A5100456916- Cervical Cancer and HPV Research
- Liver Disease Diagnosis and Treatment
- Evolution and Paleontology Studies
- Paleontology and Evolutionary Biology
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Ichthyology and Marine Biology
- Virus-based gene therapy research
- Genetic diversity and population structure
- Diet, Metabolism, and Disease
- Respiratory viral infections research
- Lipid metabolism and disorders
- Cytomegalovirus and herpesvirus research
- Influenza Virus Research Studies
- interferon and immune responses
- Diet and metabolism studies
- Hepatitis B Virus Studies
- Cancer, Hypoxia, and Metabolism
- Inflammatory Bowel Disease
- Pediatric health and respiratory diseases
- MicroRNA in disease regulation
- Sepsis Diagnosis and Treatment
- Retinal Diseases and Treatments
- Genomics and Rare Diseases
- Autophagy in Disease and Therapy
Henan Provincial People's Hospital
2022-2025
Renmin Hospital of Wuhan University
2016-2025
Icahn School of Medicine at Mount Sinai
2024-2025
Wuhan University
2016-2025
Zhengzhou University
2025
Linyi University
2012-2024
China Medical University
2013-2024
Shandong Pingyi Tianyu Museum of Natural History
2018-2024
First Hospital of China Medical University
2011-2024
BGI Group (China)
2013-2024
Ornithuromorpha is the most inclusive clade containing extant birds but not Mesozoic Enantiornithes. The early evolutionary history of this avian has been advanced with recent discoveries from Cretaceous deposits, indicating that and Enantiornithes are two major groups in Mesozoic. Here we report on a new ornithuromorph bird, Archaeornithura meemannae gen. et sp. nov., second oldest avian-bearing deposits (130.7 Ma) world. taxon referable to Hongshanornithidae constitutes record...
Background Carotid atherosclerosis ( CA ) is a reflector of generalized that associated with systemic vascular disease. Data are limited on the epidemiology carotid lesions in large, nationally representative population sample. We aimed to evaluate prevalence detected by ultrasonography and related risk factors based national survey China. Methods Results A total 107 095 residents aged ≥40 years from China National Stroke Prevention Project underwent ultrasound examination. Participants...
High calorie intake is known to induce nonalcoholic fatty liver disease (NAFLD) by promoting chronic inflammation. However, the mechanisms are poorly understood. This study examined roles of ANGPTL8 in regulation NAFLD-associated fibrosis progression induced high fat diet (HFD)-mediated The concentration was measured serum samples from cancer and cirrhosis patients. knockout(KO) mice were used models (HFD, HFHC CCL4) followed pathological staining, western blot immunohistochemistry....
Changes in metabolic processes play a critical role the survival or death of cells subjected to various stresses. In present study, we have investigated effects ER (endoplasmic reticulum) stress on cellular metabolism. A major difficulty studying responses is that normally leads apoptosis and changes observed dying may be misleading. Therefore used IL-3 (interleukin 3)-dependent Bak-/-Bax-/- haemopoietic which do not die presence ER-stress-inducing drug tunicamycin. Tunicamycin-treated...
Cross talk between the angiotensin-converting enzyme (ACE)/angiotensin II (Ang II)/Ang type 1 (AT ) receptor axis and ACE2/Ang-(1–7)/Mas plays a role in pathogenesis of cardiovascular remodeling. Furthermore, possible stimulation Ang 2 by Ang-(1–7) has been highlighted as new pathway. Therefore, we examined possibility whether Ang-(1–7)/AT are involved inhibitory effects AT blockers on vascular Wild-type, Mas-knockout, knockout mice were used this study. Vascular injury was induced...
We aimed to develop and validate a nomogram combining bi-regional radiomics features from multimodal magnetic resonance imaging (MRI) clinicoradiological characteristics preoperatively predict microvascular invasion (MVI) of hepatocellular carcinoma (HCC).A total 267 HCC patients were divided into training (n=194) validation (n=73) cohorts according MRI data. Bi-regional extracted whole tumors peritumoral regions in MRI. The minimum redundancy maximum relevance (mRMR) algorithm was applied...
Dinosaur fossils possessing integumentary appendages of various morphologies, interpreted as feathers, have greatly enhanced our understanding the evolutionary link between birds and dinosaurs, well origins feathers avian flight. In extant birds, unique expression amino acid composition proteins in mature been shown to determine their biomechanical properties, such hardness, resilience, plasticity. Here, we provide molecular ultrastructural evidence that pennaceous Jurassic nonavian dinosaur...
Excessive lipid accumulation and high oxidative stress have become a serious health economic problem in the pig industry. Fatness characteristics are crucial production since they closely related to meat quality. The gut microbiome is well acknowledged as key element fat deposition. But link between microbiota pigs remains elusive. To examine whether there pigs’ microbiome, lipogenic properties, stress, we selected 5 high-fat low-fat from 60 250-day-old Jinhua present study collected colon...
Background: Sepsis remains a significant challenge in patients with major trauma the ICU. Early detection and treatment are crucial for improving outcomes reducing mortality rates. Nonetheless, clinical tools predicting sepsis among limited. This study aimed to develop validate an artificial intelligence (AI) platform risk of trauma. Methods: involved 961 patients, prospective analysis data from 244 at our hospital retrospective 717 extracted database United States. The constituted model...
A crop adapted for an herbivorous diet of seeds has previously been documented in the Early Cretaceous birds Sapeornis and Hongshanornis. Here we report on several specimens Yanornis that preserve a containing fish. One specimen preserves two whole fish oesophagus, indicating shared trophic specializations with Neornithes increased energetic demands flight – namely storing food later consumption when stomach is full. Whole also indicate despite their presence, teeth were not used to orally...
Abstract Body shape is a fundamental expression of organismal biology, but its quantitative reconstruction in fossil vertebrates rare. Due to the absence fossilized soft tissue evidence, functional consequences basal paravian body and implications for origins avians flight are not yet fully understood. Here we reconstruct outline Anchiornis based on high-definition images tissues revealed by laser-stimulated fluorescence. This confirms patagia-bearing arms, drumstick-shaped legs slender...
Objective: To investigate the risk factors and outcomes of macrosomia in China.Methods: This was a multicenter, retrospective cohort study conducted China. 178 709 singletons weighing ≥ 2500 g with gestational ages 37–44 weeks were included. We compared group (with birth weight (BW) 4000 g) nornosomic control (weighting 2500–3999 g).Results: The total prevalence 8.70%. strongest correlated maternal obesity diabetes mellitus (GDM). risks obstetric neonatal complications increased when infants...
Waste cooking oil (WCO) is a sustainable alternative to raw vegetable oils and fats for biodiesel production considering both environmental economic benefits. Raw glycerol from WCO-based (GWCO) difficult utilize via biological method, as multiple toxic impurities have inhibitory effects on microbial growth especially pure cultures. In this work, four consortia were selected activated sludge by 30 serial transfers under different conditions. The obtained exhibited lower diversity species...
Abstract Background Multiple murine models of nonalcoholic fatty liver disease/steatohepatitis (NAFLD/NASH) have been established by using obesogenic diets and/or chemical induction. MS-NASH mouse (formally FATZO) is a spontaneously developed dysmetabolic strain that can progress from hepatosteatosis to moderate fibrosis when fed western diet supplemented with 5% fructose (WDF). This study aimed use carbon tetrachloride (CCl 4 ) accelerate and aggravate progression NAFLD/NASH in mouse....
Cutaneous squamous cell carcinoma (cSCC) is the second most frequent of keratinocyte-derived malignancies with actinic keratosis (AK) as a precancerous lesion. To comprehensively delineate underlying mechanisms for whole progression from normal skin to AK invasive cSCC, we performed single-cell RNA sequencing (scRNA-seq) acquire transcriptomes 138,982 cells 13 samples six patients including AK, in situ (SCCIS), and their matched tissues, covering comprehensive clinical courses cSCC. We...
Familial chylomicronemia syndrome (FCS) and multifactorial (MCM), characterized by highly variable triglyceride levels with acute episodes of severe hypertriglyceridemia (HTG), are caused rare variants in genes associated the catabolism circulating lipoprotein triglycerides, mainly including LPL, APOC2, APOA5, GPIHBP1, LMF1. Among them, LMF1 gene only accounts for 1%. This study described a Chinese patient HTG carrying compound heterozygous nonsense variant p.W168X exon 3 missense p.R416Q 9...
China has implemented the "tiered medical services" policy since 2015, while there is a paucity of data evaluating current status chronic obstructive pulmonary disease (COPD) management under system. Characteristics and treatments from 11,905 COPD patients in 88 hospitals across different tiers were included analyzed. We assessed statistical significance differences by one way analysis variance (ANOVA) for continuous variables with chi-squared test categorical variables. Patients primary...