A5100646825- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- Autophagy in Disease and Therapy
- HIV Research and Treatment
- RNA modifications and cancer
- Cardiac Ischemia and Reperfusion
- MicroRNA in disease regulation
- Neurological Disease Mechanisms and Treatments
- HIV/AIDS drug development and treatment
- Anesthesia and Neurotoxicity Research
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- S100 Proteins and Annexins
- Immune Cell Function and Interaction
- NF-κB Signaling Pathways
- Organ Transplantation Techniques and Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Liver Disease and Transplantation
- HIV/AIDS Research and Interventions
- Neuroscience and Neuropharmacology Research
- Peptidase Inhibition and Analysis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Toxin Mechanisms and Immunotoxins
- Inflammasome and immune disorders
- interferon and immune responses
Bristol-Myers Squibb (United States)
2010-2025
Bristol-Myers Squibb (Germany)
2010-2025
Second Affiliated Hospital of Nanchang University
2018-2024
Nanchang University
2018-2024
Tulane University
2020-2024
Xuzhou Medical College
2015-2024
Augusta University Health
2023-2024
Zhejiang University
2024
Gansu Agricultural University
2021-2024
Harbin Medical University
2024
Toll-like receptor 4 (TLR4) contributes to cerebral ischemia/reperfusion (I/R) injury and is a potential target for the treatment of ischemic stroke. This experiment evaluate effect an exogenous TLR4 antagonist, TAK-242, against acute I/R injury. A mouse model was induced by transient middle artery occlusion. TAK-242 (3 mg/kg body weight) injected intraperitoneally 1 hour after ischemia. Our results showed that concentration in plasma increased 52.0 ng/mL 3 hours injection, maintained at...
The ability of lipopolysaccharide (LPS) pre-treatment to induce cardioprotection following ischaemia/reperfusion (I/R) has been well documented; however, the mechanisms have not fully elucidated. LPS is a Toll-like receptor 4 (TLR4) ligand. Recent evidence indicates that there cross-talk between TLR and phosphoinositide 3-kinase/Akt (PI3K/Akt) signalling pathways. We hypothesized activation PI3K/Akt plays critical role in LPS-induced cardioprotection.To evaluate this hypothesis, we...
Abstract TLRs play a critical role in the induction of innate and adaptive immunity. However, have also been reported to mediate pathophysiology organ damage following ischemia/reperfusion (I/R) injury. We that TLR4−/− mice show decreased myocardial injury I/R; however, protective mechanisms not elucidated. examined PI3K/Akt signaling pathway cardioprotection I/R age-matched wild-type (WT) were subjected ischemia for 45 min, followed by reperfusion 4 h. Pharmacologic inhibitors PI3K...
Allogeneic hematopoietic stem cell transplantation (HSCT) is one of curative treatment options for patients with hematologic malignancies. Although GVHD mediated by the donor’s T lymphocytes remains most challenging toxicity allo-HSCT, graft-versus-leukemia (GVL) effect targeting leukemic cells, has an important role in affecting overall outcome AML. Here we comprehensively characterized TCR repertoire who underwent matched donor or haplo-cord HSCT using next-generation sequencing approach....
Carvacrol (CAR), a naturally occurring monoterpenic phenol and food additive, has been shown to have antimicrobials, antitumor, antidepressant-like activities. A previous study demonstrated that CAR the ability protect liver against ischemia/reperfusion injury in rats. In this study, we investigated protective effects of on cerebral middle artery occlusion mouse model. We found (50 mg/kg) significantly reduced infarct volume improved neurological deficits after 75 min ischemia 24 h...
Abstract Induced pluripotent stem cells (iPSCs) can be efficiently differentiated into retinal pigment epithelium (RPE), offering the possibility of autologous cell replacement therapy for degeneration stemming from RPE loss. The generation and maintenance epithelial apical-basolateral polarity is fundamental iPSC-derived (iPSC-RPE) to recapitulate native structure function. Presently, no criteria have been established determine clonal or donor based heterogeneity in polarization maturation...
BMS-378806 is a recently discovered small-molecule human immunodeficiency virus type 1 (HIV-1) attachment inhibitor with good antiviral activity and pharmacokinetic properties. Here, we demonstrate that the compound targets viral entry by inhibiting binding of HIV-1 envelope gp120 protein to cellular CD4 receptors via specific competitive mechanism. binds directly at stoichiometry approximately 1:1, affinity similar soluble CD4. The potential target site was localized region within pocket...
BMS-488043 is a small-molecule human immunodeficiency virus type 1 (HIV-1) CD4 attachment inhibitor with demonstrated clinical efficacy. The compound inhibits soluble (sCD4) binding to the 11 distinct HIV envelope gp120 proteins surveyed. Binding of and that sCD4 are mutually exclusive, since increased concentrations one can completely block other without affecting maximal capacity. Similarly, inhibited virion trimers from sCD4-immunoglobulin G (IgG), decreasing inhibition as sCD4-IgG...
Azaindole derivatives derived from the screening lead 1-(4-benzoylpiperazin-1-yl)-2-(1H-indol-3-yl)ethane-1,2-dione (1) were prepared and characterized to assess their potential as inhibitors of HIV-1 attachment. Systematic replacement each unfused carbon atoms in phenyl ring indole moiety by a nitrogen atom provided four different azaindole that displayed clear SAR for antiviral activity all which marked improvements pharmaceutical properties. Optimization these leads resulted...
Traumatic brain injury (TBI) causes acute inflammatory responses that result in an enduring cascade of secondary neuronal loss and behavioral impairments. It has been reported progesterone (PROG) can inhibit the increase some cytokines inflammation-related factors induced by TBI. Toll-like receptors (TLRs) play a critical role induction regulation immune/inflammatory responses. Therefore, present study, we examined genomic profiles TLR-mediated pathways traumatically injured PROG's effects...
Plasminogen activator inhibitor-1 (PAI-1) is a protease inhibitor but paradoxically associated with poor outcomes in cancer patients. However, the mechanisms of its effects on tumor cells have not been explored.
Inflammation is an important component of the response to traumatic brain injury (TBI). Progesterone has been shown inhibit neuroinflammation following (TBI) and may do so through Toll-like receptor (TLR)-mediated pathways. In vitro studies indicate that 1,25-dihydroxyvitamin D(3) (VDH) also modulate inflammatory TLR4 pathway. This study tested hypothesis PROG VDH would exert additive synergistic neuroprotective effects compared with individual treatment by modulating TLR4/NF-κB-mediated...
Immune responses play a critical role in various disease conditions including cancer and autoimmune diseases. However, to date, there has not been rapid, sensitive, comprehensive, quantitative analysis method examine T-cell or B-cell immune responses. Here, we report new approach characterize T cell receptor (TCR) repertoire by sequencing millions of cDNA TCR α β chains combination with newly-developed algorithm. Using samples from lung patients treated peptide vaccines as model, demonstrate...