A5069422752- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- S100 Proteins and Annexins
- Environmental Toxicology and Ecotoxicology
- Neurological Disease Mechanisms and Treatments
- Anesthesia and Neurotoxicity Research
- Cardiac Arrest and Resuscitation
- Acute Ischemic Stroke Management
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Glioma Diagnosis and Treatment
- Immune Response and Inflammation
- Traumatic Brain Injury Research
- Heme Oxygenase-1 and Carbon Monoxide
- Neurological Disorders and Treatments
- Trace Elements in Health
- Selenium in Biological Systems
- Neurogenesis and neuroplasticity mechanisms
- Medicinal Plants and Neuroprotection
- Brain Metastases and Treatment
- Mitochondrial Function and Pathology
- Neuropeptides and Animal Physiology
- Menopause: Health Impacts and Treatments
- Vitamin D Research Studies
- Pesticide Exposure and Toxicity
Emory University
2014-2023
Neurological Surgery
2022
Morehouse School of Medicine
2022
Emory Healthcare
2013
Hamdard University
2005-2010
Jamia Hamdard
2004-2010
University of Nebraska Medical Center
2007-2009
Traumatic brain injury (TBI) causes acute inflammatory responses that result in an enduring cascade of secondary neuronal loss and behavioral impairments. It has been reported progesterone (PROG) can inhibit the increase some cytokines inflammation-related factors induced by TBI. Toll-like receptors (TLRs) play a critical role induction regulation immune/inflammatory responses. Therefore, present study, we examined genomic profiles TLR-mediated pathways traumatically injured PROG's effects...
Inflammation is an important component of the response to traumatic brain injury (TBI). Progesterone has been shown inhibit neuroinflammation following (TBI) and may do so through Toll-like receptor (TLR)-mediated pathways. In vitro studies indicate that 1,25-dihydroxyvitamin D(3) (VDH) also modulate inflammatory TLR4 pathway. This study tested hypothesis PROG VDH would exert additive synergistic neuroprotective effects compared with individual treatment by modulating TLR4/NF-κB-mediated...
Because the complex heterogeneity of traumatic brain injury (TBI) is believed by many to be a major reason for failed clinical trials monotherapies, combining two (or more) drugs with some potentially different mechanisms action may produce better effects than administering those agents individually. In this study, we investigated whether combinatorial treatment progesterone (PROG) and 1,25-dihydroxyvitamin D3 hormone (VDH) would neuroprotection PROG alone following excitotoxic neuronal in...
Patients enrolled in clinical trials for traumatic brain injury (TBI) may present with heterogeneous features over a range of severity, such as diffuse axonal injury, ischemia, edema, hemorrhage, oxidative damage, mitochondrial and metabolic dysfunction, excitotoxicity, inflammation, other pathophysiological processes. To determine whether combination therapies might be more effective than monotherapy at attenuating moderate TBI or promoting recovery, the National Institutes Health funded...
NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome inhibition and autophagy induction attenuate inflammation improve outcome in rodent models of cerebral ischemia. However, the impact chronic stress on NLRP3 autophagic response to ischemia remains unknown. Progesterone (PROG), a neuroprotective steroid, shows promise reducing excessive associated with poor ischemic brain injury patients comorbid conditions, including elevated stress. Stress primes microglia, mainly by release...
Studies from a single laboratory have shown that in rodent models of permanent stroke, administration the sulfonylurea glibenclamide (Glib) is highly effective reducing edema, mortality, and lesion volume. The Stroke Therapy Academic Industry Roundtable (STAIR) recommends new acute treatments for ischemic stroke to be replicated across different laboratories. Accordingly, we examined effect low-dose Glib suture occlusion model stroke. Male Sprague-Dawley rats underwent middle cerebral artery...
We evaluated the neuroprotective effects of delayed progesterone (PROG) treatment against ischemic stroke-induced neuronal death, inflammation, and functional deficits. induced transient focal cerebral ischemia in male rats administered PROG (8 mg/kg) or vehicle intraperitoneally at 3, 6, 24 hours post occlusion, subcutaneously 5 later then every for 7 days. Behavioral outcomes were over 22 Infarct size other biomarkers injury by cresyl violet staining, matrix metalloproteinase-9 (MMP-9),...