A5016161571- Hepatocellular Carcinoma Treatment and Prognosis
- Diabetes Treatment and Management
- Liver Disease Diagnosis and Treatment
- Pharmacology and Obesity Treatment
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Pediatric health and respiratory diseases
- Pancreatic and Hepatic Oncology Research
- Asthma and respiratory diseases
- Ferroptosis and cancer prognosis
- T-cell and B-cell Immunology
- Gastric Cancer Management and Outcomes
- Metabolism, Diabetes, and Cancer
- Pancreatitis Pathology and Treatment
- Lipid metabolism and disorders
- PI3K/AKT/mTOR signaling in cancer
- Visual Attention and Saliency Detection
- Plant Ecology and Soil Science
- Economic and Financial Impacts of Cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Extracellular vesicles in disease
- Pharmaceutical studies and practices
- Health Systems, Economic Evaluations, Quality of Life
- Technology and Data Analysis
University of Macau
2018-2025
Beijing Children’s Hospital
2024
University of Shanghai for Science and Technology
2024
Capital Medical University
2024
Center for Children
2024
Macau University of Science and Technology
2024
Quality Research
2021
Wuhan University of Science and Technology
2020
Shanghai Ninth People's Hospital
2019
Shanghai Jiao Tong University
2019
Abstract The development of chemoresistance remains a major challenge that accounts for colorectal cancer (CRC) lethality. Dichloroacetate (DCA) was originally used as metabolic regulator in the treatment diseases; here, DCA assayed to identify mechanisms underlying CRC. We found markedly enhanced chemosensitivity CRC cells fluorouracil (5-FU), and reduced colony formation due high levels apoptosis. Using microarray assay, we noted miR-149-3p involved CRC, which modulated by wild-type p53...
Background: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality globally. Recent advancements in targeted therapies have improved outcomes for advanced HCC, yet therapeutic options remain limited. The CARES-310 trial demonstrated that camrelizumab plus rivoceranib significantly improves survival compared to sorafenib HCC. Objectives: This study aimed evaluate cost-effectiveness as a first-line treatment unresectable HCC from Chinese health system...
This study aimed to evaluate the long- and short-term cost-effectiveness of once-weekly semaglutide versus dulaglutide for treating patients with type 2 diabetes uncontrolled metformin after renewal China's national reimbursement drug list. analysis was conducted using Institute Health Economics Diabetes Cohort Model (IHE-DCM) long-term health economic outcomes 0.5 mg, 1.0 1.5 mg. It performed from perspective Chinese healthcare systems over a 40-year time horizon, an annual discount rate...
Chemoresistance is responsible for most colorectal cancer (CRC) related deaths. In this study, we found that dichloroacetate (DCA), a pyruvate dehydrogenase kinase (PDK) inhibitor, can be used as sensitizer oxaliplatin (L-OHP) chemoresistant CRC cells. The aim of study was to explore the ability DCA overcome L-OHP resistance in cells and identify underlying molecular mechanisms. We sensitizes L-OHP-induced cytotoxic effects by inhibiting clone formation capacity promoting cell apoptosis. A...
Thalidomide (THD), a synthetic derivative of glutamic acid, was initially used as sedative and antiemetic until the 1960s, when it found to cause devastating teratogenic effects. However, subsequent studies have clearly demonstrated anti-inflammatory, anti-angiogenic, immunomodulatory properties thalidomide, thus providing rationale for its current use in treatment various autoimmune diseases cancers. Our group that thalidomide can suppress regulatory T cells (Tregs), minor subset CD4+...
Objective To describe the proportion and clinical characteristics of hospitalized children with acute asthma attacks complicated by respiratory failure to analyze risk factors. Methods This retrospective study analyzed hospital admissions adolescents between January 2016 December 2021. Inclusion criteria were used identify eligible cases, demographic information disease collected. Patients categorized into group other based on result artery blood gas analysis. Multivariate logistic...
The objective of the current study was to assess long-term cost-effectiveness once-weekly semaglutide 0.5 mg and 1.0 versus dulaglutide 1.5 for treatment patients with type 2 diabetes uncontrolled on metformin in Chinese setting. Swedish Institute Health Economics Diabetes Cohort Model (IHE-DCM) used evaluate health economic outcomes dulaglutide. Analysis conducted from perspective healthcare systems over a time horizon 40 years. Data baseline cohort characteristics effects were sourced...
Objective To describe clinical characteristics of hospitalized children with acute asthma attacks complicated mucus plugs and to investigate the factors associated in children. Methods This retrospective study analyzed adolescents from January 2016 December 2021. The demographic information were collected. Subjects categorized into plug group control based on bronchoalveolar lavage results. Logistic regression analyses utilized assess relative plugs. All data using SPSS 22.0. Results...
<title>Abstract</title> <bold>Background:</bold> The process of asthma, after its onset, is featured by periods persistence, relapse and remission. This follow-up study explored factors affecting the persistence asthma in children aged 0-18 years at Beijing Children's Hospital. <bold>Methods:</bold>Children hospitalized Hospital from 2019 to 2021 due acute attacks were selected as objects. A questionnaire was used collect management discharge. defined having ≥1 within nearly one year,...
Background The objective of this study was to systematically analyse methodological and structural assumptions utilised in model-based health economic evaluations systemic advanced hepatocellular carcinoma (HCC) therapies, discuss the existing challenges, develop recommendations for future models HCC. Methods We performed literature searches using five databases (Embase, PubMed, Web Science, Econlit, CNKI) up December 4, 2022. Technology appraisals from Canada, England, Australia, United...