A5100383592- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- RNA Research and Splicing
- Autophagy in Disease and Therapy
- 3D Printing in Biomedical Research
- Thermochemical Biomass Conversion Processes
- Immune cells in cancer
- Additive Manufacturing and 3D Printing Technologies
- Genetic Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Osteoarthritis Treatment and Mechanisms
- Bone Metabolism and Diseases
- Renal and related cancers
- Mesenchymal stem cell research
- Immune Response and Inflammation
- Histone Deacetylase Inhibitors Research
- Tissue Engineering and Regenerative Medicine
- Pesticide Residue Analysis and Safety
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Advanced Nanomaterials in Catalysis
- DNA and Nucleic Acid Chemistry
Zhujiang Hospital
2025
Southern Medical University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
Jiangsu University
2017-2025
Harbin Medical University
2014-2025
Peking Union Medical College Hospital
2019-2025
Second Affiliated Hospital of Dalian Medical University
2025
Dalian Medical University
2023-2025
University of Wisconsin–Madison
2024
The Wallace H. Coulter Department of Biomedical Engineering
2017-2024
Superabsorbent polymers are new functional polymeric materials that can absorb and retain liquids thousands of times their masses. This paper reviews the synthesis modification methods different superabsorbent polymers, summarizes processing for forms organizes applications research progress in industrial, agricultural, biomedical industries. Synthetic like polyacrylic acid, polyacrylamide, polyacrylonitrile, polyvinyl alcohol exhibit superior water absorption properties compared to natural...
Deregulated expression of chemokines in tumor microenvironment contributes to metastasis by targeting distinct cells. Epithelial-derived neutrophil-activating peptide-78 (ENA78/CXCL5) is upregulated many cancers and involved progression. The role underlying mechanism CXCL5 gastric cancer (GC) remain unclear. In this study, we reported that the was elevated tissues positively associated with lymphatic differentiation. Stimulation recombinant human (rhCXCL5) induced epithelial-mesenchymal...
Exosomes from human umbilical cord mesenchymal stem cells (hucMSC-Ex) have been suggested as novel nanomaterials for regenerative medicine. Here we explored the roles of hucMSC-Ex through regulating Yes-associated protein (YAP) in renal injury repair by using rat unilateral ureteral obstruction (UUO) models. Our study identified mechanical stress induced YAP nucleus expression and stimulated collagen deposition interstitial fibrosis kidney. Then, infusion with promoted nuclear cytoplasmic...
The development of lethal cancer metastasis depends on the dynamic interactions between cells and tumor microenvironment, both which are embedded in extracellular matrix (ECM). acquisition resistance to detachment-induced apoptosis, also known as anoikis, is a critical step metastatic cascade. Thus, more in-depth systematic analysis needed identify key drivers anoikis resistance.Genome-wide CRISPR/Cas9 knockout screen was used using SKOV3 cell line found protein-L-isoaspartate (D-aspartate)...
Lung cancer is the leading cause of cancer-related deaths worldwide. Long non-coding RNAs (lncRNAs) have emerged as key regulators development and progression, promising biomarkers for diagnosis prognosis cancer. In this study, we identified a new lncRNA (LINC02159) that was upregulated in tumor tissues serum non-small cell lung (NSCLC) patients. We demonstrated knockdown LINC02159 inhibited NSCLC proliferation, migration, invasion, but induced apoptosis cycle arrest vitro retarded growth...
Anomanolide C (AC), a natural withanolide isolated from Tubocapsicum anomalum, has been reported to have exhibits remarkable anti-tumour activities in several types of human cancers, particularly triple-negative breast cancer (TNBC).However, its intricate mechanisms still remain need be clarified.Here, we evaluated whether AC could inhibit cell proliferation and the role ferroptosis induction autophagy activation.Subsequently, anti-migration potential was found via autophagy-dependent...
Abstract Renal interstitial fibrosis (RIF) is a fundamental pathological feature of chronic kidney disease (CKD). However, toxicity and poor renal enrichment inhibitors limit their further applications. In this study, platform for CKD therapy developed using superparamagnetic iron oxide nanoparticles (SPION) decorated mesenchymal stem cells derived extracellular vesicles with carboxyl terminus Hsc70-interacting protein (CHIP) high expression (SPION-EVs) to achieve higher renal-targeting...
Gastric cancer (GC) is the third leading cause of cancer-related death worldwide. Sensitive and accurate biomarkers can greatly aid in early diagnosis favorable prognosis. Neutrophils are most abundant immune cells human circulation play a critical role tumor progression. Neutrophil-derived exosomes (Neu-Exo) contain bioactive molecules critically involved disease
Myocardial infarction (MI) is one of the leading causes death. This attributed to dramatic changes in myocardial microenvironment post-MI. Therefore, effective intervention early stages MI significant for inhibiting its progression and improving cardiac function. Herein, an injectable composite hydrogel scaffold (Gel-pBP@Mg) was developed by integrating magnesium (Mg)-modified black phosphorus nanosheets (pBP@Mg) into a reactive oxygen species-responsive (Gel). loose porous Gel provides...
Studies have demonstrated low expression of miR-145 associated with cell proliferation and migration in a wide variety tumors. Here, we studied the relation to occurrence development breast cancer. Total RNA from cancer tissue corresponding adjacent normal was extracted used detect by quantitative real-time polymerase chain reaction (qRT-PCR). We also transfected cells hsa-miR-145 mimics, inhibitor, mimics negative control (mimics NC) or inhibitor (inhibitor NC). Cell analyzed colony...
We aimed to develop and validate a nomogram combining bi-regional radiomics features from multimodal magnetic resonance imaging (MRI) clinicoradiological characteristics preoperatively predict microvascular invasion (MVI) of hepatocellular carcinoma (HCC).A total 267 HCC patients were divided into training (n=194) validation (n=73) cohorts according MRI data. Bi-regional extracted whole tumors peritumoral regions in MRI. The minimum redundancy maximum relevance (mRMR) algorithm was applied...
Diabetic cutaneous wounds are one of the complications diabetes mellitus (DM) and difficult to cure at present. Autologous dermal fibroblasts (DFs) have shown great promise in skin regeneration repair. However, whether exosomes derived from autologous (DF-Ex) can be used accelerate diabetic wound healing is unclear. In this study, human umbilical vein endothelial cells (HUVECs) were treated with high glucose. We found that DF-Ex could reverse damage produced by glucose HUVECs vitro. A...
Salt ions play an important role in the quality structure of food and sensory properties. This study aims to investigate effects different concentrations calcium chloride (0–0.012 mol/L) on gel properties interactions heat-induced Mesona chinensis polysaccharide (MCP)-whey protein isolate (WPI) mixed gels. It was found that apparent viscosity decreases gradually with increase ion concentration, especially when concentration reaches 0.012 mol/L, is lowest. The water holding capacity decreased...
Abstract Breast cancer is still one of the most common malignancies worldwide and remains a major clinical challenge. We previously reported that anthelmintic drug flubendazole induced autophagy apoptosis via upregulation eva-1 homolog A (EVA1A) in triple-negative breast (TNBC) was repurposed as novel anti-tumor agent. However, detailed underlying mechanisms remain unclear need further investigation. Here, we found impairs permeability mitochondrial outer membrane function cancer. Meanwhile,...
Abstract Background As a leading cause of vision decline and severe blindness in adults, diabetic retinopathy (DR) is characterized by the aggravation retinal oxidative stress apoptosis early stage. Emerging studies reveal that mesenchymal stem cells-derived small extracellular vesicles (MSC-sEV) treatment represents promising cell-free approach to alleviate ocular disorders. However, repairing effects MSC-sEV DR remain largely unclear. This study aimed at exploring role underlying mechanism...
Atherosclerosis preferentially occurs in arterial regions exposed to disturbed blood flow ( d-flow ), while stable s-flow ) are protected. The proatherogenic and atheroprotective effects of mediated part by the global changes endothelial cell (EC) gene expression, which regulates dysfunction, inflammation, atherosclerosis. Previously, we identified kallikrein-related peptidase 10 Klk10 , a secreted serine protease) as flow-sensitive mouse ECs, but its role biology atherosclerosis was...
Endocytosis is a major bottleneck toward cytosolic delivery of nucleic acids, as the vast majority acid drugs remain trapped within endosomes. Current trends to overcome endosomal entrapment and subsequent degradation provide varied success; however, active agents such cell-penetrating peptides have emerged prominent strategy improve delivery. Yet, these membrane-active poor selectivity for membranes, leading toxicity. A hallmark endosomes their acidic environment, which aids in foreign...
Abstract Metal halide perovskites have emerged as versatile photocatalysts to convert solar energy for chemical processes. Perovskite photocatalyzed polymerization draws special attention due its straightforward synthesis process and the ability create advanced perovskite‐polymer nanocomposites. Herein, this work employs Cs 3 Sb 2 Br 9 perovskite nanoparticles (NPs) a lead‐free photocatalyst light‐controlled atom transfer radical (ATRP). NPs exhibit high reduction potential interact with...