A5101802538- Berberine and alkaloids research
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Natural Antidiabetic Agents Studies
- Adipose Tissue and Metabolism
- Chromatography in Natural Products
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Sleep and Wakefulness Research
- Bioactive natural compounds
- MicroRNA in disease regulation
- Lipid metabolism and disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Dietary Effects on Health
- Circadian rhythm and melatonin
- Ginger and Zingiberaceae research
- Lipid metabolism and biosynthesis
- Pancreatic function and diabetes
- Cardiovascular Disease and Adiposity
- Cholesterol and Lipid Metabolism
- Cannabis and Cannabinoid Research
- Curcumin's Biomedical Applications
- Chronic Kidney Disease and Diabetes
Tongji Hospital
2016-2025
Huazhong University of Science and Technology
2016-2025
First Affiliated Hospital of Nanchang University
2020-2024
Nanchang University
2020-2024
University of Benin
2023
New York State College of Agriculture & Life Sciences
2023
Cornell University
2023
Shandong First Medical University
2016
Peking University
2015
Bruker (China)
2012
Elevated levels of plasma free fatty acid (FFA) and disturbed mitochondrial dynamics play crucial roles in the pathogenesis diabetic kidney disease (DKD).However, mechanisms by which FFA leads to damage glomerular podocytes DKD effects Berberine (BBR) on are not fully understood.Methods: Using db/db mice model cultured mouse podocytes, we investigated molecular mechanism FFA-induced disturbance testified BBR regulating dysfunction, podocyte apoptosis glomerulopathy progression DKD.Results:...
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic and characterized by excessive hepatic lipid accumulation. Many studies have suggested that overload key initial factor contributes to steatosis. Our previous study indicated diosgenin (DSG) has a beneficial effect on energy metabolism, but underlying mechanism remains unclear.Human normal hepatocytes (LO2 cells) were incubated with palmitic acid establish cell model of nonalcoholic liver. The effects DSG glucose uptake...
Background and Purpose Disordered lipid metabolism disturbed mitochondrial bioenergetics play pivotal roles in the initiation development of diabetic kidney disease (DKD). Berberine is a plant alkaloid, used Chinese herbal medicine. It has multiple therapeutic actions on diabetes mellitus its complications, including regulation glucose metabolism, improvement insulin sensitivity, alleviation oxidative damage. Here, we investigated reno‐protective effects berberine. Experimental Approach We...
Background: Intestinal mucosal barrier dysfunction plays an important role in the development of diabetes mellitus (DM). Berberine (BBR), a kind isoquinoline alkaloid, is widely known to be effective for both DM and diarrhea. Here, we explored whether anti-diabetic effect BBR was related intestine barrier. Methods Results: The rat model T2DM established by high glucose fat diet feeding intravenous injection streptozocin. Then, those diabetic rats were treated with at different concentrations...
More than 70% of patients with type 2 diabetes (T2DM) concomitantly suffer from Non-alcoholic fatty liver disease (NAFLD), and the coexistence interaction them increases intractability NAFLD. With protective effect against hepatic steatosis fibrosis, SIRT6 is becoming a notable target Diosgenin, an active monomer Chinese herbs, has been reported to protect NAFLD.This study aims figure out mechanism how diosgenin alleviate NAFLD in T2DM relationship SIRT6.In vivo studies used spontaneous...
Background Memory-impairment was one of the common characteristics in patients with diabetes mellitus. The release chronic inflammation mediators and insulin resistance diabetic brain gave rise to generation toxic factor Aβ42 which marker Alzheimer's disease (AD). In addition, impairment memory mellitus also correlated predominantly uptake/metabolism glucose medial prefrontal cortex (mPFC). Previously, anti-inflammation hypoglycemic effects berberine have been described peripheral tissues....
Abstract Backgrounds Inflammation is recognized as the key pathological mechanism of type 2 diabetes. The hypoglyceamic effects berberine (BBR) are related to inhibition inflammatory response, but not completely clear. Methods polarization Raw264.7 cells and primary peritoneal macrophages were induced by LPS, then underlying mechanisms BBR explored. An model was established LPS treatment at different concentrations for time. ELISA assay used detect secretions TNF-α. RT-PCR applied M1...
Diabetic nephropathy (DN) is a serious complication of diabetes mellitus. DN the main cause end-stage renal disease (ESRD). SIRT6 becomes important target DN. Diosgenin (a monomer from Chinese herbs) probable to bind SIRT6.Based on studies presented in literature kidney injuries plus screening for binding effects drug Sirt6, we aimed carry out study assess diosgenin involved improving podocyte damage early phase DN..DN model was established spontaneous diabetic db/db mice. Animal experiment...
Brown adipose tissue (BAT) plays a key role in thermogenesis to protect the body from cold and obesity. White (WAT) stores excess energy form of triglycerides. To better understand genetic effect on regulation WAT BAT, we investigated fat fraction (FF) two types tissues ob/ob, human BSCL2/ seipin gene knockout (SKO), Fsp27 ( −/− ), wild-type (WT) mice vivo using chemical shift selective imaging 1 H-MR spectroscopy. We reported that visceral volume was significantly larger ob/ob mice, but...
Excessive synthesis of triglycerides and cholesterol accelerates the progression hepatic steatosis in metabolic-associated fatty liver disease (MAFLD). However, precise mechanism by which 6-gingerol mitigates MAFLD model mice has yet to be fully understood. The present study observed that administration exhibited significant protective effects against obesity, insulin resistance, subjected a high-fat diet (HFD), mitigated lipid accumulation HepG2 cells treated with palmitate (PA). Following...
ABSTRACT Hepatic lipid droplet (LD) accumulation is a hallmark of nonalcoholic fatty liver disease (NAFLD). Although the clinical efficacy berberine (BBR) in treating NAFLD has been established, mechanism remains uncertain. This study to evaluate effects BBR on hepatic LDs and investigate underlying mechanisms. Using high‐fat diet‐induced obese (DIO) mice as model for NAFLD, was administered daily by gavage 4 weeks. Liver tissue examined changes deposition histology. Transcriptomics...
Background: Non-small cell lung cancer (NSCLC) is the leading cause of deaths all over world. Exosomes exert central roles in intercellular communication. Circular RNA Rho GTPase activating protein 10 (circARHGAP10) was related to development NSCLC. Nevertheless, it unclear whether circARHGAP10 can be mediated by serum-derived exosomes Materials and Methods: Protein expression CD63, CD81, family with sequence similarity 83F (FAM83F), glucose transporter 1 (Glut1), lactate dehydrogenase were...
Abstract Background Accumulating evidence indicated that necroptosis plays an essential role in the pathogenesis of inflammatory bowel disease (IBD). The O -linked β- N -acetylglucosaminylation ( -GlcNAcylation) necroptotic signal molecule receptor-interacting serine-threonine kinase 3 (RIPK3) was reported to exert a protective effect gut inflammation. Our recent study suggested traditional Chinese herbal formula Wu-Mei-Wan (WMW) as effective prescription mouse colitis. However, potential...
Understanding the regulatory mechanisms involving neuronatin (
To determine the effects and underlying mechanism of diosgenin (DSG) 5‐methoxypsoralen (5‐MOP), two main active components in classical Chinese prescription Hu‐Lu‐Ba‐Wan (HLBW), on insulin resistance, HepG2 cells were incubated medium containing insulin. Treatments with DSG, 5‐MOP, their combination performed, respectively. The result showed that incubation high concentration markedly decreased glucose consumption glycogen synthesis. However, treatment or significantly reversed condition...
Ban-xia-xie-xin-tang (BXXXT) has been applied in treating metabolic diseases, such as nonalcohol fatty liver disease, diabetes mellitus, and obesity. However, the underlying molecular mechanism of BXXXT mellitus is unknown.To clarify alleviating hepatic steatosis high-fat diet (HFD)-fed mice.After 12 weeks HFD treatment, mice were administered for 4 weeks. The main chemical components identified by UPLC-TQ-MS/MS. Indicators associated with insulin resistance lipid metabolism detected. effect...
Jiao-Tai-Wan (JTW), composed of Rhizome Coptidis and Cortex Cinnamomi, is a classical traditional Chinese prescription for treating insomnia. Several in vivo studies have concluded that JTW could exert its therapeutical effect insomnia rats. However, the specific mechanism still unclear. The present study aimed to explore on sleep obesity-resistant (OR) rats with chronic partial deprivation (PSD) clarify possible mechanism.JTW was prepared main components contained granules were identified...