A5100755246- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Intraocular Surgery and Lenses
- Ophthalmology and Visual Impairment Studies
- Retinal Imaging and Analysis
- Cerebral Venous Sinus Thrombosis
- Ophthalmology and Eye Disorders
- Optical Imaging and Spectroscopy Techniques
- Connexins and lens biology
- Retinal and Macular Surgery
- Photoreceptor and optogenetics research
- Neurological Disorders and Treatments
- Medical Imaging and Analysis
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Optical Coherence Tomography Applications
- Ocular Oncology and Treatments
- MRI in cancer diagnosis
- Nitric Oxide and Endothelin Effects
- Corneal Surgery and Treatments
- Musculoskeletal pain and rehabilitation
- Neuroscience and Neuropharmacology Research
Tongji University
2013-2025
Shanghai Tenth People's Hospital
2025
Legacy Health
2014-2024
Chinese PLA General Hospital
2024
Nankai University
2024
Capital Medical University
2024
Guangzhou University of Chinese Medicine
2024
University of Bern
2023
Third Hospital of Hebei Medical University
2023
West China Hospital of Sichuan University
2007-2023
To characterize optic nerve head (ONH) blood flow (BF) changes in nonhuman primate experimental glaucoma (EG) using laser speckle flowgraphy (LSFG) and the microsphere method to evaluate correlation between two methods.EG was induced one eye each of 9 rhesus macaques by treatment trabecular meshwork. Prior lasering following onset intraocular pressure (IOP) elevation, retinal never fiber layer thickness (RNFLT) ONH BF were measured biweekly spectral-domain optical coherence tomography LSFG,...
purpose. To describe varicosities of intraretinal ganglion cell axons in the nerve fiber layer human and nonhuman primate retinas. methods. Intraretinal seven donors (1–85 years old) two primates (Macaca mulatta, 15 17 were immunohistochemically stained with an antibody neurofilament on flatmounted retinas examined light microscopy. In addition, within retinal transmission electron microscopy one retina. The variations diameters single measured transverse- parallel-cut sections, frequency...
To compare peripapillary retinal nerve fiber layer thickness (RNFLT), RNFL retardance, and function at the onset of optic head (ONH) surface topography change in experimental glaucoma (EG).Thirty-three rhesus macaques had three or more weekly baseline measurements both eyes ONH topography, RNFLT, multifocal electroretinography (mfERG). Laser photocoagulation was then applied to trabecular meshwork one eye induce chronic elevation IOP recordings continued alternating between RNFLT during week...
Longitudinal measurements of peripapillary RNFL thickness and retardance were compared in terms time to reach onset damage a specific progression endpoint.A total 41 rhesus macaques with unilateral experimental glaucoma (EG) each had three or more weekly baseline both eyes (RNFLT) retardance. Laser photocoagulation was then applied the trabecular meshwork one eye induce chronic elevation intraocular pressure imaging continued. Pairwise differences between observations sampled by...
Glucose metabolism in the outer retina of pigs was studied light and dark pentobarbital anaesthetized pigs. Blood collected from a vortex vein an artery. arteriovenous concentration differences lactate, glucose oxygen were determined lightadapted eyes. Local blood flows simultaneously using microsphere method. In second group experiments. flow measured both darkness light. mean net lactate formation consumption about 0.137. 0.150 0.1151 µol min ‐1 respectively. eyes previously dark‐adapted....
Despite significant improvements in life expectancy of kidney transplant patients due to advances surgery and immunosuppression, Chronic Allograft Nephropathy (CAN) remains a daunting problem. A complex network cellular mechanisms both graft peripheral immune compartments complicates the non-invasive diagnosis CAN, which still requires biopsy histology. This is compounded by non-immunological factors contributing injury. There pressing need identify validate minimally invasive biomarkers for...
Abstract Introduction Earlier work indicates that the cholesterol-lowering drug, simvastatin, is anabolic to chondrogenic expression of rat intervertebral disc (IVD) cells, which suggests a potential role for simvastatin in IVD regeneration. In this study, we expand on our earlier test effectiveness degeneration utilizing tail model. Methods 30 rats underwent 21 G needle-puncture at discs were injected with simvastatin-loaded poly(ethylene glycol)-poly(lactic acid-co-glycolic...
To compare in vivo retinal nerve fiber layer thickness (RNFLT) and axonal transport at 1 2 weeks after an 8-hour acute IOP elevation rats.Forty-seven adult male Brown Norway rats were used. Procedures performed under anesthesia. The was manometrically elevated to 50 mm Hg or held 15 (sham) for 8 hours unilaterally. RNFLT measured by spectral-domain optical coherence tomography. Anterograde retrograde assessed from confocal scanning laser ophthalmoscopy imaging 24 bilateral injections of μL...
PURPOSE. To evaluate the effect of acutely elevated intraocular pressure (IOP) on retinal thickness and optic nerve head (ONH) structure in rat eye by spectral domain-optical coherence tomography (SD-OCT). METHODS. Fourteen adult male Brown-Norway rats were studied under anesthesia (ketamine/xylazine/acepromazine, 55:5:1 mg/kg intramuscularly). Both eyes imaged SD-OCT two baseline occasions several weeks before again 2 4 after acute IOP imaging session. During session, was performed 10...
To relate changes in retinal function and nerve fiber layer (RNFL) retardance to loss of RNFL thickness optic axon counts a nonhuman primate (NHP) model experimental glaucoma (EG).Bilateral longitudinal measurements peripapillary (spectral-domain optical coherence tomography, SDOCT; Spectralis), (GDxVCC), multifocal electroretinography (mfERG; VERIS) were performed 39 NHP at baseline (BL; median, 5 recordings; range, 3-10) weekly after induction unilateral EG by laser photocoagulation the...
Euphorbia tirucalli is a long‑established treatment for wide variety of cancers. However, the mechanism its anticancer effect yet to be elucidated. In present study, we examined euphol, tetracyclic triterpene alcohol isolated from sap tirucalli, in T47D human breast cancer cells. Following cells with different doses euphol 24, 48 and 72 h, cell proliferation, cycle, mRNA protein levels cycle regulatory molecules were analyzed, respectively. Treatment resulted decreased viability, which was...
INTRODUCTION Central venous catheters (CVCs) are commonly utilized to gain vascular access for varied clinical indications. These include administering drugs, renal replacement therapy, total parenteral nutrition, poor peripheral access, cardiac catheterization, and transvenous pacing.[1] involves a large bore catheter inserted in internal jugular, subclavian or femoral vein the neck, upper chest groin (femoral) area.[1] The preferred CVCs is right jugular (IJV) its straight course heart...
Total thymectomy should be performed on thymoma patients with myasthenia gravis. The aim of the present study was to investigate risk factors postoperative myasthenic crisis (POMC) occurrence in these patients. clinical records 127 gravis (68 men, 59 women; median age, 50 years) who underwent total at our institution from 2005 2014 were retrospectively reviewed. following analysed relation POMC: gender, duration symptoms, bulbar smoking history, history crisis, comorbidities, perioperative...
We tested the hypothesis that experimental glaucoma (EG) results in greater thinning of optic nerve head (ONH) neural rim tissue than peripapillary retinal fiber layer (RNFL) tissue.Longitudinal spectral-domain optical coherence tomography (SDOCT) imaging ONH and RNFL was performed every other week under manometric IOP control (10 mm Hg) 51 nonhuman primates (NHP) during baseline after induction unilateral EG. The parameter minimum area (MRA) derived from 80 radial B-scans centered on ONH;...
Objective: To evaluate the efficacy and safety of fecal microbiota transplantation (FMT) for treating functional constipation, analyze incidence of, factors that influence, adverse events, provide scientific evidence optimizing FMT treatment. Methods: This retrospective, multicenter, single-arm, pre-post real-world study included 1529 patients with constipation from four clinical centers. Eligibility criteria comprised meeting diagnostic having undergone at least one treatment, complete pre-...
Abstract Purpose: To elucidate the role of nitric oxide (NO) in eye and flicker‐induced vascular response. Methods: The blood flow retina different parts optic nerve was compared cats treated with NO‐synthase blocker, N G ‐nitro‐L‐arginine methyl ester control animals. In both groups, one eyes dark‐adapted, other subjected to 8 Hz flickering light. regional measured microsphere method. Results: animals, light increased head by 39% 256%, respectively. Pretreatment prevented this increase...
AbstractThe effects of intravitreal and intracameraJ administration endothelin-1 were studied in the anaesthetized cat. Intravitreal injection 0.4 nmol induced a 34±10% (n=5; P<0.05) reduction retinal blood flow experimental eye compared to control 80 minutes after injection. Blood ciliary body, iris choroid remained unaffected by endothelin-1.Intracameral at pmol doses caused pupil size, an increase aqueous humor protein concentration (indicating break-down blood-aqueous barrier)...
Pigment epithelium-derived factor (PEDF) was identified from retinal pigment epithelial cells and has been shown to display neurotrophic effects. In addition it found induce a potent inhibition of angiogenesis. this study we have explored whether overexpression PEDF by gene transfer approach can block tumor angiogenesis reduce growth. We that infected with an adenovirus encoding under the control CMV promoter (AdPEDF) secreted protein into medium exhibited strong inhibitory effects on...
Studies suggest that reduced ocular perfusion pressure in the optic nerve head (ONH) increases risk of glaucoma. This study tested a hypothesis magnitude blood flow change ONH induced between two same intraocular (IOP) alterations depends on level mean systemic (BP).In eight anesthetized rhesus monkeys, BP was maintained at either high, medium, or low (n = 6 each, ranging from 51-113 mm Hg); IOP rapidly altered 10 to 30 Hg and then manometrically. Blood (BF(ONH)) repeatedly measured with...