A5018208175- Seismic Performance and Analysis
- Inflammatory Bowel Disease
- Seismic and Structural Analysis of Tall Buildings
- Structural Engineering and Vibration Analysis
- Structural Behavior of Reinforced Concrete
- Structural Response to Dynamic Loads
- Structural Load-Bearing Analysis
- Immune Response and Inflammation
- Structural Health Monitoring Techniques
- Gut microbiota and health
- Geothermal Energy Systems and Applications
- IL-33, ST2, and ILC Pathways
- Geomechanics and Mining Engineering
- Geotechnical Engineering and Underground Structures
- Vibration and Dynamic Analysis
- Smart Agriculture and AI
- T-cell and B-cell Immunology
- Immune cells in cancer
- Immune Cell Function and Interaction
- Plant Disease Management Techniques
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Gas Sensing Nanomaterials and Sensors
- Microscopic Colitis
- Tunneling and Rock Mechanics
- Immunotherapy and Immune Responses
China Agricultural University
2024-2025
Henan University of Traditional Chinese Medicine
2024
Tongji University
2009-2024
Renmin Hospital of Wuhan University
2022-2024
Shanghai East Hospital
2024
Shanghai Institute of Pollution Control and Ecological Security
2024
Wuhan University
2022-2024
Shanghai Tenth People's Hospital
2021-2023
Jilin University
2006-2009
The University of Tokyo
2001
Dysregulated host-microbial interactions play critical roles in initiation and perpetuation of gut inflammation Crohn's disease (CD). However, the spatial distribution interaction network across intestine its accessory tissues are still elusive. Here, we profile host proteins tissue microbes 540 samples from intestinal mucosa, submucosa-muscularis-serosa, mesenteric adipose tissues, mesentery, lymph nodes 30 CD patients spatially decipher interactions. We observe aberrant antimicrobial...
Monocyte chemotactic protein-1-induced protein 1 (MCPIP1) is highly expressed in inflamed mucosa of inflammatory bowel disease (IBD) and negatively regulates immune response, while the underlying mechanisms regulating mucosal macrophage functions remain unknown. Here, we investigated roles MCPIP1 modulating differentiation intestinal macrophages pathogenesis IBD.ScRNA-seq was used to cluster monocyte/macrophage lineage from macrophage-specific Mcpip1-deficient (Mcpip1∆Mye) mice Mcpip1fl/fl...
Abstract Background Evidence has shown that the traditional Chinese herbal medicine Wumei decoction (WMD) a protective effect on ulcerative colitis. Here, we studied anti-inflammatory effects and potential mechanisms of WMD chronic colitis in mice. Methods A dextran sulfate sodium (DSS)–induced model CD45RBhighCD4+ T cell transfer were established Body weight, Disease Activity Index, colon length assessed, histopathology was confirmed by hematoxylin eosin staining. Colon tissue samples...
As a susceptibility gene for human inflammatory bowel diseases (IBD), how avian erythroblastosis virus E26 oncogene homolog-1 (ETS-1) modulates intestinal mucosal immune response remains unclear. Here we studied the potential roles of ETS-1 in pathogenesis IBD.ETS-1 expression was examined IBD patients. CD45RBhighCD4+ T cell-transfer colitis, dextran sulfate sodium (DSS)-induced and azomethane (AOM)/DSS-induced colitis-associated cancer (CAC) models were constructed to probe function vivo....
This study proposes a model for leafy vegetable disease detection and segmentation based on few-shot learning framework prototype attention mechanism, with the aim of addressing challenges complex backgrounds problems. Experimental results show that proposed method performs excellently in both object semantic tasks. In task, achieves precision 0.93, recall 0.90, accuracy 0.91, mAP@50 mAP@75 0.90. is 0.95, 0.92, 0.92. These significantly outperforms traditional methods, such as YOLOv10...
Neutrophils synergize with intestinal resident intraepithelial lymphocytes (IELs) to serve as the first-line defense and maintain homeostasis. However, underlying mechanisms whereby neutrophils regulate IELs inhibit inflammation are still not completely understood. Here, we found that depletion of (especially CD177
Understanding the cracking process of layered tunnels requires a high-fidelity method. Improved smooth particle hydrodynamics (SPH), termed kernel broken SPH (KBSPH), was implemented to simulate crack propagation and deformation rock cells field with dip angles 0°–90°, results were compared those laboratory tests. Three attempts, including bedding angle, interlayer distance, lateral pressure coefficient, made investigate tunnels. Finally, pros cons KBSPH method applied in other methods. The...
TOB1 is an anti-proliferative protein of Tob/BTG family and typically involved in the tumorigenesis T cell activation. Although associated with helper 17 cell-related autoimmunity, its role modulating cell-mediated immune responses IBD remains poorly understood. Here, we explored expression underlying mechanisms pathogenesis inflammatory bowel disease (IBD).TOB1 ID2 patients was examined by quantitative real time polymerase chain reaction immunohistochemistry. CD4+ cells were transfected...
A new seismic energy dissipation shear wall structure is proposed in this paper. The one with purposely built-in vertical slits within the panel, and rubber belts as devices are installed slits. In order to verify concept, shaking table tests of a 10-storey model filled were carried out, comparison behaviour was made between system reinforced concrete connecting beams dissipation. Furthermore, analysed by finite element time history analysis method. test show that has very good ability...
Background: Exclusive enteral nutrition (EEN) provides an effective strategy for the induction of clinical remission in pediatric Crohn's disease. However, feasibility long-term EEN management disease and underlying mechanism whereby prevents intestinal inflammation are still not fully understood. Methods: Paired male female adult wild-type (WT) mice were mated to breed littermates, these pups then weaned at 3 weeks age randomly allocated into regular diet (RT) feeding group (Peptisorb;...
A tendon model based on the finite-element method, that can represent interaction between and concrete of prestressed member, is proposed. Especially for multitendon cases, this capable simulating slip in duct so it deal with prestressing transfer posttensioned structures calculate unbonded more efficiently. Another relevant also proposed to friction bond at interface concrete. By using these models, a numerical procedure established material geometric nonlinear analysis structures,...
The present study describes a nonlinear analysis model developed for externally prestressed structures. This is capable of simulating the slip tendon on deviator and friction at interface deviator. Combing with concrete reinforcing steel models, computer program material geometric structures, based incremental load method, developed. numerical procedure can predict responses structures throughout their prestressing transfer service history, such as elastic plastic deformation, cracking,...
Primary nonresponse to infliximab in patients with ulcerative colitis (UC) is common. However, there are currently no effective biomarkers for this prediction. This study aimed identify potential predictors precision anti-tumor necrosis factor-alpha treatment UC. Four GPL570 datasets (GSE14580, GSE12251, GSE23597, and GSE16879) were included study. Sixty-nine differentially expressed genes (DEGs) identified, while 67 up-regulated two down-regulated by comparing the gene expression response...
Abstract Background Psoriasis is a chronic inflammatory skin disease that can cause systemic inflammation in various organs. Rutin has been suggested to fight psoriasis, but the signaling pathways by which it works need be explored. Materials and methods HaCaT cells co‐stimulated with interleukin (IL)‐17, IL‐22, tumor necrosis factor‐alpha (TNF‐α), IL‐1α, oncostatin M (M5) were used as an vitro cell model of psoriasis. The proliferation viability determined 5‐ethynyl‐2′‐deoxyuridine counting...
Reinforced concrete shear wall is one of the main lateral resistance members in tall buildings. A further understanding walls believed important to seismic design. To day, it recognized that boundary elements will contribute behavior walls, though extent still remains vague and evidence seldom given by relative experiment. Further-more, nonlinear capacity evaluation method also a difficulty, especially considering elements. This paper aims extend relevant existing studies with following two...
Shanghai International Design Center (SHIDC) is a hybrid structure of steel frame and reinforced concrete core tube (SF-RCC). It building unequal height two-tower system the story lateral stiffness two towers different, which may result in torsion effect. To fully evaluate structural behaviors SHIDC under earthquakes, NosaCAD, ABAQUS, Perform-3D, are widely applied for nonlinear analysis, were used to perform elastoplastic time history analyses. Numerical results compared with those shake...
A high four‐tower structure is interconnected with a long sky corridor bridge on the top floor. To reduce earthquake responses and member forces of towers bridge, passive control strategy friction pendulum tuned mass damper (FPTMD) was adopted. The as FPTMD. connection between designed flexible links, where bearings (FPBs) viscous dampers were installed. Elastoplastic time‐history analysis conducted by using Perform‐3D model to look into its seismic behavior under intensive excitation....
SUMMARY The peculiar building style and special structural system of the National Hall China Pavilion for Expo 2010 Shanghai is a long‐span large cantilevered steel–concrete hybrid structure with shape an inverted trapezoid in elevation local discontinuity floor slabs plan esthetic functional considerations. Because these characteristics, classified as irregular complex structure. To investigate seismic behavior structure, refined finite element model was established by using NosaCAD....