A5047076761- Air Quality and Health Impacts
- HIV Research and Treatment
- interferon and immune responses
- Atmospheric chemistry and aerosols
- CRISPR and Genetic Engineering
- Poxvirus research and outbreaks
- Bacillus and Francisella bacterial research
- Plant Virus Research Studies
- COVID-19 epidemiological studies
- Viral Infections and Immunology Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Immune Cell Function and Interaction
- Remote Sensing and Land Use
- SARS-CoV-2 and COVID-19 Research
- Environmental Changes in China
- Data-Driven Disease Surveillance
- Soil and Land Suitability Analysis
- 2D Materials and Applications
- Air Quality Monitoring and Forecasting
- Complex Network Analysis Techniques
- Environmental Quality and Pollution
- Viral Infections and Vectors
- Advanced Photocatalysis Techniques
- RNA regulation and disease
- Antibiotic Resistance in Bacteria
Tianjin University
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2010-2024
Heilongjiang Provincial Hospital
2024
Ministry of Agriculture and Rural Affairs
2024
Zhejiang University
2007-2024
Tsinghua University
2024
Tianjin Normal University
2019-2022
Drexel University
2020-2021
Taishan University
2015-2019
National University of Defense Technology
2010-2018
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the unprecedented disease 2019 (COVID-19) pandemic. Critical cases of COVID-19 are characterized by production excessive amounts cytokines and extensive lung damage, which is partially fusion SARS-CoV-2-infected pneumocytes. Here, we found that cell SARS-CoV-2 spike (S) protein induced a type I interferon (IFN) response. This function S required its cleavage proteases at S1/S2 S2' sites. We further showed damaged nuclei...
The SAM domain and HD containing protein 1 (SAMHD1) inhibits retroviruses, DNA viruses long interspersed element (LINE-1). Given that in dividing cells, SAMHD1 loses its antiviral function yet still potently restricts LINE-1, we propose that, instead of blocking viral synthesis by virtue dNTP triphosphohydrolase activity, may exploit a different mechanism to control LINE-1. Here, report new activity promoting cellular stress granule assembly, which correlates with increased phosphorylation...
The cyclic GMP-AMP (cGAMP) synthase (cGAS) is a key DNA sensor that initiates STING-dependent signaling to produce type I interferons through synthesizing the secondary messenger 2′3′-cGAMP. In this study, we confirm previous studies showing cGAS located both in cytoplasm and nucleus. Nuclear accumulation observed when leptomycin B used block exportin, CRM1 protein. As result, impairs production of response stimulation. We further identify functional nuclear export signal (NES) cGAS,...
Abstract Background Ferroptosis and iron-metabolism are regulated by Long non-coding RNAs (lncRNAs) in ovarian cancer (OC). Therefore, a comprehensive analysis of ferroptosis related lncRNAs (FIRLs) OC is crucial for proposing therapeutic strategies survival prediction. Methods In multi-omics data from patients, FIRLs were identified calculating Pearson correlation coefficients with genes (FIRGs). Cox-Lasso regression was performed on the to screen further participating signature. addition,...
Mpox is caused by a zoonotic virus belonging to the Orthopoxvirus genus and Poxviridae family. In this study, we develop recombinase polymerase amplification (RPA)-coupled CRISPR-Cas12a detection assay for mpox virus. We design test series of CRISPR-derived RNAs(crRNAs) targeting conserved D6R E9L genes orthopoxvirus unique N3R N4R viruses. crRNA-1 exhibits most robust activity in detecting orthopoxviruses, crRNA-2 able distinguish from other orthopoxviruses. The Cas12a/crRNA alone presents limit 10
Abstract : During the last 15 years, operational oceanography systems have been developed in several countries around world. These developments fostered primarily by Global Ocean Data Assimilation Experiment (GODAE), which coordinated these activities, encouraged partnerships, and facilitated constructive competition. This multinational coordination has very beneficial for development of oceanography. Today, provide routine, real-time ocean analysis, forecast, reanalysis products. are based...
CRISPR-Cas provides bacteria and archaea with immunity against invading phages foreign plasmid DNA has been successfully adapted for gene editing in a variety of species. The class 2 type VI effector Cas13a targets cleaves RNA, providing protection RNA phages. Here we report the repurposing CRISPR-Cas13a to inhibit human immunodeficiency virus 1 (HIV-1) infection through targeting HIV-1 diminishing viral expression. We observed strong inhibition by cells. showed that not only diminishes...
Cyclic GMP-AMP synthase (cGAS) is a major sensor of cytosolic DNA from invading pathogens and damaged cellular organelles. Activation cGAS promotes liquid-like phase separation formation membraneless cytoplasmic structures. Here, we found that bound G3BP1, double-stranded nucleic acid helicase involved in the stress granules. Loss G3BP1 blocked subcellular condensation suppressed interferon response to intracellular virus particles cells. Furthermore, an RNA-dependent association with PKR...
Among persons born in China before 1980 and tested for vaccinia virus Tiantan strain (VVT), 28.7% (137/478) had neutralizing antibodies, 71.4% (25/35) memory B-cell responses, 65.7% (23/35) T-cell responses to VVT. Because of cross-immunity between the viruses, these findings can help guide mpox vaccination strategies China.
Since May 2022, the multi-country outbreak of monkeypox (mpox) has raised a great concern worldwide. Early detection mpox virus infection is recognized as an efficient way to prevent transmission. Mpox specific methods reported up now are based on SNPs among and other orthopoxviruses. We have therefore developed real-time PCR method targeting sequences (N3R B18Rplus). also optimized orthopoxvirus system which targets highly conserved E9L D6R genes. The assays high sensitivity (1...
SARS-CoV-2 has become a global threat to public health. Infected individuals can be asymptomatic or develop mild severe symptoms, including pneumonia, respiratory distress, and death. This wide spectrum of clinical presentations infection is believed in part due the polymorphisms key genetic factors population. In this study, we report that interferon-induced antiviral factor IFITM3 inhibits by preventing spike-protein-mediated virus entry cell-to-cell fusion. Analysis Chinese COVID-19...
Abstract The mpox outbreak has subdued with fewer reported cases at the present in high‐income countries. It is known that virus (MPXV) infection been epidemic for more than 50 years African ancestral MPXV strain changed into multiple clades, indicating ongoing evolution of MPXV, which reflects historical neglect Africa, especially after smallpox eradication, and bestows danger severe epidemics future. thus imperative to continue development diagnostics treatments so we can be prepared event...
Rooftop photovoltaics (RPVs) are crucial in addressing energy shortages and environmental concerns caused by fossil fuel combustion. To promote the optimal deployment of RPVs Tianjin, a region with abundant solar resources dense buildings, this study proposes framework that integrates building vector data deep learning model to extract currently installed from remote sensing images, further estimate development potential RPVs. A total 86,363 RPV polygons were extracted, covering an area...
Existing studies on the propagation of infectious diseases have not sufficiently considered uncertainties that are related to individual behavior and its influence decision making prevent infections, even though it is well known changes in can lead variations macrodynamics spread diseases. These influencing factors be categorized into emotion-related cognition-related components. We present a fuzzy cognitive map (FCM) denotative model describe how emotions cognition each other. adjust weight...
CRISPR/Cas9 is an adaptive immune system where bacteria and archaea have evolved to resist the invading viruses plasmid DNA by creating site-specific double-strand breaks in DNA. This study tested this gene editing inhibiting human immunodeficiency virus type 1 (HIV-1) infection targeting viral long terminal repeat coding sequences. Strong inhibition of HIV-1 Cas9/gRNA was observed, which resulted not only from insertions deletions (indels) that were introduced into due Cas9 cleavage, but...
Sifuvirtide, a novel fusion inhibitor against human immunodeficiency virus type I (HIV-1), which is more potent than enfuvirtide (T20) in cell culture, currently under clinical investigation for the treatment of HIV-1 infection. We now report that vitro selection variants resistant to sifuvirtide presence increasing concentrations has led several specific mutations gp41 region had not been previously reported. Many these substitutions were confined N-terminal heptad repeat at positions 37,...
With the exponential growth in world population and constant increase human mobility, possible impact of outbreaks epidemics on cities is increasing, especially high-density urban areas such as public transportation transfer points. The volume proximity people these can lead to an observed dramatic transmission airborne viruses related pathogens. Due critical role play transmission, it vital that we have a comprehensive understanding 'transmission highways' predict or prevent spreading...