A5100376108- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Bladder and Urothelial Cancer Treatments
- Cancer Genomics and Diagnostics
- Remote Sensing and LiDAR Applications
- Genetic factors in colorectal cancer
- Ovarian cancer diagnosis and treatment
- Lung Cancer Treatments and Mutations
- Signaling Pathways in Disease
- NF-κB Signaling Pathways
- Nuts composition and effects
- Land Use and Ecosystem Services
- Cancer, Stress, Anesthesia, and Immune Response
- Solar Radiation and Photovoltaics
- Point processes and geometric inequalities
- Galectins and Cancer Biology
- PARP inhibition in cancer therapy
- Music and Audio Processing
- Speech Recognition and Synthesis
- Ubiquitin and proteasome pathways
- Data Visualization and Analytics
Argonne National Laboratory
2025
Nanchang University
2021-2024
First Affiliated Hospital of Nanchang University
2021-2024
Nanjing Brain Hospital
2023
Nanjing Medical University
2023
First People's Hospital of Yunnan Province
2022
Kunming University of Science and Technology
2022
First Affiliated Hospital of Soochow University
2019-2022
Soochow University
2019-2022
First Affiliated Hospital of Zhengzhou University
2018-2020
Recent studies reveal that long non-coding RNAs (lncRNAs) have been shown to important regulatory roles in cancer biology, and lncRNA MALAT-1 expression is upregulated some tumors. However, the contributions of bladder metastasis remain largely unknown. In present study we evaluated tissues by real-time PCR, defined its biological functions. We verified levels were compared with adjacent normal tissues, was remarkably increased primary tumors subsequently metastasized, when those did not...
Maternally Expressed Gene 3 (MEG3) is an imprinted gene that encodes a long non-coding RNA (lncRNA) associated with tumorigenesis. Autophagy activated in cancer cells and contributes to tumor cell survival. However, little known about whether MEG3 regulates bladder development by controlling autophagy. In the study, we found levels were significantly reduced tissues compared normal controls, autophagy activity was increased tissues. A significant negative correlation observed between LC3-II...
microRNAs (miRNAs) have been proposed to be key regulators of diverse biological processes such as transcriptional regulation, cell growth and tumorigenesis. Wnt signaling plays an important role in the regulation tumorigenesis cancer progression. However, little is known about whether miR-144 regulates bladder proliferation by controlling signaling. In this study, we found that expression level significantly decreased lines well clinical tissues. inhibitor blocks endogenous promotes...
Glioblastoma multiforme (GBM) is extensively genetically and transcriptionally heterogeneous, which poses challenges for classification management. Long noncoding RNAs (lncRNAs) play a critical role in the development progression of GBM, especially tumor-associated immune processes. Therefore, it necessary to develop an immune-related lncRNAs (irlncRNAs) signature. Univariate multivariate Cox regression analyses were utilized construct prognostic model. GBM-specific CeRNA PPI network was...
Abstract Background Epithelial-mesenchymal transition (EMT) has been associated with the angiogenesis and oncogenic phenotypes of multiple malignant tumors including bladder cancer (BCa). Circular RNAs (circRNAs) are recognized as crucial regulators in EMT. This study aims to illustrate possible role circular RNA_0000658 (circ_0000658) BCa underlying molecular mechanism. Methods The expression circ_0000658, microRNA (miR)-498, high mobility group AT-hook 2 (HMGA2) was assessed adjacent...
Chemotherapy resistance is the main cause of ovarian cancer progression and even death. However, there are no clear indicators for predicting risk drug in patients. Intra-tumor heterogeneity (ITH) one characteristics malignant tumors, which associated with treatment prognosis tumors. Accordingly, our study aims to investigate correlation between image features intra-tumor based on artificial intelligence.
The accurate modeling and prediction of solar ramping events are critical for enhancing the situational awareness power generation systems. impact weather conditions, including temperature, humidity, cloud density, on emergence position is well acknowledged. In addition, abnormal typically strongly correlated in space time, posing a challenge these with complex spatio-temporal correlations. To address this challenge, we propose novel categorical point process model that effectively addresses...
Abstract Bladder cancer is the most common malignancy with high recurrence. Currently, long noncoding RNAs (lncRNAs) have been suggested to play vital roles in pathogenesis of bladder cancer. The present study investigated role lncRNA MIR503 host gene (MIR503HG) by using both vitro and vivo functional assays. expression MIR503HG was downregulated tissues cell lines. Low associated advanced tumor stage, histological grade, lymph node metastasis. Ectopic inhibited proliferation, growth,...
Renal cell carcinoma (RCC) has been regarded as one of the most malignant tumor types. Chemotherapy (such sorafenib) is used common strategy for treating RCC. To date, whether long noncoding RNA KIF9-AS1 involved in RCC progression and drug resistance remains unknown. In this investigation, we detected gene expression levels by western blot RT-qPCR. MTT TUNEL experiments were to show viability apoptosis, respectively. overexpression led enhanced viability, increased IC50 value sorafenib,...
Parkinson's disease (PD), which is a neurodegenerative disease, requires urgently needed biomarkers to explore its mechanism. We screened for differences in the expression of microRNAs (miRNAs) and identified miR-1976 as possible biomarker.Twenty-three patients 30 controls were included this study. Dopaminergic neurons from C57/BL mice cultured. The miRNA profiles analyzed using an microarray. MiR-1976 was that differentially expressed between PD age-matched controls. Lentiviral vectors...
Understanding the regulatory mechanisms involving neuronatin (
Bladder cancer (BC) is one of the most common malignant tumors in urinary system. Our research aimed to explore function and underlying mechanisms long noncoding RNA (lncRNA) PSMA3-AS1 BC. RT-qPCR was utilized detect levels PSMA3-AS1, miR-214-5p, PD-L1. ChIP assay employed confirm transcription factor PSMA3-AS1. Luciferase reporter carried out demonstrate relationships between miR-214-5p or The diagnostic value evaluated by ROC curve. CCK-8, wound healing, transwell, flow cytometry assays...
ZMYND8, an epigenetic regulator, was identified as a common oncogene across various tumors. However, little reported about the association between ZMYND8 and bladder cancer. Besides, aberrant mechanisms that contribute to abnormal expressions still remain unclear. In current study, we first found protein levels were significantly elevated in Bca samples versus normal tissues, but not mRNA levels. We then utilized Cell Counting Kit-8 (CCK-8) assay, clone formation assay transwell analysis...
The aim of this study was to explore the functions and associated mechanisms long noncoding RNA LINC02487 in oral squamous cell carcinoma (OSCC). relative expression levels OSCC lines tissue samples were examined by RT-qPCR. Intracellular localization determined using fluorescence situ hybridization. cloned into pCMV-puro vector then introduced cells lentiviral transfection. Cell processes, such as proliferation, apoptosis, migration, invasion, subsequently examined. LINC02487-binding...
Iron overload is directly associated with diabetes mellitus, loss of islet beta cell, and insulin resistance. Likewise, long noncoding RNA (lncRNA) type 2 (T2D). Moreover, lncRNAs could be induced by iron overload. Therefore, we are going to explore the molecular mechanism lncRNA XIST in overload-related T2D. Real-time quantitative PCR Western blot were used detect gene protein levels, respectively. TUNEL MTT assay performed examine cell survival. The glucose test strip, colorimetric...
The effect and mechanism of Galectin-3 gene expression on proliferation, invasion, apoptosis oral squamous cell carcinoma (OSCC) were investigated.Reverse transcription-polymerase chain reaction (RT- PCR) Western blotting used to detect the mRNA protein in OSCC. OSCC Tca8113 was divided into control, negative transfection groups. Galectin-3, matrix metalloproteinase (MMP)-2, MMP-9, Cleaved Caspase-3, β-catenin, Cyclin D1 after for 48 h each group. Cell proliferation detected by CCK8....
Modeling and predicting solar events, particularly the ramping event, is critical for improving situational awareness power generation systems. It has been acknowledged that weather conditions such as temperature, humidity, cloud density can significantly impact emergence position of events. As a result, modeling these events with complex spatio-temporal correlations highly challenging. To tackle question, we adopt novel categorical point process model, which intuitively effectively...
A novel long-term information feature for language identification called shifted cepstra curve (SCC) is presented in this paper. Long-term consists of over multiple frames, which are commonly used systems. For instance, parallel phone recognition model (PPRLM), the vector contains not only surpassing frames but also linguistic knowledge [1]. However high computational cost modeling gram may preclude their use tasks demand low memory. By contrast, experiments have proved that linguistics...
Abstract Objective: The aim of this study is to explore the functions and mechanisms long non-coding RNA LINC02487 in oral squamous cell carcinoma(OSCC). Materials methods: Relative expression level OSCC lines samples were examined by qRT-PCR. Intracellular localization was done using fluorescence situ hybridization. cloned into pCMV-puro vector, transfected HN6 HN30 lentivirus. Cell as proliferation, apoptosis, cycle, migration invasion subsequently. binding protein explored ChIRP-MS. And...
Objective: The aim of this study is to explore the functions and mechanisms long non-coding RNA LINC02487 in oral squamous cell carcinoma(OSCC).Materials methods: Relative expression level OSCC lines samples were examined by qRT-PCR. Intracellular localization was done using fluorescence situ hybridization. cloned into pCMV-puro vector, transfected HN6 HN30 lentivirus. Cell as proliferation, apoptosis, cycle, migration invasion subsequently. binding protein explored ChIRP-MS. And determined...