A5021185518- Esophageal Cancer Research and Treatment
- Cancer-related gene regulation
- Reproductive Biology and Fertility
- Pancreatic and Hepatic Oncology Research
- Reproductive Health and Technologies
- Assisted Reproductive Technology and Twin Pregnancy
- RNA modifications and cancer
- MicroRNA in disease regulation
- Lung Cancer Research Studies
- Reproductive System and Pregnancy
- Ovarian function and disorders
- Immunotherapy and Immune Responses
- Epigenetics and DNA Methylation
- Digital Platforms and Economics
- Endometriosis Research and Treatment
- TGF-β signaling in diseases
- Structural mechanics and materials
- Endoplasmic Reticulum Stress and Disease
- Hippo pathway signaling and YAP/TAZ
- Business Strategy and Innovation
- Angiogenesis and VEGF in Cancer
- Effects of Radiation Exposure
- Inflammatory mediators and NSAID effects
- Structural Load-Bearing Analysis
- Lung Cancer Treatments and Mutations
Sun Yat-sen University
2025
Sun Yat-sen University Cancer Center
2025
Gansu Provincial Hospital
2019-2025
Weihai Science and Technology Bureau
2024
Weifang Medical University
2023
Affiliated Hospital of Jining Medical University
2020-2023
Jining Medical University
2023
Weifang People's Hospital
2023
Central South University
2023
Shaanxi Provincial People's Hospital
2019-2021
Objective: To investigate whether obstetric complications and perinatal outcomes after frozen embryo transfer (FET) in programming cycles differ from that natural cycles. Methods: we conducted a retrospective cohort study collecting total of 14373 singletons born at the center for reproductive medicine affiliated to Shandong university, September 2013 2018. Women were divided into two groups according regimens endometrium preparation: either (n=10211) or (n=4162). The primary incidence...
PURPOSE This multicenter, randomized, phase III clinical trial (Northern Radiation Oncology Group of China-002) focused on patients with oligo-organ metastatic non–small cell lung cancer (NSCLC) who have epidermal growth factor receptor ( EGFR ) mutations. We aimed to investigate whether first-line concurrent thoracic radiotherapy (TRT) and EGFR-tyrosine kinase inhibitors (TKIs), compared TKIs alone, could achieve better survival. MATERIALS AND METHODS The in the TKI plus TRT group received...
SUMMARY Radiotherapy is a useful component of treatment strategies for esophageal cancer. The role autophagy in response to ionizing radiation was investigated human squamous carcinoma cells. Cell viability and clonogenic survival assay were used evaluate the radiosensitivity inhibitor (3-MA) on percentage apoptotic cells cell cycle analysis assessed by flow cytometry; DAPI staining detect expression beclin-1 LC3 measured using Western blot. ultrastructural under electron microscope. 6 Gy...
The role of prophylactic cranial irradiation (PCI) in patients with limited-stage small-cell lung cancer (LS-SCLC) remains controversial the era magnetic resonance imaging (MRI). present study aimed to evaluate effectiveness PCI treatment LS-SCLC MRI. PubMed, EMBASE and Cochrane Library databases were searched from time database creation until May 24, 2023, identify clinical studies that evaluated MRI era. references obtained also reviewed not discovered initial search. All screened...
The potential survival benefits of adding radiotherapy to systemic therapy for esophageal cancer patients with oligometastases are unknown.In this retrospective analysis, stage IV (according the American Joint Committee on Cancer Seventh edition staging system) ≤3 metastases who underwent chemotherapy cisplatin/paclitaxel between 2012 and 2015 were identified. Patients received (CT) alone vs. concurrent chemoradiotherapy (CCRT) all metastases.Of 461 patients, 97% had squamous cell cancer....
To determine the cutoff values of HOMA-IR for predicting clinical pregnancy rate in normal weight patients during their first IVF.The data was retrospectively analyzed from 329 normal-weight women aged 21-40 years with BMI <25 kg/m2 who received IVF-ET period December 2018 to June 2019.We assessed associations between and rates IVF or without PCOS according different ranges.In non PCOS,clinical significantly decreased at ranging 2.2 3.15 (OR, 0.188, 95% CI, 0.084-0.42; p < .05) those >3.15...
Cancer vaccines mostly aim to induce cytotoxic T lymphocytes (CTLs) against tumors. An appropriate adjuvant is of fundamental importance for inducing cellular immune response. Since the antigen in particulate form substantially more immunogenic than soluble antigen, it beneficial interact with antigen-presenting cells membrane robust CD8+ cell activation following vaccination. Based on previous research, we designed an formulation by combining Astragalus saponins, cholesterol, and liposome...
Definitive chemoradiation is a curative treatment option for patients with locoregional esophageal squamous cell carcinoma (ESCC) who are not suitable surgical resection, but many tend to develop local recurrence. The purpose of the study was investigate factors affecting recurrence tumor. Seventy-two stage II–III thoracic ESCC received definitive concurrent (CRT) and completely responded were enrolled into this study. case 49 recurred locally within 24 months after CRT 23 did have...
Tumor growth and metastasis are closely related to angiogenesis. Basic fibroblast factor(bFGF) is an angiogenic factor, up-regulated expression of bFGF plays a crucial role in the development melanoma. Therefore, this study, we sought achieve antitumor activity by immunity targeting which would inhibit tumor angiogenesis simultaneously induce specific cytotoxic T lymphocytes kill melanoma cells. A human protein was used as exogenous antigen, coupled with saponin-liposome adjuvant formulation...
Post-resistance progress in paclitaxel (PTX) treatment remains a major challenge tumor treatment. A high dose of PTX was used for cell lines to analyze the changes molecular expression. The miR-378d sharply reduced surviving cells, but role Esophageal squamous carcinoma (ESCC) remained unclear.We analyzed relationship between expression and clinicopathological features ESCC. We constructed silent study phenotypes mechanisms.The associated with good prognosis patients inhibition promoted...
Bone morphogenetic protein (BMP) expression has been observed in the uterus previous studies. However, influence of BMP7 on blastocyst implantation remains unclear. Blastocysts first act luminal endometrial epithelial cells during implantation. The purpose present study was to explore cells. A pregnancy animal model, and mouse human were used study. Transient knockdown, immunofluorescence assay, vitro embryo implantation, silencing, reverse transcription-quantitative polymerase chain...
Abstract Objective Definitive chemoradiotherapy (dCRT) is one of the standard treatments for esophageal squamous cell carcinoma (ESCC), but local recurrence main cause treatment failure. The changes in apoptosis and autophagy recurrent tumors patients with ESCC following dCRT have been poorly estimated. Thus, this study aimed to investigate expressions key regulators matched paired samples primary ESCC. Methods medical records locally advanced who developed after were reviewed, expression...
Studies have shown that stress such as hypoxia, chemotherapy, radiotherapy can lead to polyploidization of tumor cells, which play an important role in heterogeneity and malignant phenotype. Paclitaxel (PTX) treatment promoted polyploid cancer cells (PCCs) formation, miR-378d is sharply reduced PCCs esophageal squamous cell carcinomas (ESCC) but participation formation the impact on biological behavior ESCC remains unclear. We analyzed vivo vitro, related proteins regulated by miR-378d....
Objective To investigate the clinical effect of human cleavage embryos cryopreservation by vitrification.Methods With patients' consent,the remaining which met standards after third day transplantation were vitrificated.If fresh cycle pregnancy failed,according to conditions patients,the thawred.The survival rate and recovery thawing observed.Results Among 207 embryo vitrificated from 84 cycles,198 survived,the was 95.7％ ; 187 completely complete 90.3 ％ 41 implantated,the implantation 19.8％...
<title>Abstract</title> Lung cancer is one of the malignant tumors with highest morbidity and fatality rates worldwide. The overall survival (OS) lung adenocarcinoma (LUAD) poor. Cuproptosis a copper-triggered modality mitochondrial cell death, its contribution to LUAD unknown. clinical implication immunological function cuproptosis-related genes (CRGs) in has yet be established. TCGA, HPA, GEPIA, Kaplan-Meier, TIMER CancerSEA database were used explore prognostic value biological CRGs LUAD....
The important character of the applied moment with a fixed line direction as implied in deriving governing differential equations LTB for elastic beams, however, is not represented stating boundary conditions based on conventional energy approaches. This paper sets out to consider derived by potentials order identify ignored second-order moments that need be added maintaining initial during LTB. By taking into account non-zero work done these modifying original potentials, nonconservative...
Abstract Background: Chemoresistance is an important cause of malignant progression esophageal squamous cell carcinomas (ESCCs). miR-378d sharply reduced in paclitaxel (PTX)-resistance cancer cells by gene-expression profile analysis (RNA-Seq), but the mechanism miR-378d-mediated tumor unclear. Patients and methods: Herein, we detected expression 596 ESCC patients situ hybridization. Results showed that low was associated with poor prognosis patients, absence enhanced carcinogenesis...
Summary Intact human sperm DNA is an essential prerequisite for successful fertilization and embryo development. Abnormal fragmentation a independent factor male infertility. The objective of this study was to investigate the effects Peijingsu, health product, on integrity sperm. Peijingsu administered 15 days 22 patients who had abnormal index (DFI). DFIs before after treatment were compared analyzed using paired t -test. decreased significantly ( P = 0.0008) treatment, therefore it...