A5100379831- Esophageal Cancer Research and Treatment
- Coronary Interventions and Diagnostics
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Ferroelectric and Piezoelectric Materials
- Cardiac, Anesthesia and Surgical Outcomes
- Microwave Dielectric Ceramics Synthesis
- Anesthesia and Pain Management
- Diet and metabolism studies
- Hip and Femur Fractures
- Anesthesia and Sedative Agents
- Bariatric Surgery and Outcomes
- Nausea and vomiting management
- Intensive Care Unit Cognitive Disorders
- Enhanced Recovery After Surgery
- Immune cells in cancer
- Perovskite Materials and Applications
- Dielectric properties of ceramics
- Spine and Intervertebral Disc Pathology
- Effects of Radiation Exposure
- Anesthesia and Neurotoxicity Research
- Advanced ceramic materials synthesis
- DNA Repair Mechanisms
- Surgical site infection prevention
- Quantum Dots Synthesis And Properties
Peking University
2014-2024
Hubei University of Science and Technology
2019-2024
Beijing Jishuitan Hospital
2014-2024
Capital Medical University
2020-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Peking Union Medical College Hospital
2015-2024
Union Hospital
2014-2023
Huazhong University of Science and Technology
2014-2023
Shanxi Medical University
2022-2023
Shantou University
2012-2023
Purpose The efficacy of neoadjuvant chemoradiotherapy (NCRT) plus surgery for locally advanced esophageal squamous cell carcinoma (ESCC) remains controversial. In this trial, we compared the survival and safety NCRT with alone in patients ESCC. Patients Methods From June 2007 to December 2014, 451 potentially resectable thoracic ESCC, clinically staged as T1-4N1M0/T4N0M0, were randomly allocated (group CRT; n = 224) S; 227). group CRT, received vinorelbine 25 mg/m2 intravenously (IV) on days...
The prognosis of patients with locally advanced esophageal squamous cell carcinoma (ESCC) remains poor after surgery. Neoadjuvant chemoradiotherapy (NCRT) has been shown to potentially improve survival.To compare the treatment efficacy NCRT plus surgery alone for long-term survival among ESCC.The Chemoradiotherapy Esophageal Cancer 5010 study was a multicenter open-label randomized phase 3 clinical trial that enrolled between June 1, 2007, and December 31, 2014. Follow-up ended on 2019....
Background/Objective Inadvertent intraoperative hypothermia (core temperature <360 C) is a recognized risk in surgery and has adverse consequences. However, no data about this complication China are available. Our study aimed to determine the incidence of inadvertent its associated factors sample Chinese patients. Methods We conducted regional cross-sectional survey Beijing from August through December, 2013. Eight hundred thirty patients who underwent various operations under general...
Abstract Metastasis remains the primary cause of small cell lung cancer (SCLC)-related deaths. Growing evidence links tumor metastasis with a pre-metastatic microenvironment characterized by an anti-inflammatory response, immunosuppression, and presence tumor-derived exosomes. To clarify relationships among these factors in SCLC, we analyzed SCLC patient samples as well mouse model. Among infiltrating immune cells, our study focused on tumor-associated macrophages (TAMs), that are well-known...
Abstract Background Radiation-induced lung injury (RILI) is the most common and serious complication of chest radiotherapy. However, reported radioprotective agents usually lead to radiation resistance in tumor cells. The key solving this problem distinguish between response cells normal epithelial damage. Methods RNA-Seq was used recognize potential target alleviating progression RILI as well inhibiting growth. activation NLRP3 inflammasome screened by qRT-PCR, western blotting,...
Severe pain and high-dose opioids are both associated with increased risk of postoperative delirium. The authors investigated whether parecoxib-supplemented IV morphine analgesia could decrease the incidence delirium in elderly patients after total hip or knee replacement surgery.In a randomized, double-blind, 2-center trial, 60 years older who underwent elective surgery were assigned 1:1 ratio to receive either parecoxib (40 mg at end then every 12 hours for 3 days) placebo (normal saline)....
Abstract Background Malnutrition is a common geriatric syndrome and can be targeted preoperatively to decrease the risk of postoperative delirium (POD) in older adult patients. To analyze value prognostic nutritional index (PNI) predict incidence POD patients with hip fractures. Methods This was prospective, observational, cohort study Preoperative PNI calculated as 10 × serum albumin (g/dL) + 0.005 total lymphocyte count (/μL) using preoperative laboratory results. Patients were divided...
To determine the prognostic impact of pathologic lymph node (LN) status and investigate risk factors recurrence in esophageal squamous cell carcinoma (ESCC) patients with complete response (pCR) after neoadjuvant chemoradiotherapy (NCRT).There are no large-scale prospective study data regarding ypN pCR ESCC receiving NCRT.The NEOCRTEC5010 trial was a multicenter that compared survival safety NCRT plus surgery (S) S locally advanced ESCC. The relationships between cN, pN, were assessed....
SARS-CoV-2 has become a global threat to public health. Infected individuals can be asymptomatic or develop mild severe symptoms, including pneumonia, respiratory distress, and death. This wide spectrum of clinical presentations infection is believed in part due the polymorphisms key genetic factors population. In this study, we report that interferon-induced antiviral factor IFITM3 inhibits by preventing spike-protein-mediated virus entry cell-to-cell fusion. Analysis Chinese COVID-19...
To identify miRNA markers useful for esophageal squamous cell carcinoma (ESCC) neoadjuvant chemoradiotherapy (neo-CRT) response prediction.Neo-CRT followed by surgery improves ESCC patients' survival compared with alone. However, CRT outcomes are heterogeneous, and no current methods can predict responses.Differentially expressed miRNAs between pathological responders nonresponders after neo-CRT were identified profiling verified real-time quantitative polymerase chain reaction (qPCR) of 27...
To clarify whether systemic LND influences the safety of surgery and survival patients with locally advanced esophageal squamous cell carcinoma (ESCC) after neoadjuvant chemoradiotherapy (nCRT).Prognostic impact lymphadenectomy during nCRT for ESCC is still uncertain requires clarification.This a secondary analysis NEOCRTEC5010 trial which compared followed by versus alone ESCC. Relationship between number perioperative, recurrence, outcomes were analyzed in group.Three-year overall was...
Few studies have exclusively investigated the value of pathological complete response (pCR), in esophageal squamous cell carcinoma (ESCC) patients, although it is a clinically significant parameter to evaluate impact neoadjuvant chemoradiotherapy (nCRT) on treatment outcome after surgery. The aim our study was explore relationship between pCR nCRT and survival among patients with local ESCC.All receiving followed by surgery NEOCRTEC5010-trial (NCT01216527) were included. Non-pCR classified...
Radioresistance remains a major obstacle to efficacious radiotherapy in non-small-cell lung cancer (NSCLC). DNA replication proteins are novel targets for radiosensitizers. POLQ is polymerase involved damage response and repair. We found that overexpressed NSCLC clinically correlated with high tumor stage, poor prognosis, increased mutational burden, ALK TP5 mutation status; inhibition impaired tumorigenesis. Notably, expression was higher radioresistant cells than wild-type cells. Moreover,...
Inverted flexible perovskite solar cells (PSCs) typically employ expensive metals as the counter electrodes, which are brittle and corrodible by perovskite, leading to a sharp performance drop under continuous bending, air exposure, thermal stress, or light illumination eventually retard commercialization. Herein, low-cost Bi2Te3 electrode was employed using simple evaporation process. The resultant device achieved an excellent power conversion efficiency of 18.16%, among highest reported...
Abstract Peritoneal adhesions are fibrous tissues formed after surgery. Both cytokines and transforming growth factors ( TGF s) involved in this process. The objective of study was to investigate the cross talk between these entities. drainage fluid surgery from patients rodent models examined by enzyme‐linked immunosorbent assay fluorescence‐activated cell sorter. Data showed that concentrations interferon IFN )‐γ interleukin IL )‐17 reached their peaks 6–12 hours surgery, whereas ‐β1 two...
Antisolvent-assisted crystallization has been extensively used for perovskite solar cells (PSCs), although this approach a fatal drawback, low reproducibility, originating from the extremely harsh operating conditions of current antisolvents. As result, only skilled technicians are qualified to be scheduled prepare thin films fabricate high-efficiency devices, which lowers pace progress PSCs. Besides, most popular antisolvents toluene (TL) and chlorobenzene (CB) highly toxic carcinogenic. On...
Abstract The aim of this study was to evaluate the association between overweight and severity, drug response, clinical outcomes novel coronavirus disease 2019 (COVID-19). In retrospective cohort study, we reviewed medical records 240 COVID-19 patients admitted Union Hospital in Wuhan, China, December 24, 2019, March 25, 2020. Physical, clinical, laboratory, radiological characteristics, treatment, outcome data were abstracted. Patients who obese [body mass index (BMI) ≥28 kg/m 2 ],...
Abstract High dielectric constant Ba 4 (Pr 0.4 Sm 0.6 ) 28/3 Ti 18− y Ga /3 O 54 (BPSTG) (0 ≤ 1) microwave ceramics with enhanced properties were synthesized via the traditional solid‐state processing for first time. The crystal structure, microstructure, and characteristics investigated in details. X‐ray diffraction results showed that all well‐sintered samples belonged to a single tungsten bronze type phase. Results partial substitution of 3+ 4+ is an effective way adjusting temperature...