A5001531905- Antibiotic Resistance in Bacteria
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Pneumonia and Respiratory Infections
- Antibiotics Pharmacokinetics and Efficacy
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Urinary Tract Infections Management
- Streptococcal Infections and Treatments
- Bacterial biofilms and quorum sensing
- Antifungal resistance and susceptibility
- Pneumocystis jirovecii pneumonia detection and treatment
- Antibiotic Use and Resistance
- Infective Endocarditis Diagnosis and Management
- Bacterial Infections and Vaccines
- Fungal Infections and Studies
- Long-Term Effects of COVID-19
- Cytomegalovirus and herpesvirus research
- Infections and bacterial resistance
- Neutropenia and Cancer Infections
- Nosocomial Infections in ICU
- Mycobacterium research and diagnosis
- Respiratory viral infections research
- Sepsis Diagnosis and Treatment
- Enterobacteriaceae and Cronobacter Research
Samsung Medical Center
2016-2025
Sungkyunkwan University
2016-2025
Korea Disease Control and Prevention Agency
2022
Konkuk University Medical Center
2020
Jeju National University
2016
Office of Infectious Diseases
2000-2014
Asia Pacific Foundation of Canada
2014
Cardiff University
1983-2012
Korea Center for Disease Control and Prevention
2008-2009
Sogang University
2009
Methicillin-resistant Staphylococcus aureus (MRSA) is highly prevalent in hospitals many Asian countries. Recent emergence of community-associated (CA) MRSA worldwide has added another serious concern to the epidemiology S. infections. To understand changing infections countries, we performed a prospective, multinational surveillance study with molecular typing analysis.We evaluated prevalence methicillin resistance isolates CA and healthcare-associated (HA) infections, characterization...
ABSTRACT A total of 685 clinical Streptococcus pneumoniae isolates from patients with pneumococcal diseases were collected 14 centers in 11 Asian countries January 2000 to June 2001. The vitro susceptibilities the antimicrobial agents determined by broth microdilution test. Among tested, 483 (52.4%) not susceptible penicillin, 23% intermediate, and 29.4% penicillin resistant (MICs ≥ 2 mg/liter). Isolates Vietnam showed highest prevalence resistance (71.4%), followed those Korea (54.8%), Hong...
The effects of convalescent plasma (CP) infusion, one the treatment options for severe Middle East respiratory syndrome coronavirus (MERS-CoV) infections, have not yet been evaluated.Serological responses CP-infused MERS patients during 2015 Korean outbreak at a tertiary care centre were evaluated. Serological activity was evaluated with anti-MERS-CoV enzyme-linked immunosorbent assay (ELISA) immunoglobulin (Ig)G, ELISA IgA, immunofluorescence IgM and plaque reduction neutralization test...
Antimicrobial resistance in Streptococcus pneumoniae remains a serious concern worldwide, particularly Asian countries, despite the introduction of heptavalent pneumococcal conjugate vaccine (PCV7). The Network for Surveillance Resistant Pathogens (ANSORP) performed prospective surveillance study 2,184 S. isolates collected from patients with infections 60 hospitals 11 countries 2008 to 2009. Among nonmeningeal isolates, prevalence rate penicillin-nonsusceptible pneumococci (MIC, ≥ 4 μg/ml)...
BackgroundIn 2015, a large outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection occurred following single patient exposure in an emergency room at the Samsung Medical Center, tertiary-care hospital Seoul, South Korea. We aimed to investigate epidemiology MERS-CoV our hospital.MethodsWe identified all patients and health-care workers who had been with index case between May 27 29, 2015. Patients were categorised on basis their room: same zone as (group A), different...
Hospital-acquired pneumonia (HAP) and ventilator-associated (VAP) remain important causes of morbidity mortality. Increasing antimicrobial resistance has aroused the concern failure antibiotic treatment.To determine distribution bacterial isolates HAP VAP, their patterns, impact discordant therapy on clinical outcome in Asian countriesA prospective surveillance study was conducted 73 hospitals 10 countries from 2008-2009. A total 2,554 cases with or VAP adults were enrolled 2,445 collected...
Risk of Ischemic Stroke in Patients With Coronavirus Disease 2019 (COVID-19) vs Influenza
To investigate antimicrobial resistance in clinical isolates of Acinetobacter spp. from two Korean hospitals.Two hundred and sixty-five hospitals were collected identified to species level using partial rpoB gene sequences. Antimicrobial susceptibility testing was performed a broth microdilution method.rpoB sequences indicated that 214 (80.8%) baumannii, allowed these be classified into three subgroups (I, II III); 142 (53.6%) belonged subgroup I, 54 (20.4%) 18 (6.8%) III. Forty-eight...
ABSTRACT To investigate the evolutionary pattern and genotypic characteristics of methicillin-resistant Staphylococcus aureus (MRSA) strains in Asian region, 74 MRSA isolated from 12 countries were analyzed by multilocus sequence typing (MLST) SCC mec typing. Overall, a total 16 genotypes based on type types identified among countries. Data revealed two major Asia, with unique geographic distributions. By MLST analysis, all Korea Japan except one belonged to clonal complex 5 (CC5) while most...
To investigate the impact of imipenem resistance on mortality rate among patients with Acinetobacter bacteraemia.A retrospective, pairwise-matched (1:1), risk-adjusted (age, Pitt bacteraemia score) cohort study was performed at three tertiary care hospitals in Korea from January 2000 to June 2005.Forty non-susceptible (INAB group) and 40 matched subjects (1:1 ratio) imipenem-susceptible (ISAB were included. Both groups had similar clinical features related severity illness. The 30 day higher...
This study compares the effectiveness of Pitt bacteremia score, Charlson weighted index comorbidity, and Acute Physiology Chronic Health Evaluation II (APACHE II) scoring systems for prediction mortality in intensive care unit (ICU) patients with sepsis using retrospective observational method on 134 ICU-acquired sepsis. The statistical analyses show several important findings. First, score is significantly correlated APACHE system (correlation coefficient = 0.738, P < 0.001). Second,...
Background. There have been few reports on the causes and treatment outcomes for nosocomial spontaneous bacterial peritonitis (SBP) in patients with liver cirrhosis. Methods. We performed a retrospective cohort study to compare microbiological clinical characteristics versus community-acquired SBP. All SBP, whom culture was proven be positive SBP at Samsung Medical Center (Seoul, Republic of Korea) from 1 January 2000 through 31 June 2007, were included. records laboratory data reviewed....
BackgroundAfter the 2015 Middle East respiratory syndrome (MERS) outbreak in Korea, prediction of pneumonia development and progression to failure was emphasized control MERS outbreak.MethodsMERS-CoV infected patients who were managed a tertiary care center during Korean reviewed. To analyze predictive factors for failure, we evaluated clinical variables measured within three days from symptom onset.ResultsA total 45 included study: 13 (28.9%) did not develop pneumonia, 19 developed without...
Background: From May to July 2015, the Republic of Korea experienced largest outbreak Middle East respiratory syndrome (MERS) outside Arabian Peninsula.A total 186 patients, including 36 deaths, had been diagnosed with MERS-coronavirus (MERS-CoV) infection as September 30th, 2015.Materials and Methods: We obtained information patients who were confirmed have MERS-CoV infection.MERS-CoV was using real-time reverse-transcriptase polymerase chain reaction assay. Results:The median age 55 years...
Objectives: To investigate antibody production in asymptomatic and mild COVID-19 patients. Methods: Sera from to severe patients were collected. Microneutralization (MN), fluorescence immunoassay (FIA), enzyme-linked immunosorbent assay (ELISA) performed. Results: A total of 70 laboratory-confirmed evaluated, including 15 asymptomatic/anosmia, 49 symptomatic, 6 pneumonia The the neutralizing was observed 100% pneumonia, 93.9% 80.0% asymptomatic/anosmia groups. All group showed high MN titer...
Background:The mortality risk of coronavirus disease 2019 (COVID-19) is higher in patients with older age, and many elderly are reported to require advanced respiratory support.Methods: We reviewed medical records 98 aged ≥ 65 years who were hospitalized COVID-19 during a regional outbreak Daegu/Gyeongsangbuk-do province Korea.The outcome measures in-hospital the treatment mechanical ventilation (MV) or high-flow nasal cannula (HFNC).Results: The median age was 72 years; 55.1% female.Most...
Background: Nonpharmaceutical intervention strategy is significantly important to mitigate the coronavirus disease 2019 (COVID-19) spread.One of interventions implemented by government a school closure.The Ministry Education decided postpone opening from March 2 April 6 minimize epidemic size.We aimed quantify closure effect on COVID-19 epidemic.Methods: The potential effects were measured using mathematical model considering two age groups: children (aged 19 years and younger) adults over...
Abstract In 2015, we experienced the largest in-hospital Middle East respiratory syndrome (MERS) outbreak outside Arabian Peninsula. We share infection prevention measures for surgical procedures during unexpected at our hospital. reviewed all forms of related documents and collected information through interviews with healthcare workers After onset outbreak, a multidisciplinary team devised institutional MERS-control guidelines. Two standard operating rooms were converted to temporary...