A5101697872- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Electrochemical sensors and biosensors
- Biosensors and Analytical Detection
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- RNA Interference and Gene Delivery
- Carbon and Quantum Dots Applications
- Electrochemical Analysis and Applications
- Gut microbiota and health
- Animal Nutrition and Physiology
- Polyoxometalates: Synthesis and Applications
- Genetic Neurodegenerative Diseases
- Epigenetics and DNA Methylation
- Inflammasome and immune disorders
- Moringa oleifera research and applications
- Infant Nutrition and Health
- Advanced Biosensing Techniques and Applications
- FOXO transcription factor regulation
- Immune Cell Function and Interaction
- Ferroptosis and cancer prognosis
- 2D Materials and Applications
- Single-cell and spatial transcriptomics
- Tryptophan and brain disorders
- Wnt/β-catenin signaling in development and cancer
Xinqiao Hospital
2025
Army Medical University
2025
Chinese Academy of Sciences
2023
People's Hospital of Kaizhou District
2022
Renji Hospital
2011-2021
Shanghai Jiao Tong University
2014-2021
China Agricultural University
2019-2021
Xinjiang Medical University
2020
Tumor Hospital of Xinjiang Medical University
2020
University of Jinan
2019
Single modal enzyme-linked immunosorbent assay (ELISA) covering colorimetric, fluorescence, and chemiluminescence techniques has been widely reported in recent years, whereas the combination of multiple signal channels one immunosensing platform still faces huge challenges. Multimodal imaging will provide more comprehensive precise diagnostic information by two or modalities. Inspired this concept, we established a new kind multimodal (M-ELISA) based on unique properties Au@Pt nanodendrites....
Abstract Bladder cancer represents a highly heterogeneous disease characterized by distinct histological, molecular and clinical phenotypes, detailed analysis of tumor cell invasion crosstalks within bladder cells has not been determined. Here, we applied droplet‐based single‐cell RNA sequencing (scRNA‐seq) to acquire transcriptional profiles 36 619 single isolated from seven patients. Single matched well with the pathological basal/luminal subtypes. Notably, in T1 tumors diagnosed as...
Background The immunotherapy targeting cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death ligand-1 (PD-L1) has achieved significant breakthroughs, but further improvements are still needed in cancer treatment. Methods We investigated orlistat, a drug approved by the Food Drug Administration for treatment of obesity found that it can enhance efficacy CTLA-4 blockade immunotherapy. conducted both vivo vitro experiments to explore mechanism which orlistat increased...
It is increasingly clear that microRNAs (miRNAs) play an important role in many diseases, including tumorigenesis. However, the mechanisms by which miRNAs regulate bladder cancer development remain poorly understood. Here, we evaluated expression of microRNA‐203 (miR‐203) tissues using real‐time PCR, and defined target genes biologically functional effect luciferase reporter assay, flow cytometry western blot analysis. We first verified miR‐203 was decreased tissues. Moreover, ectopic...
Notch signaling has been reported to play an essential role in tumorigenesis. Several studies have suggested that receptors could be oncoproteins or tumor suppressors different types of human cancers. Emerging evidence pathway regulates cell growth, apoptosis, cycle, and metastasis. In the current study, we explore whether Notch-1 regulate invasion migration as well EMT (epithelial-mesenchymal transition) prostate cancer cells. We found overexpression enhanced PC-3 However, downregulation...
Bladder cancer (BC) has become a serious health prob-lem and represents the second most commonly diagnosed urological tumor. Curcumin is principal active natural component of turmeric long been used in Asia as traditional herbal medicine. suppresses cell growth various types cancer, including BC, by regulating numerous molecular signaling pathways. The human trophoblast surface antigen 2 (Trop2) belongs to tumor-associated calcium signal transducer gene family. Trop2 described driver...
We first developed a green, mild and rapid method for the preparation of hierarchical manganese dioxide nanoflowers (MnO<sub>2</sub> NFs) as nanozymes with intrinsic oxidase-like activity using citric acid reduction potassium permanganate.
The inclusion of high-quality proteins are commonly used in swine production. Our research investigated the effects hydrolyzed wheat protein (HWP), fermented soybean meal (FSBM), and enzyme-treated (ESBM) on growth performance, antioxidant capacity, immunity, fecal microbiota metabolites weaned piglets. A total 144 piglets (weaned at 28 d) were allotted to 3 dietary treatments with 6 replicate pens per treatment 8 pen. This study included 2 periods: d 0 to14 for phase 1 15 2. Dietary...
An enzyme-free titer plate-based colorimetric assay utilizing functionalized mesoporous silica nanoparticles (MSNs) entrapping pH-indicator molecules has been developed. Pores in the were with phenyltrimethyloxysilane so that pH indicator (thymolphthalein or TP present case) can be tightly entrapped through π–π conjugation. To detect prostate specific antigen (PSA), TP-containing MSNs coated polyethylenimine (PEI), which favors attachment of negatively charged secondary anti-PSA antibody....
Metformin is the first line of oral antidiabetic drug in biguanide class for treatment type 2 diabetes. Increasing evidence has suggested that it a potential anti-tumor drug. However, mechanisms underlying inhibiting tumor development remain elusive, especially bladder tumors. T24 and J82 cell lines were used as an vitro model, 24 female SD rats to build N-methyl-N-nitrosourea (MNU)-induced orthotopic rat cancer model. Transfection lentivirus-based shRNA was construct STAT3-KNOCKDOWN line....
Polydopamine (PDA)-coated or encapsulating Cu3(PO4)2 (Cu3(PO4)2@PDA) nanosheets were synthesized, allowing the C-reaction protein (CRP) antibody to be attached electrostatically for immunosensing of CRP with simple photothermal detection. The antibody-covered Cu3(PO4)2@PDA replace antibody-conjugated enzyme in enzyme-linked immunosorbant assays. Owing high surface area 2-D-structured and coabsorption light near-IR spectrum by PDA, a small amount confined wells titer plate generates an easily...
Redox-active molybdophosphate produced by Cu<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub>nanospheres has been directly employed for signal amplification of an enzyme-free electrochemical immunosensor.
Nonluminal breast cancer has high early metastasis and treatment resistance, neoadjuvant chemotherapy (NAC) is needed. The presence of stem cells (CSC) epithelial-mesenchymal transition (EMT) leads to poor prognosis. This study investigated the changes in CSC markers EMT after NAC nonluminal their correlation with contrast-enhanced ultrasound (CEUS) features efficacy. Before NAC, range on CEUS was larger than that two-dimensional ultrasound, but it significantly smaller closer postoperative...
Objective To explore the expression and significance of N-cadherin in urothelial bladder cancer analyse its relation to clinicpathologic prognosis cancer.Methods The 145 25 normal tissues was detected by immunuhistochemisty,and correlations between clinicopathologic features were analysed.Results positive rate protein significantly higher than tissue (P＜0.01).The 38.6％ G1 cancer,58.4％ G2-G3 cancer,and difference significant (P =0.028).The lower non-muscle-invasive muscle invasive (45.7％ vs...
Abstract Background Rosemary extract (RE) has been reported to exert antioxidant property. However, the application of RE in late-phase laying hens on egg quality, intestinal barrier and microbiota, oviductal function not systematically studied. This study was investigated detect potential effects performance, serum parameters, heath, cecal microbiota metabolism, gene expressions hens. A total 210 65-week-old “Jing Tint 6” were divided into five treatments fed basal diet (control) or...
Two-dimensional (2D) materials are a new class of with interesting physical properties and applications ranging from nanoelectronics to sensing photonics. In addition graphene, the most studied 2D material, monolayers other layered such as semiconducting dichalcogenides MoS2 or WSe2 gaining in importance promising channel for field-effect transistors (FETs) phototransistors. However, it is unclear that how specific process electron transport affected by temperature. So, nowadays dynamics...