A5050733356- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Neutropenia and Cancer Infections
- Cell Adhesion Molecules Research
- Autoimmune and Inflammatory Disorders Research
- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- Parvovirus B19 Infection Studies
- Neonatal Health and Biochemistry
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Adolescent and Pediatric Healthcare
- Colorectal Cancer Surgical Treatments
- Child and Adolescent Health
- Oral health in cancer treatment
- Dermatological and COVID-19 studies
- Hearing, Cochlea, Tinnitus, Genetics
- Educational Systems and Policies
- Hedgehog Signaling Pathway Studies
- Family and Disability Support Research
- Neonatal Respiratory Health Research
- Frailty in Older Adults
Longyan University
2024-2025
Children's Hospital of Chongqing Medical University
2016-2025
Chongqing Medical University
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
Wangjing Hospital of China Academy of Chinese Medical Sciences
2025
Chinese PLA General Hospital
2022-2023
Shanghai Jiao Tong University
2023
Southwest University
2023
Sichuan University
2023
University of Chinese Academy of Sciences
2023
<h3>Importance</h3> A randomized clinical trial is needed to determine whether the second-generation Abl–tyrosine kinase inhibitor dasatinib more effective than first-generation imatinib mesylate for childhood Philadelphia chromosome–positive acute lymphoblastic leukemia (ALL). <h3>Objective</h3> To given at a daily dosage of 80 mg/m<sup>2</sup>is 300 mg/m<sup>2</sup>to improve event-free survival children with ALL in context intensive chemotherapy without prophylactic cranial irradiation....
Acute lymphoblastic leukemia (ALL) is the most common malignancy among children. The trial Chinese Children Leukemia Group (CCLG)‐ALL 2008 was a prospective clinical designed to improve treatment outcome of childhood ALL through first nation‐wide collaborative study in China. Totally 2231 patients were recruited from ten tertiary hospitals eight cities. stratified according clinical‐biological characteristics and early response. Standard risk (SR) intermediate (IR) groups treated with...
Genetic alterations play a pivotal role in leukemic clonal transformation, significantly influencing disease pathogenesis and clinical outcomes. Here, we report novel fusion gene investigate its pathogenic acute lymphoblastic leukemia (ALL). We engineer transposon transfection system expressing the TOP2B::AFF2 transcript introduce it into Ba/F3 cells. Functional studies, including proliferation, cell cycle, apoptosis assays, were conducted to assess gene's impact. In vitro assays reveal that...
ABSTRACT Objective A number of susceptibility genes in prostate tissue have been identified to be associated with cancer (PCa) risk. However, the reported based on assessing could not fully explain PCa genetic susceptibility. It is believed that functioning immune system may fill gap some missing heritability. Methods To study potential acting such pathways, we performed a transcriptome‐wide association (TWAS) 79,194 cases and 61,112 control European ancestry by using three sets gene...
This randomized controlled trial aims to evaluate the efficacy and safety of Yishenyangsui granule for treating Degenerative Cervical Myelopathy. A randomized, double-blind, placebo-controlled clinical was conducted with 152 participants recruited from three centers randomly assigned receive either or placebo. The Japanese Orthopaedic Association (JOA) score Neck Disability Index (NDI) were evaluated 32 weeks. Patient-reported outcomes including surgical treatment data, re-treatment...
<sec> <title>BACKGROUND</title> Hemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening condition predominantly affecting children, characterized by hyperinflammation high early mortality. While the HScore criteria, developed Fardet et al. in 2014, have been widely used to diagnose HLH, recent studies also explored its potential predict disease severity COVID-19 patients, with findings indicating that higher values correlate increased mortality risk may identify patients who...
Abstract Background Currently, most research on hemophagocytic lymphohistiocytosis (HLH) have focused etiology and therapy, leaving few epidemiological reports. The published studies of China are mainly regional investigations. We aimed to present the overall status HLH in China, provide Chinese data for international investigation. Methods cases 2019 were collected statistically analyzed. Findings Epstein-Barr virus accounted 44.01% 1445 31 regions was common cause. Lymphoma-associated...
Abstract Background Inflammatory, immune, and nutritional status are key factors in obstructive colorectal cancer (OCRC). This study aims to investigate the value of modified Naples prognostic score (M-NPS) evaluating OCRC prognosis. Methods A total 196 patients were retrospectively analyzed construct M-NPS based on serum albumin (ALB), cholesterol (CHOL), neutrophil:lymphocyte ratio (NLR), lymphocyte:monocyte (LMR), then they divided into three groups. The Kaplan–Meier (KM) method Cox...
Acute myeloid leukemia (AML) is a hematological malignancy that commonly occurs in children. The prognosis of pediatric AML relatively poor, thus threatening the patient's survival. aberrant expression axon guidance factor, netrin-1, observed various types malignancies, and it participates proliferation apoptosis tumor cells. Herein, we aimed to explore role netrin-1 Netrin-1 highly expressed patients. Proliferation anti-apoptosis were cells treated with netrin-1. interaction between Unc-5...
Background Tumor lysis syndrome (TLS) often occurs early after induction chemotherapy for acute lymphoblastic leukemia (ALL) and can rapidly progress. This study aimed to construct a machine learning model predict the risk of TLS using clinical indicators at time ALL diagnosis. Methods observational cohort was conducted National Clinical Research Center Child Health Disease. Data were collected from pediatric patients diagnosed between December 2008 2021. Four models constructed Least...
The prevalence and clinical relevance of KIT mutations in childhood core-binding factor (CBF) acute myeloid leukemia (AML) have not been well characterized. In this study, a total 212 children with de novo AML were enrolled from Chinese population 50 (23.5%) the patients deemed CBF-AML. identified 30% CBF-AML cohort. clustered exon 17 8, exons 8 correlated shorter overall survival (OS) (5-year OS: 30.0 ± 14.5% vs. 73.0 8.5%, p = .007) event-free (EFS) EFS: .003). Multivariate analysis...
The cytokine receptor-like factor 2 (CRLF2) gene plays an important role in early B-cell development. Aberrations CRLF2 activate the JAK-STAT signaling pathway that contributes to acute lymphoblastic leukemia (B-ALL). prognostic significance of overexpression and P2RY8-CRLF2 fusion various B-ALL risk subgroups has not been well established. Two hundred seventy-one patients with newly diagnosed childhood were enrolled from a Chinese population. prevalence overexpression, CRLF2-P2RY8 fusion,...
Abstract Background Septicemia is an important cause of treatment‐related mortality and treatment failure in pediatric acute lymphoblastic leukemia (ALL) developing countries. A multicenter CCCG‐ALL‐2015 study was conducted China factors associated with septicemia were studied. Methods Patients participated from January 2015 to December 2017 included. documented identified the Data Center additional data collected. Results total 4080 patients recruited 527 (12.9%, 95% CI 11.9%‐13.9%). The...
To cite this article: Zhang Z‐Y, Zhao X‐D, Jiang L‐P, Liu E‐M, Cui Y‐X, Wang M, Wei H, Yu J, An Y‐F, Yang X‐Q. Clinical characteristics and molecular analysis of three Chinese children with Omenn syndrome. Pediatr Allergy Immunol 2011; 22 : 482–487. Abstract syndrome (OS) is a rare autosomal recessive genetic disorder presents symptoms severe combined immunodeficiency characterized by erythrodermia, eosinophilia, hepatosplenomegaly, lymphadenopathy, elevated serum IgE levels. OS has been...
Abstract Background Contemporary risk‐directed treatment has improved the outcome of patients with acute lymphoblastic leukemia (ALL) and TCF3::PBX1 fusion. In this study, authors seek to identify prognostic factors that can be used further improve outcome. Methods The studied 384 genotype treated on Chinese Children's Cancer Group ALL‐2015 protocol between January 1, 2015 December 31, 2019. All provisionally received intensified chemotherapy in intermediate‐risk arm without prophylactic...
Congenital agammaglobulinemia is a humoral primary immunodeficiency and affected patients have extremely low levels of peripheral B cells profound deficiency all immunoglobulin isotypes. Mutations the Bruton's tyrosine kinase (BTK) gene are responsible for most congenital agammaglobulinemia. In this study, phenotypes were investigated in 21 male children from unrelated Chinese families. Sixteen different mutations BTK identified 18 patients, three did not mutations. Nine had been reported...
Zhang Z‐Y, Xiao H‐Q, Jiang L‐P, Zhou Y, Zhao Q, Yu J, Liu W, Yang X‐Q, X‐D. Analysis of clinical and molecular characteristics Wiskott–Aldrich syndrome in 24 patients from 23 unrelated Chinese families. Pediatr Allergy Immunol 2010: 21: 522–532. © 2010 John Wiley & Sons A/S The data children with (WAS) families were reviewed the present study. WAS protein (WASP) expression peripheral blood mononuclear cells was examined by flow cytometry (FCM); WASP gene amplified PCR directly sequenced...
Acute myeloid leukemia (AML) is relatively rare in children. Somatic mutations including the single nucleotide polymorphism (SNP) rs16754 Wilms tumor 1 gene (WT1) and their prognostic relevance pediatric AML have not been studied Chinese populations. We analyzed WT1 genotypes a cohort of 86 patients with de novo population. detected approximately 20% patients. Most identified were deletions insertions clustered exons 7 9. No differences observed respect to overall survival relapse-free...
The altered concentrations of amino acids were found in the bone marrow or blood leukemia patients. Metabolomics technology combining mathematical model biomarkers could be used for assisting diagnosis pediatric acute (AL). 17 was measured by targeted liquid chromatograph–tandem mass spectrometry periphery collected using dried spots. After evaluation, models further evaluated prospective clinical validation cohort AL diagnosis. 13 statistically different between serum dots LC–MS/MS....
Abstract The success of treating a wide variety pediatric diseases with HSCT , hematologic malignancies in particular, has resulted an increased number long‐term survivors. This study is the first large‐scale, multicentre report that describes evolution s C hina during period 1998–2012. Of all 1052 patients, 266 cases were treated autologous HSC and 786 used allogeneic s. disease indications for mainly included leukemias, lymphoma, solid tumors, non‐malignant disorders. total s, especially...
This multicenter retrospective study included 184 children with malignant and non-malignant diseases who underwent UCBT between January 1998 August 2012. The disease group 101 ALL, AML, CML, JMML, MDS, the 83 PID, β-thalassemia, IMD BMF, HLH. median duration to neutrophil platelet engraftment was 16 35 days in vs 15 38 group. cumulative incidence of grade II-IV aGVHD cGVHD 25.6% 13.5% 19.7% 11.1% group, respectively. engraftment, were similar two groups. Of pediatric patients, 114 patients...