A5100440299- Cancer, Hypoxia, and Metabolism
- Hippo pathway signaling and YAP/TAZ
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Genetic Associations and Epidemiology
- Lipid metabolism and biosynthesis
- Cancer-related gene regulation
- Amino Acid Enzymes and Metabolism
- Cancer Research and Treatments
- MicroRNA in disease regulation
- Peroxisome Proliferator-Activated Receptors
- Fibroblast Growth Factor Research
- Wnt/β-catenin signaling in development and cancer
- Zebrafish Biomedical Research Applications
- Angiogenesis and VEGF in Cancer
- Cancer-related Molecular Pathways
- Cancer Genomics and Diagnostics
- ATP Synthase and ATPases Research
- Sarcoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Metabolism, Diabetes, and Cancer
- Endoplasmic Reticulum Stress and Disease
- RNA Research and Splicing
- Prostate Cancer Treatment and Research
First Affiliated Hospital of Gannan Medical University
2025
Huazhong University of Science and Technology
2013-2024
Union Hospital
2008-2024
University of Gothenburg
2023
Wuhan University
2015-2023
Binzhou University
2023
Binzhou Medical University
2023
First Affiliated Hospital of Xi'an Jiaotong University
2017-2023
Ministry of Education of the People's Republic of China
2012-2023
Guangzhou Medical University
2022
Objective Increased de novo fatty acid (FA) synthesis and cholesterol biosynthesis have been independently described in many tumour types, including hepatocellular carcinoma (HCC). Design We investigated the functional contribution of synthase (Fasn)-mediated FA a murine HCC model induced by loss Pten overexpression c-Met (sgPten/c-Met) using liver-specific Fasn knockout mice. Expression arrays lipidomic analysis were performed to characterise global gene expression lipid profiles,...
Abstract Activation of the AKT/mTOR cascade and overexpression c-Met have been implicated in development human hepatocellular carcinoma (HCC). To elucidate functional crosstalk between two pathways, we generated a model characterized by combined expression activated AKT mouse liver. Co-expression triggered rapid liver tumor mice required to be euthanized within 8 weeks after hydrodynamic injection. At molecular level, tumors induced AKT/c-Met display activation Ras/MAPK cascades as well...
Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the most prevalent types of primary liver cancer. These malignancies have limited treatment options, resulting in poor patient outcomes. Metabolism reprogramming, including increased de novo lipogenesis, is one hallmarks Fatty acid synthase (FASN) catalyzes synthesis long‐chain fatty acids from acetyl‐coenzyme A malonyl‐coenzyme A. Increased FASN expression has been reported multiple tumor types, inhibition shown to...
Abstract The development of chemoresistance remains a major challenge that accounts for colorectal cancer (CRC) lethality. Dichloroacetate (DCA) was originally used as metabolic regulator in the treatment diseases; here, DCA assayed to identify mechanisms underlying CRC. We found markedly enhanced chemosensitivity CRC cells fluorouracil (5-FU), and reduced colony formation due high levels apoptosis. Using microarray assay, we noted miR-149-3p involved CRC, which modulated by wild-type p53...
It has been demonstrated that glutamine metabolism become the main energy and building blocks supply for growth viability of a potentially large subset malignant tumors. The often depends upon mitochondrial glutaminase (GLS) activity, which converts to glutamate serves as significant role bioenergetic processes. Thus, recently, GLS key target small molecule therapeutic intervention. Numerous medicinal chemistry studies are currently aimed at design novel potent inhibitors GLS, however, date,...
Specification of arteries and veins is a key process for establishing functional vasculature during embryogenesis involves distinctly different signaling mechanisms. Vascular endothelial growth factor-A (VEGFA) required differentiation arteries; however, the upstream angiogenic factor vein specification unknown. Klippel–Trenaunay syndrome (KTS) congenital vascular disease associated with capillary venous malformations (VMs), but not arterial defects. We have previously reported that...
Abstract Background & Aims Although it is well established that fatty acids ( FA ) are indispensable for the proliferation and survival of cancer cells in hepatocellular carcinoma HCC ), inhibition Fatty Acid Synthase FASN cannot completely repress cell growth culture. Thus, we hypothesized uptake exogenous by might play an important role development progression . Lipoprotein lipase LPL enzyme catalyses hydrolysis triglycerides into free FFA increases cellular Methods We used...
Although significant progress has been made in the diagnosis and treatment of gastric cancer, overall survival rate disease remains unchanged at approximately 20%‐25%. Thus, there is an urgent need for a better understanding molecular biology aspects hope discovering novel strategies. Recent years have witnessed decisive roles aberrant cancer cell metabolism maintenance malignant hallmarks cancers, regarded as target cancer. CDK 2, cycle‐dependent kinase that usually regulates cycle...
Background Peripheral arterial disease (PAD) is a common accounting for about 12% of the adult population, and causes significant morbidity mortality. Therapeutic angiogenesis using angiogenic factors has been considered to be potential treatment option PAD patients. In this study, we assessed new factor AGGF1 therapeutic in critical limb ischemia model mice PAD. Methods Results We generated unilateral hindlimb by ligation right iliac artery femoral artery. Ischemic with intrasmuscular...
The loss of contact inhibition is a hallmark cancer cells. Hippo pathway has recently been shown to be an important regulator inhibition, and the cell apical polarity determinant protein CRB3 suggested involved in signalling. However, whether regulates mammary cells remains unclear, underlying mechanisms have not elucidated. As present study, decreases proliferation, promotes apoptosis, enhances formation tight adherens junctions. Furthermore, we report for first time that acts as upstream...
The inhibition of glutaminase 1 (GLS1) represents a potential treatment malignant tumors. Structural analysis led to the design novel series macrocyclic GLS1 allosteric inhibitors. Through extensive structure–activity relationship studies, promising candidate molecule 13b (LL202) was identified with robust inhibitory activity (IC50 = 6 nM) and high binding affinity (SPR, Kd 24 nM; ITC, 37 nM). X-ray crystal structure 13b–GLS1 complex resolved, revealing unique mode providing structural...
// Jie Luo 1, 2, 3, 4, 5 , Soo Ok Lee Yun Cui Rachel Yang Lei Li 5, 6 Chawnshang Chang 7 1 Department of Pathology, University Rochester, NY 14642, USA 2 Urology, 3 Radiation Oncology, 4 Biology, The Wilmot Cancer Center, Sex Hormone Research First Affiliated Hospital, Xian Jiaotong University, 710061, China Medical and Taichung, 404, Taiwan Correspondence to: Chang, e-mail: chang@urmc.rochester.edu Li, lilydr@163.com Keywords: CCL5, bone marrow mesenchymal stem cells, HIF2α, androgen...
Abstract The serine/threonine kinase STK33 has been implicated in cancer cell proliferation. Here, we provide evidence of a critical role for the pathogenesis and metastatic progression pancreatic ductal adenocarcinoma (PDAC). expression PDAC was regulated by hypoxia-inducible transcription factor HIF1α. In human specimens, overexpressed associated with poor prognosis. Enforced promoted proliferation, migration, invasion, tumor growth, whereas depletion exerted opposing effects. Mechanistic...