A5101949193- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Renal and related cancers
- Epigenetics and DNA Methylation
- Prostate Cancer Treatment and Research
- Cancer Genomics and Diagnostics
- Prostate Cancer Diagnosis and Treatment
- Crystallization and Solubility Studies
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Urinary and Genital Oncology Studies
- X-ray Diffraction in Crystallography
- IL-33, ST2, and ILC Pathways
- Advanced ceramic materials synthesis
- Estrogen and related hormone effects
- Circular RNAs in diseases
- Multiple and Secondary Primary Cancers
- Urinary Bladder and Prostate Research
- Helicobacter pylori-related gastroenterology studies
- HER2/EGFR in Cancer Research
- Cancer Cells and Metastasis
- Additive Manufacturing and 3D Printing Technologies
- Microbial infections and disease research
Nanchong Central Hospital
2025
Shenyang Jianzhu University
2023-2025
Jimei University
2025
Renji Hospital
2015-2024
Shanghai Jiao Tong University
2015-2024
Guangzhou Center for Disease Control and Prevention
2023-2024
PowerChina (China)
2024
Jinling Institute of Technology
2024
University of Florida
2019-2024
Chinese Academy of Sciences
1998-2024
Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 ( PINK1 ) PARK2/Parkin mutations cause autosomal recessive forms of Parkinson's disease. Upon a loss mitochondrial membrane potential (ΔΨ m in human cells, cytosolic Parkin has been reported to be recruited mitochondria, which is followed by stimulation autophagy. Here, we show that the relocation mitochondria induced collapse ΔΨ relies on expression overexpression WT but not mutated causes translocation even cells with normal ....
Recent studies reveal that long non-coding RNAs (lncRNAs) have been shown to important regulatory roles in cancer biology, and lncRNA MALAT-1 expression is upregulated some tumors. However, the contributions of bladder metastasis remain largely unknown. In present study we evaluated tissues by real-time PCR, defined its biological functions. We verified levels were compared with adjacent normal tissues, was remarkably increased primary tumors subsequently metastasized, when those did not...
Mutations in PTEN-induced putative kinase 1 (PINK1) are a cause of autosomal recessive familial Parkinson's disease (PD). Efforts deducing the PINK1 signaling pathway have been hindered by controversy around its subcellular and submitochondrial localization authenticity reported substrates. We show here that this mitochondrial protein exhibits topology which domain faces cytoplasm N-terminal tail is inside mitochondria. Although deletion transmembrane disrupts topology, common PD-linked...
Maternally Expressed Gene 3 (MEG3) is an imprinted gene that encodes a long non-coding RNA (lncRNA) associated with tumorigenesis. Autophagy activated in cancer cells and contributes to tumor cell survival. However, little known about whether MEG3 regulates bladder development by controlling autophagy. In the study, we found levels were significantly reduced tissues compared normal controls, autophagy activity was increased tissues. A significant negative correlation observed between LC3-II...
ABSTRACT RNA‐based biopesticides, heralding the third revolution in agricultural pest and disease control, emerge as pivotal for sustainable aquaculture China. This review delves into background, evolution, applications of RNA emphasizing their transformative impact on management. biopesticides offer myriad advantages. Utilizing dsRNA formulations ensures species‐specific targeting, thereby minimizing effects nontarget organisms. Swift environmental degradation addresses concerns about...
The incidence of prostate cancer (PCa) within Asian population used to be much lower than in the Western population; however, recent years and mortality rate PCa some countries have grown rapidly. This collaborative report summarized latest epidemiology information, risk factors, racial differences diagnosis, current status new trends surgery management novel agents for castration-resistant cancer. We believe such information would helpful clinical decision making urologists oncologists,...
BackgroundGlioblastoma (GBM), a highly malignant brain tumor, invariably recurs after therapy. Quiescent GBM cells represent potential source of tumor recurrence, but little is known about their molecular underpinnings.MethodsPatient-derived were engineered by CRISPR/Cas9-assisted knock-in an inducible histone2B-GFP (iH2B-GFP) reporter to track cell division history. We utilized in vitro 3D organoid approach isolate live quiescent (qGBM) and proliferative counterparts (pGBM) compare stem...
The aberrant expression of long noncoding RNAs (lncRNAs) has recently emerged as key molecules in human cancers; however, whether lncRNAs are implicated the progression clear cell renal carcinoma (ccRCC) remains unclear.Candidate were selected using microarray analysis and quantitative real-time PCR (qRT-PCR) was performed to detect ccRCC tissues. Overexpression knocking down experiments vivo vitro uncover biological roles lncRNA-URRCC on proliferation invasion. Microarray, chromatin...
Clear cell renal carcinoma (ccRCC) is a common kidney malignancy characterized by poor prognosis. Suppressor of variegation 3–9 homolog 1 (SUV39H1), which encodes histone H3 lysine 9 methyltransferase, has been reported to act as an oncogene in many cancers. However, it unclear whether SUV39H1 involved ccRCC. Here, we report that expression frequently upregulated ccRCC tumors and significantly correlated with progression. level independent risk factor for cancer prognosis, integration...
Hypoxia has been identified as a common contributor to tumor progression, including invasion and metastasis. However, the underlying mechanisms of enhanced metastasis under hypoxia remain unclear. A hypoxic microenvironment promotes renal cell carcinoma (RCC) by upregulating expression LOC100506178, which we named hypoxia-induced long non-coding RNA (lncRNA) associated with RCC (lncHILAR). Knockdown lncHILAR inhibited migration, whereas overexpression lncHILAR, conversely, facilitated...
Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by limited treatment options and high mortality. A better understanding of the molecular drivers IPF progression needed.
The opening of an energy gap in the electronic structure generally indicates presence interactions. In materials with low carrier density and short screening length, long-range Coulomb interaction favors spontaneous formation electron-hole pairs, so called excitons, excitonic at Fermi level. Excitonic host unique phenomena associated pair excitations. However, there is still no recognized single-crystal material order, which is, therefore, awaited condensed matter physics. Here, we show that...
It is increasingly clear that microRNAs (miRNAs) play an important role in many diseases, including tumorigenesis. However, the mechanisms by which miRNAs regulate bladder cancer development remain poorly understood. Here, we evaluated expression of microRNA‐203 (miR‐203) tissues using real‐time PCR, and defined target genes biologically functional effect luciferase reporter assay, flow cytometry western blot analysis. We first verified miR‐203 was decreased tissues. Moreover, ectopic...
Abstract Background and Objective High‐mobility group box 1 (HMGB1) is a versatile protein with intranuclear extracellular functions that involved in numerous biological pathological processes, such as transcription, DNA repair, response to infection inflammation. HMGB1 overexpression has been reported variety of human cancers. However, the clinical significance expression bladder cancer (BC) remains unclear. This study aimed investigate correlations between prognosis patients BC. Methods...
Micro RNA s (mi s), which negatively regulate protein expression by binding protein‐coding mRNA s, have been integrated into cancer development and progression as either oncogenes or tumor suppressor genes. mi R ‐30c was reported to be downregulated in several types of cancer. However, its role human renal cell carcinoma ( RCC ) remains largely unknown. Here, we show that is significantly tissues lines. We found miR‐30c downregulation could induced hypoxia cells a hypoxia‐inducible factors...