediate‐/high‐risk (IR/HR) Subgroup analysis further revealed that this relationship prognosis even more pronounced with MLL...
Abstract Long‐term follow‐up data for childhood acute lymphoblastic leukemia (ALL) are scarce in China because of lacking population‐based and hospitalized registry system. This retrospective study, conducted at Shanghai's Children's Medical Center (SCMC), aimed to investigate the long‐term results ALL identify prognostic factors. The Pediatric Oncology Network Database, designed by St. Jude Research Hospital, USA, were used collect enrolled patients starting 2005. From 2005 2014, 1085...
Abstract Background Septicemia is an important cause of treatment‐related mortality and treatment failure in pediatric acute lymphoblastic leukemia (ALL) developing countries. A multicenter CCCG‐ALL‐2015 study was conducted China factors associated with septicemia were studied. Methods Patients participated from January 2015 to December 2017 included. documented identified the Data Center additional data collected. Results total 4080 patients recruited 527 (12.9%, 95% CI 11.9%‐13.9%). The...
This pilot study focused on whether flow cytometry (FCM) detection of minimal residual disease in bone marrow (BM) could predict the outcome patients with advanced neuroblastoma (NB).Fifty-seven stage 4 NB BM infiltration were enrolled this study. All them received NB-2001 protocol. samples examined for tumor cell contamination by both morphology and FCM CD45-FITC/CD81-PE/CD56-PECy5 monoclonal antibodies cocktail at diagnosis after courses chemotherapy.BM all positive FCM, from 30 became...
Abstract Tumor lysis syndrome (TLS) is a common and fatal complication of childhood hematologic malignancies, especially acute lymphoblastic leukemia (ALL). The clinical features, therapeutic regimens, outcomes TLS have not been comprehensively analyzed in Chinese children with ALL. A total 5537 ALL were recruited from the Children’s Cancer Group, including 79 diagnosed TLS. characteristics, treatment survival patients analyzed. Age distribution was remarkably different those without White...
Abstract Background Contemporary risk‐directed treatment has improved the outcome of patients with acute lymphoblastic leukemia (ALL) and TCF3::PBX1 fusion. In this study, authors seek to identify prognostic factors that can be used further improve outcome. Methods The studied 384 genotype treated on Chinese Children's Cancer Group ALL‐2015 protocol between January 1, 2015 December 31, 2019. All provisionally received intensified chemotherapy in intermediate‐risk arm without prophylactic...
For around half of the pediatric B-lineage acute lymphoblastic leukemia (B-ALL) patients, molecular mechanism relapse remains unclear. To fill this gap in knowledge, here we characterize chromatin accessibility landscape relapsed B-ALL. We observe rewired accessible regions (ACRs) associated with transcription dysregulation cells as compared normal B-cell progenitors. show that over a quarter ACRs B-ALL are quiescent high heterogeneity among B-ALLs. identify subtype-specific and...
Langerhans cell histiocytosis (LCH) is the most common with constitutive activation of RAS–RAF–MEK–ERK (MAPKinase) signaling pathway. We analyzed 89 cases BRAF and MAP2K1 mutations by Sanger sequencing, which 18 showed that these two gene are negative. Whole genome sequencing suitable specimens in negative revealed a translocation from 3 intron PLEKHA6 to 13 NTRK3 one case. identified this could cause novel fusion mutation, PLEKHA6‐NTRK3. Overexpression PLEKHA6‐NTRK3 mutant NIH 3T3 cells...