A5081375859- Cardiovascular and exercise physiology
- Adipose Tissue and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Berberine and alkaloids research
- Tryptophan and brain disorders
- Pharmacological Effects of Natural Compounds
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Cytokine Signaling Pathways and Interactions
- Autophagy in Disease and Therapy
- Ginseng Biological Effects and Applications
- Melanoma and MAPK Pathways
- Muscle metabolism and nutrition
- Exercise and Physiological Responses
- Pancreatic function and diabetes
- Traditional Chinese Medicine Analysis
- Quinazolinone synthesis and applications
- Nutrition and Health in Aging
- Stress Responses and Cortisol
- 3D Shape Modeling and Analysis
- Muscle Physiology and Disorders
- Inflammasome and immune disorders
- Protein Kinase Regulation and GTPase Signaling
- Circadian rhythm and melatonin
Beijing Sport University
2012-2025
Huazhong University of Science and Technology
2018-2024
Tongji Hospital
2018-2024
Zhujiang Hospital
2024
Southern Medical University
2024
South China Agricultural University
2024
Harbin Institute of Technology
2023
China Medical University
2008-2023
Institute of Process Engineering
2023
University of Chinese Academy of Sciences
2023
Elevated levels of plasma free fatty acid (FFA) and disturbed mitochondrial dynamics play crucial roles in the pathogenesis diabetic kidney disease (DKD).However, mechanisms by which FFA leads to damage glomerular podocytes DKD effects Berberine (BBR) on are not fully understood.Methods: Using db/db mice model cultured mouse podocytes, we investigated molecular mechanism FFA-induced disturbance testified BBR regulating dysfunction, podocyte apoptosis glomerulopathy progression DKD.Results:...
Background and Purpose Disordered lipid metabolism disturbed mitochondrial bioenergetics play pivotal roles in the initiation development of diabetic kidney disease (DKD). Berberine is a plant alkaloid, used Chinese herbal medicine. It has multiple therapeutic actions on diabetes mellitus its complications, including regulation glucose metabolism, improvement insulin sensitivity, alleviation oxidative damage. Here, we investigated reno‐protective effects berberine. Experimental Approach We...
More than 70% of patients with type 2 diabetes (T2DM) concomitantly suffer from Non-alcoholic fatty liver disease (NAFLD), and the coexistence interaction them increases intractability NAFLD. With protective effect against hepatic steatosis fibrosis, SIRT6 is becoming a notable target Diosgenin, an active monomer Chinese herbs, has been reported to protect NAFLD.This study aims figure out mechanism how diosgenin alleviate NAFLD in T2DM relationship SIRT6.In vivo studies used spontaneous...
Jiao-tai-wan (JTW), a classic herbal formula of traditional Chinese medicine recorded in Han Shi Yi Tong, has been used to alleviate sleep disorders since ancient times. In modern pharmacological research, JTW adopted for treating diabetes mellitus and even exerts antidepressant effects. However, the potential mechanisms deserve further elucidation. The prevalence combined with depressive disorder (DD) is continuing increase, yet it currently under-recognized its treatment remains...
Depression is a major global health issue that urgently requires innovative and precise treatment options. In this context, saikosaponin has emerged as promising candidate, offering variety of therapeutic benefits may be effective in combating depression. This review delves into the multifaceted potential saikosaponins alleviating depressive symptoms. We summarized effects on structural functional neuroplasticity, elaborated regulatory mechanism modulating key factors affect such...
Rhizoma coptidis (Huang-lian) and Asian ginseng have been widely used in the treatment of diabetes other concurrent diseases with apparent effects. This study investigated effects active ingredients R. ginseng, berberine ginsenoside Rb1, on depression-like behavior a rat model. The animal model was established via high-fat diet intraperitoneal injection streptozotocin, while animal's induced chronic unpredictable mild stress. These experimental rats were divided into four groups: control,...
Polycystic ovary syndrome (PCOS) is a clinical with reproductive and endocrine disorders. Berberine monomer from Chinese herbs such as Coptis chinensis, whose effect on improving ovulation endometrial receptivity of PCOS uncertain. To evaluate the berberine explore mechanism. The rat model was induced by intraperitoneal injection testosterone propionate. Then they divided into (Mod) group, low-dose (BL) high-dose (BH) group metformin (Met) well control (Con) established. Ovary morphology,...
Diabetic nephropathy (DN) is a serious complication of diabetes mellitus. DN the main cause end-stage renal disease (ESRD). SIRT6 becomes important target DN. Diosgenin (a monomer from Chinese herbs) probable to bind SIRT6.Based on studies presented in literature kidney injuries plus screening for binding effects drug Sirt6, we aimed carry out study assess diosgenin involved improving podocyte damage early phase DN..DN model was established spontaneous diabetic db/db mice. Animal experiment...
Abstract Exercise is a potential treatment to improve sleep quality in middle-aged and elderly individuals. Understanding exercise-induced changes functional plasticity of brain circuits that underlie improvements among older adults can inform problems. The aim the study identify effects 12-week exercise program on connectivity with insomnia. trial was registered Chinese Clinical Trial Register (ChiCTR2000033652). We recruited 84 healthy sleepers 85 individuals Participants insomnia were...
Human tissues and organs have heterogeneous structures with multiple property gradients, which are difficult to restore by single-material bioprinting technology. The advances in multi-material technologies shown great promise replicating tissue-engineered constructs one or more functional gradients. In this study, a 3D printing system based on digital light processing (DLP) was developed, could efficiently complete tasks. An appropriate concentration of an ultraviolet absorber selected...
Diabetes is a group of metabolic disorders with an increased risk developing cognitive impairment and dementia. The hippocampus in the forebrain contains abundance insulin receptors related to function plays important role pathophysiology neurodegenerative disorders. Berberine from traditional Chinese medicine has been used treat diabetes diabetic impairment, although its mechanisms are largely unknown. In this study, STZ rat model feeding high-fat diet was test effects berberine compared...
Jiao-tai-wan (JTW) has been often used to treat insomnia and diabetes mellitus. Recent studies found its antidepressant activity, but the related mechanism is not clear. This study evaluate therapeutic effects of JTW on chronic restraint stress (CRS)-induced depression mice explore potential mechanisms.CRS was set up a model. Mice in different groups were treated with 0.9 % saline, fluoxetine. After last day CRS, behavioral tests conducted. The levels neurotransmitters, inflammatory...
Depression, a global neuropsychiatric disorder, brings serious burden to patients and society as its incidence continues rise. Berberine is one of the main compounds variety Chinese herbal medicines has been shown have multiple pharmacological effects. However, whether berberine can exert antidepressant effects in vivo vitro related mechanisms remain be explored. The chronic restraint stress (CRS) method corticosterone (CORT) were applied simulate depression-like behavior neuronal apoptosis...
Abstract Background The incidence of diabetes mellitus (DM) and depression is increasing year by around the world, bringing a serious burden to patients their families. Jiao-tai-wan (JTW), well-known traditional Chinese medicine (TCM), has been approved have hypoglycemic antidepressant effects, respectively, but whether JTW such dual effects its potential mechanisms still unknown. This study evaluate therapeutic on chronic restraint stress (CRS)-induced DM combined with mice, explore...
Ginsenoside Rb1 (Rb1) is a biologically active component of ginseng [Panax C.A. Meyer (Araliaceae)].This study determined the underlying mechanisms treatment that acted on diabetes-injured lungs in diabetic rats.Streptozotocin (STZ)-induced rat model was used. Male Sprague-Dawley (SD) rats were divided into four groups (n = 10): control, (20 mg/kg), insulin (15 U/kg to attain euglycaemic state) and (untreated). After for six weeks, oxidative stress assay; histological ultrastructure...
High levels of physical activity (PA) and cardiorespiratory fitness (CRF) are each associated with a favorable cardiovascular disease (CVD) risk profile. However, the relationship between CRF obesity is still inconsistent across studies, there has been no thorough exploration independent contribution to different CVD factors in Chinese women. This study investigated 40–49 year old women Beijing. The included 231 urban-dwelling asymptomatic Body mass index (BMI), body fat percentage (BF%),...