A5029209186- Vitamin D Research Studies
- Heavy Metal Exposure and Toxicity
- Diet and metabolism studies
- Air Quality and Health Impacts
- Cancer Cells and Metastasis
- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Gut microbiota and health
- Ovarian cancer diagnosis and treatment
- Water Treatment and Disinfection
- Trace Elements in Health
- Nutritional Studies and Diet
- Bone health and treatments
- Estrogen and related hormone effects
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Birth, Development, and Health
- Effects of Radiation Exposure
- Nanoplatforms for cancer theranostics
- Cancer-related molecular mechanisms research
- Vitamin C and Antioxidants Research
- Cytokine Signaling Pathways and Interactions
- Digestive system and related health
- Per- and polyfluoroalkyl substances research
- Effects and risks of endocrine disrupting chemicals
Soochow University
2016-2025
Soochow University
2016-2025
Anyang Hospital of Traditional Chinese Medicine
2019-2025
Northeast Agricultural University
2024
Second Affiliated Hospital of Soochow University
2013-2022
Xi'an Polytechnic University
2022
Air Force Medical University
2019
Xijing Hospital
2019
Suzhou Research Institute
2018
In-Q-Tel
2018
Carvacrol (CAR), a naturally occurring monoterpenic phenol and food additive, has been shown to have antimicrobials, antitumor, antidepressant-like activities. A previous study demonstrated that CAR the ability protect liver against ischemia/reperfusion injury in rats. In this study, we investigated protective effects of on cerebral middle artery occlusion mouse model. We found (50 mg/kg) significantly reduced infarct volume improved neurological deficits after 75 min ischemia 24 h...
Abstract Sonodynamic therapy (SDT) is considered a reliable replacement to overcome the resistance antibiotics and limited tissue penetration of traditional photo‐induced therapy. Herein, ultrasmall platinum‐copper alloy nanoparticles (PtCu NPs) modified with poly (maleic anhydridealt‐1‐octadecene)‐polyethylene glycol (C 18 PMH‐PEG) high sonodynamic activity, strong catalytic ability, good glutathione (GSH) depletion performance are synthesized for highly efficient bacterial elimination....
Abstract Background Long-term exposure to air pollution has been found contribute the development of cognitive decline. Our study aimed assess association between various pollutants and impairment dementia. Additionally, explore modification effects lifestyle genetic predisposition. Methods The levels pollutants, including particulate matter (PM) with diameters ≤ 2.5 (PM ), 10 μm 2.5−10 ) nitrogen oxides (NO NO 2 were identified. An score (APS) was calculated evaluate combined these five...
ABSTRACT The active vitamin D‐degrading enzyme (CYP24A1) is commonly overexpressed in various types of cancer, which associated with poor prognosis cancer patients. Recent studies highlight the antagonism CYP24A1 toward anticancer role D. However, impact on tumorigenesis and its underlying mechanisms largely remains unexplored. This study also found that high mRNA expressions were ovarian lung adenocarcinoma (LUAD) Moreover, we demonstrated overexpression accelerated proliferation,...
Osteosarcoma (OS), a highly aggressive bone tumor, presents significant challenges in terms of effective treatment. We identified that cellular autophagy was impaired within OS by comparing clinical samples through bioinformatic analyses and further validated the inhibition mitochondrial at transcriptomic level. Based on this finding, we investigated therapeutic potential dual functional metal nanoplatform (MnSx) to facilitate transition from protective effect low-level killing high-level...
Abstract To understand the chronic spleen injury induced by intragastric administrations with 2.5, 5, and 10 mg kg −1 body weight titanium dioxide nanoparticles (TiO 2 NPs) for 90 consecutive days, histopathological ultrastructure changes, hematological parameters, lymphocyte subsets, inflammatory, apoptotic cytokines in mouse were investigated. Our findings indicate that TiO NPs exposure results significant increase indices, splenocyte apoptosis spleen. Especially, these NPs‐treated mice,...
Although liver toxicity induced by titanium dioxide nanoparticles (TiO2 NPs) has been demonstrated, very little is known about the molecular mechanisms of multiple genes working together underlying this type injury in mice. In study, we used whole-genome microarray analysis technique to determine gene expression profile livers mice exposed 10 mg/kg body weight TiO2 NPs for 90 days. The findings showed that long-term exposure resulted obvious accumulation and NP aggregation hepatocyte nuclei,...
Although recent evidence shows that long noncoding RNAs (lncRNAs) are involved in the regulation of gene expression and cancer progression, understanding role lncRNAs lung metastasis is still limited. To identify novel non-small cell (NSCLC), we profile NSCLC tumor matched normal samples using GeneChip® Human Gene 2.0 ST Array, which provides most accurate, sensitive, comprehensive measurement protein coding lncRNA transcripts. We identified a panel key factors dysregulated cancer. Among...
Oxidative stress, due to the disruption of balance between reactive oxygen species (ROS) generation and antioxidant defense system, plays an important role in pathogenesis rheumatoid arthritis (RA). Excessive ROS leads loss biological molecules cellular functions, release many inflammatory mediators, stimulate polarization macrophages, aggravate response, thus promoting osteoclasts bone damage. Therefore, foreign antioxidants would effectively treat RA. Herein, ultrasmall iron-quercetin...
Background: Stroke is the second leading cause of death and third disability in general population worldwide. However, changing trend ischemic stroke burden attributable to various dietary risk factors has not been fully revealed may contribute a better understanding epidemiology. Aims: Our article aimed evaluate temporal diet-related inform future research policy-making. Methods: This analysis was based on data from Global Burden Disease (GBD) Study 2019 (spanning years 1990 2019), we used...
Lead (Pb) is a widespread toxic endocrine disruptor that could cause liver damage and gut microbiota dysbiosis.
Our previous study showed that heavy metal lead (Pb) exposure exacerbates high-fat-diet (HFD)-induced metabolic damage and significantly depletes the gut microbiota-derived metabolite short-chain fatty acid (SCFA) levels. However, it remains unclear whether SCFA is a key involved in accelerating adverse consequences after Pb exposure. In this study, we explored effects of exogenous supplementation acetate, propionate, butyrate on disorder model Pb-exposed HFD mice. We found three...