A5101689117- Immune Cell Function and Interaction
- Colorectal Cancer Surgical Treatments
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Gastric Cancer Management and Outcomes
- Galectins and Cancer Biology
- Immune cells in cancer
- Colorectal Cancer Treatments and Studies
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Anorectal Disease Treatments and Outcomes
- Psoriasis: Treatment and Pathogenesis
- Signaling Pathways in Disease
- MicroRNA in disease regulation
- Esophageal and GI Pathology
- RNA modifications and cancer
- Intestinal and Peritoneal Adhesions
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Circular RNAs in diseases
- Cancer Mechanisms and Therapy
- Cardiac, Anesthesia and Surgical Outcomes
- Colorectal and Anal Carcinomas
Shanghai Jiao Tong University
2025
Renji Hospital
2025
Huazhong University of Science and Technology
2015-2024
Union Hospital
2015-2024
First Hospital of Lanzhou University
2023
Zhejiang Shuren University
2023
Lanzhou University
2023
Union Hospital
2014-2020
University of Michigan–Ann Arbor
2009-2018
Zero to Three
2012
The interaction between T cell immunoglobulin- and mucin-domain-containing molecule (Tim-3) expressed on helper 1 (Th1) cells, its ligand, galectin-9, negatively regulates Th1-mediated immune responses. However, it is poorly understood if how the Tim-3/galectin-9 signaling pathway involved in escape patients with hepatocellular carcinoma (HCC). Here we studied expression, function, regulation of hepatitis B virus (HBV)-associated HCC. We detected different levels galectin-9 expression...
Abstract B7-H1 is a recently identified B7 family member that, along with one of its receptors, programmed death-1 (PD-1), has been involved in multiple immunopathologic scenarios. However, the nature and PD-1 human hepatocellular carcinoma (HCC) remains poorly defined. We investigated expression functional relevance this pathway patients HCC. showed that on Kupffer cells (KC) was increased tumor tissues compared surrounding nontumor liver HCC correlated poorer survival. Coculture monocytes...
Abstract Foxp3+CD4+ regulatory T (Treg) cells inhibit immune responses and temper inflammation. IL-17+CD4+ (Th17) mediate inflammation of autoimmune diseases. A small population IL-17+Foxp3+CD4+ has been observed in peripheral blood healthy human beings. However, the biology remains poorly understood humans. We investigated their phenotype, cytokine profile, generation, pathological relevance patients with ulcerative colitis. that high levels were selectively accumulated colitic...
Infiltration of tumors with effector T cells is positively associated therapeutic efficacy and patient survival. However, the mechanisms underlying T-cell trafficking to tumor microenvironment remain poorly understood in patients colon cancer. The polycomb repressive complex 2 (PRC2) involved cancer progression, but regulation immunity by epigenetic has yet be investigated. In this study, we examined relationship between PRC2 machinery trafficking. We found that components demethylase...
Activated T cells may express FOXP3. It is thought that FOXP3 not a specific marker to determine regulatory (Treg) in humans. Here, we examined the functional phenotype and cytokine profile of vitro induced FOXP3(+) cells, primary FOXP3(-) patients with ulcerative colitis tumors including colon carcinoma, melanoma, hepatic ovarian pancreatic cancer, renal cell carcinoma. We observed similar levels suppressive capacity blood, tumors, colitic tissues. Compared same microenvironment, these...
Recent studies have shown that interferon-γ (IFN-γ)-induced galectin-9 expression in Kupffer cells plays an essential role modulatingthe microenvironment of hepatitis-associated hepatocellular carcinoma (HCC). However, whether or not IFN-γ induces HCC cells, its biological and regulatory mechanism development progression are poorly defined. Quantitative PCR western blotting analysis were used to detect EZH2 levels cell lines stimulated with IFN-γ. Bioinformatics luciferase reporter assay...
The involvement of T-cell immunoglobulin mucin-3 (Tim-3) in the regulation solid organ transplantation rejection is largely unknown. We used galectin-9 (Tim-3 ligand) to evaluate effect and mechanisms Tim-3/galectin-9 pathway an allogeneic heart transplant model.The murine cardiac model from BALB/c (H-2d) C57BL/6 (H-2b) was built. recipients were administered with for 7 days day 1 or 3 posttransplant. complete cessation contractility defined as observation endpoint. on cell proliferation...
The most common cause of gastric cancer is infection with helicobacter pylori (HP), but the associated molecular mechanism not well understood. In present study, we found a marked increase in expression B7-H1, member B7 co-stimulatory family molecules that bind to programmed death-1 (PD-1) and play critical immunoregulatory role cell-mediated immune response, HP-positive tissue. Infection cultured cells HP promoted B7-H1 inhibited miR-152 miR-200b expression. We further demonstrated these...
Foxp3+CD4+ regulatory T (Treg) cells are thought to express negligible levels of effector cytokines, and inhibit immune responses inflammation. Here, we have identified a population IL-8+Foxp3+CD4+ in human peripheral blood, which is selectively increased the microenvironments ulcerative colitis colon carcinoma. Phenotypically, this minimally overlapping with IL-17+Foxp3+CD4+ cells, different from IL-8−Foxp3+CD4+ same microenvironment. 40–60% exhibit naive phenotype CD127, whereas basically...
Special AT-rich sequence binding protein 1 (SATB1) is a nuclear factor that functions as global chromatin organizer to regulate gene expression. Recent studies have suggested an oncogenic role of SATB1 in breast cancer. However, the gastric cancer, especially regulating malignant phenotypes, including multidrug resistance (MDR) and metastasis, remains poorly understood. In this study, aggressive human cancer cell line SGC7901 its corresponding MDR variant SGC7901/VCR cells were used model....
Abstract Peritoneal adhesions are fibrous tissues formed after surgery. Both cytokines and transforming growth factors ( TGF s) involved in this process. The objective of study was to investigate the cross talk between these entities. drainage fluid surgery from patients rodent models examined by enzyme‐linked immunosorbent assay fluorescence‐activated cell sorter. Data showed that concentrations interferon IFN )‐γ interleukin IL )‐17 reached their peaks 6–12 hours surgery, whereas ‐β1 two...
Abstract Background Inflammatory, immune, and nutritional status are key factors in obstructive colorectal cancer (OCRC). This study aims to investigate the value of modified Naples prognostic score (M-NPS) evaluating OCRC prognosis. Methods A total 196 patients were retrospectively analyzed construct M-NPS based on serum albumin (ALB), cholesterol (CHOL), neutrophil:lymphocyte ratio (NLR), lymphocyte:monocyte (LMR), then they divided into three groups. The Kaplan–Meier (KM) method Cox...
Abstract Naive T cells are thought to be functionally quiescent. In this study, we studied and compared the phenotype, cytokine profile, potential function of human naive CD4+ in umbilical cord peripheral blood. We found that cells, but not memory expressed high levels chemokine CXCL8. CXCL8+ were preferentially enriched CD31+ did express cell activation markers or typical Th effector cytokines, including IFN-γ, IL-4, IL-17, IL-22. addition, upon activation, retained CXCL8 expression....