A5088642273- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Mesenchymal stem cell research
- Circular RNAs in diseases
- Esophageal Cancer Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Wound Healing and Treatments
- Lung Cancer Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Ion Channels and Receptors
- Colorectal and Anal Carcinomas
- Spinal Cord Injury Research
- Hippo pathway signaling and YAP/TAZ
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Cancer Cells and Metastasis
- Head and Neck Cancer Studies
- Tissue Engineering and Regenerative Medicine
- Acute Kidney Injury Research
- Maternal Mental Health During Pregnancy and Postpartum
- Galectins and Cancer Biology
Anhui Medical University
2023-2025
Jiangsu University
2017-2025
Affiliated Hospital of Hangzhou Normal University
2022-2025
Hangzhou Normal University
2025
University of Science and Technology of China
2022-2024
Jining First People's Hospital
2017-2024
Huazhong University of Science and Technology
2014-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Anhui Provincial Children's Hospital
2022
Cold Spring Harbor Laboratory
2022
Exosomes are nanosized extracellular vesicles (EVs) that show great promise in tissue regeneration and injury repair as mesenchymal stem cell (MSC). MSC has been shown to alleviate diabetes mellitus (DM) both animal models clinical trials. In this study, we aimed investigate whether exosomes from human umbilical cord (hucMSC-ex) have a therapeutic effect on type 2 DM (T2DM). We established rat model of T2DM using high-fat diet streptozotocin (STZ). found the intravenous injection hucMSC-ex...
mRNA migration through plasmodesmata In plants, certain transcription factors are produced in one cell but transported, sometimes as messenger RNA (mRNA), plasmodesmata, channels between neighboring plant cells, where they act. This system helps to manage stem development. Kitagawa et al . now identify part of the machinery that manages this cell-to-cell transport. Transport encoding KNOTTED1 homeobox factor depends on Ribosomal RNA-Processing Protein 44 (AtRRP44A), which is a subunit exosome. —PJH
Diabetic wounds exhibit delayed and incomplete healing, usually due to vascular nerve damage. Dysregulation of cellular Ca2+ homeostasis has recently been shown be closely related insulin resistance type 2 diabetes mellitus. However, the involvement this dysregulation in diabetic wound complications remains unknown. In study, we found calcium patients with ulcers via tissue protein profiling. High glucose glucometabolic toxicant stimulation considerably impaired function TRPC6, a pore...
Human umbilical cord mesenchymal stem cell-derived small extracellular vesicles (hucMSC-sEV) have recently garnered attention as a potential therapeutic approach for kidney diseases with anti-inflammatory effects. Infiltrated macrophages play an important role in facilitating tissue regeneration. However, the intricate regulatory effects of hucMSC-sEV on during cisplatin-induced acute injury (AKI) remain unknown. In this study, we uncovered that exhibited potent anti-inflammation and...
Abstract The antitumor effect of prostaglandin D2 (PGD2) on gastric cancer (GC) has been known for decades. However, the mechanism PGD2's control GC growth is unclear. Cancer stem cells (CSCs) are implicated in tumor neovascularization, invasiveness, and therapeutic resistance. Herein, we discovered that signaling between PGD2 its receptor (PTGDR2) ability to restrict self-renewal vitro suppress metastasis vivo. To obtain these findings, first determined synthase (L-PTGDS) PTGDR2 expression...
Exosomes derived from human umbilical cord mesenchymal stem cells (hucMSC-ex) are nano-sized membrane-bound vesicles that have been reported to facilitate skin regeneration and repair. However, the roles played by hucMSC-ex in ultraviolet (UV) radiation-induced photodamage underlying mechanisms remain unknown. To investigate functions of a rat model acute photodamage, immunofluorescence immunohistochemical staining, quantitative real-time-polymerase chain reaction (qRT-PCR), western blot,...
Diabetic cutaneous wounds are one of the complications diabetes mellitus (DM) and difficult to cure at present. Autologous dermal fibroblasts (DFs) have shown great promise in skin regeneration repair. However, whether exosomes derived from autologous (DF-Ex) can be used accelerate diabetic wound healing is unclear. In this study, human umbilical vein endothelial cells (HUVECs) were treated with high glucose. We found that DF-Ex could reverse damage produced by glucose HUVECs vitro. A...
Circular RNAs (circRNAs) are considered as a new regulatory factor in growth, metastasis and therapeutic resistance of human cancers. But the clinical significance underlying mechanism circular RNA ITCH (circ-ITCH) gastric cancer (GC) remain unknown. In present study, we found that circ-ITCH was down-regulated GC cell lines, tissues their serum-derived exosomes. The level related to invasion depth. Functional assays showed overexpression inhibited proliferation, migration, epithelial...
To explore the relationship of a new PET image parameter, (18)F-fluorodeoxyglucose ((18)F-FDG) uptake heterogeneity assessed by texture analysis, with maximum standardized value (SUV(max)) and tumor TNM staging.Forty consecutive patients esophageal squamous cell carcinoma were enrolled. All underwent whole-body preoperative (18)F-FDG PET/CT. Heterogeneity intratumoral was on basis textural features (entropy energy) three-dimensional images using MATLAB software. The correlations between...
Abstract Human umbilical cord-derived mesenchymal stem cells (hucMSCs) are a promising tool for damaged tissues repair, especially the kidney. However, their efficacy requires improvement. In order to optimize clinical utility of hucMSCs, we adopted strategy treating hucMSCs with 20 μmol/L resveratrol (Res-hucMSCs), applying it in cisplatin-induced acute kidney injury model. Interestingly, found that Res-hucMSCs exhibited more efficient repairing effect than did hucMSCs. Resveratrol-promoted...
Human umbilical cord mesenchymal stem cells-derived small extracellular vesicles (hucMSC-sEVs) have been demonstrated as a therapeutic agent to prevent and treat cisplatin-induced acute kidney injury (AKI). However, hucMSC-sEVs still face many problems challenges in the repair treatment of tissue injury, including short circulation time, insufficient targeting, low efficacy. Therefore, we constructed engineered hybrid fused with nanovesicles derived from human neutrophil membranes...
Spinal cord injury (SCI) is a serious disease of the central nervous system that associated with poor prognosis; furthermore, existing clinical treatments cannot restore nerve function in an effective manner. Inflammatory responses and increased production reactive oxygen species (ROS) microenvironment lesion are major obstacles inhibit recovery SCI. Small extracellular vesicles (sEVs), derived from mesenchymal stem cells, suitable options for cell-free therapy have been shown to exert...
PURPOSE This multicenter, randomized, phase III clinical trial (Northern Radiation Oncology Group of China-002) focused on patients with oligo-organ metastatic non–small cell lung cancer (NSCLC) who have epidermal growth factor receptor ( EGFR ) mutations. We aimed to investigate whether first-line concurrent thoracic radiotherapy (TRT) and EGFR-tyrosine kinase inhibitors (TKIs), compared TKIs alone, could achieve better survival. MATERIALS AND METHODS The in the TKI plus TRT group received...
Abstract Stem cells (SCs) have been used therapeutically for decades, yet their applications are limited by factors such as the risk of immune rejection and potential tumorigenicity. Extracellular vesicles (EVs), a key paracrine component stem cell potency, overcome drawbacks cell-free therapeutic agent play an important role in treating various diseases. However, EVs derived from two-dimensional (2D) planar culture SCs low yield face challenges large-scale production, which hinders clinical...
School-based universal depression screening (SBUDS) is an effective method for early identification of depression. As parents are the primary decision-makers their children's acceptance healthcare services, this study aims to examine rural and urban parental SBUDS. The assessed SBUDS children its association with self-reported perception (i.e., knowledge depression, self-efficacy identify child stigma) belief regarding benefits risks analysis included 13,480 at least one in grades 4–12 from...