A5080386204- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Nanoplatforms for cancer theranostics
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Pancreatic and Hepatic Oncology Research
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Statistical Methods and Bayesian Inference
- Advanced Causal Inference Techniques
- Medicinal Plant Pharmacodynamics Research
- RNA modifications and cancer
- Gut microbiota and health
- CAR-T cell therapy research
- Radiopharmaceutical Chemistry and Applications
- Advanced Nanomaterials in Catalysis
- Statistical Methods and Inference
- Head and Neck Cancer Studies
- Extracellular vesicles in disease
- Innovative Education and Learning Practices
- Celiac Disease Research and Management
- Ovarian cancer diagnosis and treatment
Beijing Chest Hospital
2023
Capital Medical University
2023
Fudan University
2008-2023
Wuxi Fourth People's Hospital
2022-2023
Jiangnan University
2023
Soochow University
2022-2023
Second Affiliated Hospital of Soochow University
2022-2023
Tongji University
2022
Shanghai Tenth People's Hospital
2022
Sichuan University
2013-2021
Abstract Background Natural killer (NK) cells can kill tumor in a non-MHC-restricted manner. However, cancer frequently escape from the attack of NK by multiple ways. In this study, we investigated effect gefitinib on interaction between and lung cells. Methods 51 Cr release assay, CD107a IFN-γ secretion assay were performed to detect sensitivity cell lines A549 H1975 cytotoxicity presence gefitinib. Human co-cultured with NKG2D ligands, ULBP1, ULBP2, MICA, MHC-I cells, NKG2D, NKp44 NKp46...
Oxidative stress, due to the disruption of balance between reactive oxygen species (ROS) generation and antioxidant defense system, plays an important role in pathogenesis rheumatoid arthritis (RA). Excessive ROS leads loss biological molecules cellular functions, release many inflammatory mediators, stimulate polarization macrophages, aggravate response, thus promoting osteoclasts bone damage. Therefore, foreign antioxidants would effectively treat RA. Herein, ultrasmall iron-quercetin...
Monocyte chemotactic protein-1-induced protein 1 (MCPIP1) is highly expressed in inflamed mucosa of inflammatory bowel disease (IBD) and negatively regulates immune response, while the underlying mechanisms regulating mucosal macrophage functions remain unknown. Here, we investigated roles MCPIP1 modulating differentiation intestinal macrophages pathogenesis IBD.ScRNA-seq was used to cluster monocyte/macrophage lineage from macrophage-specific Mcpip1-deficient (Mcpip1∆Mye) mice Mcpip1fl/fl...
Proprotein convertase subtilisin/kexin type 9 (PCSK9) secreted by tumors was reported as a deleterious factor that led to the reduction of lymphocyte infiltration and poorer efficacy ICIs
Polymyositis (PM) and dermatomyositis (DM) are idiopathic inflammatory myopathies. Genetic variability in human leukocyte antigen (HLA) genes plays an important role the pathogenesis of PM DM. However, few studies on subject Chinese populations have been reported thus far. We studied influence HLA polymorphisms DM susceptibility by analyzing HLA-DRB1, HLA-DQA1, HLA-DQB1 alleles 71 adult patients, 20 113 controls a Han population. A positive association was found between HLA-DQA1*0104 (p =...
Sepsis is a systemic inflammatory response to infection, and early responses of macrophages are vital in controlling the infected microorganisms. We used cecal ligation puncture (CLP) model sepsis determine role cisplatin (0.1, 0.5 1 mg kg(-1)) with respect peritoneal macrophages, peritoneal/blood bacterial inflammation. found that mice which received low-dose (0.1 i.p. had lower mortality rate improved clinical scores compared normal saline-treated group, level IL-6 TNF-α was significantly...
Abstract Background The prevalence of colorectal cancer (CRC) worldwide is a huge challenge to human health. Primary tumor locations found impact prognosis and response therapy. important role gut microbiota in the progression treatment CRC has led many attempts alleviating chemotherapy-induced adverse effects using microecologics. However, underlying mechanism difference different primary synergistic effect prebiotics on chemotherapy need be further elucidated. This study aims explore...
We aim to investigate the anticancer effects and mechanisms of icaritin against breast cancer.Both estrogen receptor (ER) positive cancer cells MCF- 7 ER-negative MDA-MB-231 were employed. examined on proliferation migration by wound healing assay transwell assay. Cell apoptosis cell cycle MCF-7 analyzed using Flow cytometry. autophagy was assessed western blotting, acridine orange staining confocal microscopy. also detected expression apoptosis-related genes blotting. In addition, an...
This study aimed to evaluate the association between RRM1 and BRCA1 expressions therapeutic efficacy of platinum-based chemotherapy in non-small cell lung cancer patients terms their response prognosis. In total, 377 agreed participate our study, all them received combination January 2008 2009. The relative cDNA quantitation for was conducted using a fluorescence-based, real-time detection method, β-actin as reference gene. average age 64.6 years (range: 25.5-86.4 years), including 269 men...
Background: National guidelines recommend chemotherapy as the mainstay of treatment for stage IV colon cancer, with primary tumor resection (PTR) reserved patients symptomatic or curable disease. The aims this study were to characterize modalities received by cancer and determine patient-, tumor-, hospital-level factors associated those treatments. Methods: Patients diagnosed in 2014 extracted from SEER Patterns Care initiative. Treatments categorized into only, PTR + chemotherapy,...
We consider causal inference in randomized studies for survival data with a cure fraction and all-or-none treatment non compliance. To describe the effects, we complier average effect (CACE) on probability beyond time t (CESP), where CACE CESP are defined as difference of rate cured subjects' between control groups within class. These estimands depend distributions times groups. Given covariates latent compliance type, model these transformation promotion whose parameters estimated by...
In this article, causal inference in randomized studies with recurrent events data and all-or-none compliance is considered. We use the counting process to analyze propose a proportional intensity model. The maximum likelihood approach adopted estimate parameters of proposed To overcome computational difficulties created by mixture structure problem, we develop an expectation-maximization (EM) algorithm. resulting estimators are shown be consistent asymptotically normal. further complier...
Based on the Learning Community and Activity theories, study has set up a new model of Cross-Boundary Invitational for pre-service teacher education. From Self-Determination Theory perspective, we conducted questionnaire survey interview participants in university course teaching experiment. The results show that this promotes understanding mutual learning among participants, it specific promotion value higher