A5115444847- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- MicroRNA in disease regulation
- RNA modifications and cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Ion channel regulation and function
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Memory and Neural Mechanisms
- Congenital Heart Disease Studies
- Cancer-related gene regulation
- Prenatal Screening and Diagnostics
- Neural dynamics and brain function
- Reproductive System and Pregnancy
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Diet and metabolism studies
- Sleep and Wakefulness Research
- Williams Syndrome Research
- Genetic and Kidney Cyst Diseases
- Inflammatory Bowel Disease
- Congenital heart defects research
- Pregnancy and preeclampsia studies
- Microtubule and mitosis dynamics
- Vector-borne infectious diseases
Shanghai Jiao Tong University
2013-2025
Shanghai University
2025
Zhejiang University
2016-2025
West China Medical Center of Sichuan University
2022-2025
Zhejiang Lab
2022-2025
Second Affiliated Hospital of Zhejiang University
2020-2025
Ruijin Hospital
2025
Jiangsu Province Hospital
2024
Shandong First Medical University
2024
Huadong Hospital
2021-2024
Microglia modulate memories Synaptic reorganization and circuit rewiring leads to loss or weakening of connections between neurons may result in the erasure previously formed memories. eliminate excessive synapses developing brain regulate dynamics synaptic throughout life. However, it is still unclear whether forgetting related microglia activity how memory adult brain. Wang et al. discovered that eliminated components hippocampus depleting inhibiting phagocytosis prevented forgetting....
Long non-coding RNAs (lncRNAs), a recently characterized class of RNAs, have been shown to important regulatory roles and are de-regulated in variety tumors. However, the contributions lncRNAs gastric carcinoma their functional mechanisms remain largely unknown. In this study, we found that lncRNA high expressed transcript 1 (lncRNA-GHET1) was up-regulated carcinoma. The over-expression correlates with tumor size, invasion poor survival. Gain-of-function loss-of-function analyses...
Although preclinical data suggested that tumor necrosis factor-alpha (TNF) neutralization in heart failure (HF) would be beneficial, clinical trials of TNF antagonists were paradoxically negative. We hypothesized induces opposing inflammatory and remodeling responses HF are TNF-receptor (TNFR) specific.HF was induced wild-type (WT), TNFR1(-/-), TNFR2(-/-) mice via coronary ligation. Compared with WT HF, 4-week postinfarction survival significantly improved both TNFR1(-/-) HF. sham, hearts...
We here evaluated the potential anti-colorectal cancer activity by erastin, a voltage-dependent anion channel (VDAC)-binding compound. Our in vitro studies showed that erastin exerted potent cytotoxic effects against multiple human colorectal cell lines, possibly via inducing oxidative stress and caspase-9 dependent apoptosis. Further, mitochondrial permeability transition pore (mPTP) opening was observed erastin-treated cells, which evidenced VDAC-1 cyclophilin-D (Cyp-D) association,...
Abstract The development of chemoresistance remains a major challenge that accounts for colorectal cancer (CRC) lethality. Dichloroacetate (DCA) was originally used as metabolic regulator in the treatment diseases; here, DCA assayed to identify mechanisms underlying CRC. We found markedly enhanced chemosensitivity CRC cells fluorouracil (5-FU), and reduced colony formation due high levels apoptosis. Using microarray assay, we noted miR-149-3p involved CRC, which modulated by wild-type p53...
Aldehydes are ubiquitous pollutants generated during the combustion of organic materials and present in air, water, food. Several aldehydes also endogenous products lipid peroxidation by-products drug metabolism. Despite well-documented high reactivity unsaturated aldehydes, little is known regarding their cardiovascular effects role cardiac pathology. Accordingly, we examined myocardial model aldehyde acrolein. In closed-chest mice, intravenous acrolein (0.5 mg/kg) induced rapid but...
Many types of multinucleated cells (syncytia) generated by cell-cell fusion are post-mitotic, but it remains unclear how this state is maintained and why. Here, we utilized the fluorescent ubiquitination-based cell-cycle indicator (Fucci) reporter system to show that human placental trophoblast were all in G0 phase before they fuse. Expression fusogenic protein (fusogen) Syncytin-2 was confined cells. Overexpression cycling overrode restriction enabled S/G2/M phases resulted unstable...
The enteric nervous system (ENS), the gut's intrinsic critical for gastrointestinal function and gut-brain communication, is believed to mainly originate from vagal neural crest cells (vNCCs) partially sacral NCCs (sNCCs). Resolving exact origins of ENS understanding congenital diseases but has been confounded by inability distinguish between both NCC populations in situ. Here, we aimed resolve mammalian ENS.
Antigenic variation is an effective strategy evolved by pathogenic microbes to avoid immune destruction. Variable Ags such as the variable major protein of Borrelia hermsii, variant surface glycoprotein African trypanosomes, and pilin Neisseria gonorrhoeae include immunodominant domain one or more invariable domains that are not antigenic. Short, nonantigenic, regions also may be present within domain. VlsE (variable protein-like sequence, expressed), Ag burgdorferi, Lyme disease spirochete,...
We systematically investigated the comparative efficacy of three different cytokine regimens, administered after a reperfused myocardial infarction, in regenerating cardiac tissue and improving left ventricular (LV) function. Wild-type (WT) mice underwent 30-minute coronary occlusion followed by reperfusion received vehicle, granulocyte colony-stimulating factor (G-CSF)+Flt-3 ligand (FL), G-CSF+stem cell (SCF), or G-CSF alone starting 4 hours reperfusion. In separate experiments, chimeric...
New neurons are continually born throughout adulthood in the subventricular zone of lateral ventricle and subgranular dentate gyrus hippocampus. The sequential synaptic integration adult-born has been widely examined rodents, but mechanisms regulating remain largely unknown. primary cilium, a microtubule–based signaling center, plays essential roles vertebrate development, including development central nervous system. We assembly function cilium hippocampal neurons. Strikingly, cilia absent...
Abstract Touch can positively influence cognition and emotion, but the underlying mechanisms remain unclear. Here, we report that tactile experience enrichment improves memory alleviates anxiety by remodeling neurons along dorsoventral axis of dentate gyrus (DG) in adult mice. Tactile induces differential activation structural modification dorsal ventral DG, increases presynaptic input from lateral entorhinal cortex (LEC), which is reciprocally connected with primary somatosensory (S1), to...
New neurons are abnormal in the adult hippocampus of Alzheimer's disease (AD) mouse models. The effects modulating neurogenesis on AD pathogenesis differ from study to study. We reported recently that ablation neural stem cells (aNSCs) was associated with improved memory Here, we found long-term potentiation (LTP) APP/PS1 mice after aNSCs. This effect confirmed hAPP-J20 mice, a second model. On other hand, exposure enriched environment (EE) dramatically increased number DCX+ neurons,...
Rhizoma coptidis (Huang-lian) and Asian ginseng have been widely used in the treatment of diabetes other concurrent diseases with apparent effects. This study investigated effects active ingredients R. ginseng, berberine ginsenoside Rb1, on depression-like behavior a rat model. The animal model was established via high-fat diet intraperitoneal injection streptozotocin, while animal's induced chronic unpredictable mild stress. These experimental rats were divided into four groups: control,...
Glutathione (GSH) is a tripeptide and natural reducing agent composed of glutamic acid, glycine, cysteine. Its level in the human body closely linked to health, such as diabetes, Alzheimer's disease, cancer. The supplementation exogenous GSH could bring health benefits detection food considerable importance. However, existing assays for high-performance liquid chromatography/mass spectrometry, electrochemiluminescence fluorescent nanoprobe were not satisfactory because disadvantages...