A5081036132- Antimicrobial Resistance in Staphylococcus
- SARS-CoV-2 and COVID-19 Research
- Bacterial Identification and Susceptibility Testing
- Pneumonia and Respiratory Infections
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- Bacterial Infections and Vaccines
- Autoimmune and Inflammatory Disorders Research
- Infective Endocarditis Diagnosis and Management
- Streptococcal Infections and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Immune Response and Inflammation
- Cytomegalovirus and herpesvirus research
- Parvovirus B19 Infection Studies
- Inflammasome and immune disorders
- HER2/EGFR in Cancer Research
- Platelet Disorders and Treatments
- Herpesvirus Infections and Treatments
- Dermatology and Skin Diseases
- Cardiac Valve Diseases and Treatments
- Otolaryngology and Infectious Diseases
- Syphilis Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Genital Health and Disease
- Diphtheria, Corynebacterium, and Tetanus
Seoul Medical Center
2012-2024
Seoul Veterans Hospital
2003-2023
Mayo Clinic
2010-2015
Ibero American University
2015
National Cancer Institute
2010
Jacksonville College
2010
Mayo Clinic in Florida
2010
WinnMed
2010
Mayo Clinic in Arizona
2010
NSABP Foundation
2010
Although several antiviral agents have become available for coronavirus disease 2019 (COVID-19) treatment, oral drugs are still limited. Camostat mesylate, an orally bioavailable serine protease inhibitor, has been used to treat chronic pancreatitis in South Korea, and it vitro inhibitory potential against severe acute respiratory syndrome 2 (SARS-CoV-2). This study was a double-blind, randomized, placebo-controlled, multicenter, phase clinical trial mild moderate COVID-19 patients. We...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant (B.1.1.529) is dominating disease 2019 (COVID-19) worldwide. waning protective effect of available vaccines against the a critical public health issue. This study aimed to assess impact third COVID-19 vaccination on immunity SARS-CoV-2 BA.1 strain in older individuals.
Staphylococcus aureus, the most common cause of wound infection, produces several exotoxins, including superantigens (SAgs). SAgs are potent activators immune system. Given this unique property, we hypothesized that produced by S. aureus in wounds would have local, as well systemic immunologic effects. We tested our hypothesis using a novel staphylococcal skin infection model transgenic mice expressing HLA-DR3. Skin were left uninfected or colonized with strains producing an isogenic strain...
We tested the in vitro susceptibilities of 603 enterococcal isolates from eight tertiary-care hospitals Korea. The quinupristin-dalfopristin resistance rate Enterococcus faecium was very high (25 isolates, 10.0%). It suggested that both clonal spread and sporadic emergence quinupristin-dalfopristin-resistant may explain prevalence
The pathogenesis of herpes zoster is closely linked to reduced varicella-zoster virus-specific cell-mediated immunity. However, little known about the interplay between natural killer cells and psychological stress in zoster. This study aimed investigate possible associations among cells, T Interferon-gamma secretion from cell, events, cognition scale scores cytomegalovirus-specific immunity were compared 44 patients with age- gender-matched control subjects. A significantly lower median...
Human (H) cytomegalovirus (CMV) infections are a major cause of morbidity and mortality among kidney transplants. We performed prospective study to evaluate the clinical usefulness HCMV antigenemia assay for preemptive treatment after transplantation.A total 100 patients were followed up by at posttransplantation weeks 1, 3, 5, 7, 9, 13, 17, 21. Asymptomatic with positive observed without specific antiviral therapy.Most had been given cyclosporine A- prednisolone-based immunosuppressive...
Eunsin Bae, M.D., Choon Kwan Kim, Jung-Hyun Jang, Heungsup Sung, YounMi Choi, M.D. Ph.D., and Mi-Na Ph.D.. Ann Lab Med 2019;39:158-66. https://doi.org/10.3343/alm.2019.39.2.158
ABSTRACT Pulsed-field gel electrophoresis, ribotyping, and fingerprinting analysis of 22 invasive isolates multidrug-resistant (MDR) pneumococci from Korea showed that 59 to 82% were genetically related. DNA sequencing the PBP 2B gene relatively uniform alterations in nucleotides (5.4 7.8%) amino acids (3.0 4.3%), while Asn-276→Lys, Arg-285→Cys Ser-305→Phe substitutions unique Korean MDR strains, suggesting spread a few epidemic clones resistant within Korea.
With the widespread emergence of antimicrobial resistance, combination regimens ceftriaxone and vancomycin (C+V) or rifampin (C+R) are recommended for empirical treatment pneumococcal meningitis. To evaluate therapeutic efficacy meropenem (M), we compared various in a rabbit model meningitis caused by penicillin-resistant Streptococcus pneumoniae (PRSP). Therapeutic was also evaluated final bacterial concentration cerebrospinal fluid (CSF) at 24 hr. Each group consisted six rabbits. C+V...
Necrotizing fasciitis usually occurs after dermal injury or through hematogenous spread. To date, few cases have been reported as necrotizing of the thigh secondary to rectal perforation in cancer patients. A 66-year-old male complained pelvic and pain subsequently developed his right thigh. Four years earlier, he had undergone a low anterior resection radiotherapy due cancer. An ulcerative lesion observed around anastomosis site during colonoscopy that performed two months earlier. Pelvic...
Regdanvimab is a novel neutralizing antibody agent used for the treatment of coronavirus disease 2019 (COVID-19). However, effectiveness regdanvimab in delta-variant patients has rarely been investigated. We examined clinical outcomes and adverse events COVID 19 treated with era. Data were collected from laboratory-confirmed COVID-19 hospitalized who received 2021 categorized into pre-delta delta variant groups. The primary outcome was need oxygen therapy. Rescue therapy, improvement,...
Abstract Identification of HER2 as an important cellular marker in the biology and treatment breast cancer has highlighted importance reliable testing methodology. Controversy exists regarding type test, reliability, definition positivity, which test may best predict for patient (pt) efficacy to anti-HER2 therapies. Purpose: To determine concordance between results by 3 central laboratories, impact round-robin adjudication discordant cases, heterogeneity using specimens from adjuvant trials...
Background and Objectives:Antibiotic prophylaxis of infective endocarditis is required before high-risk procedures in patient with heart diseases. Although guidelines for the prevention were proposed by American Heart Association 1997, compliance to these recommendations has not been evaluated Korea. Subjects Methods:This was a retrospective, multicentered study 8 Korean university hospitals. Patients diseases, having undergone invasive dental between Jan. 1, 2000 Dec. 31, 2003, enrolled....
혈액배양검사는 혈류감염의 신속하고 정확한 진단을 위한 유일한 표준검사법이며, 패혈증이 의심되는 환자에서 원인균 의 검출과 동정, 항균제 감수성 여부를 파악하는데 매우 중요 하다[1].그러나 혈액배양에서 균 분리 빈도 및 병원균 분포, 결과 양상은 병원과 환자의 특성, 지역, 시기에 따라 다른 양상을 보일 수 있다.국내에서 균혈증 항 균제 양상에 대해 과거 여러 차례 보고된 바 있으나, 최 근의 추세는 별도
Adult onset Still's disease (AOSD) is a systemic autoinflammatory disorder that presents with recurrent fever, extreme fatigue, and joint pain.Pulmonary involvement not uncommon and, although rare, severe pneumonitis can progress to respiratory failure.Still's disease-associated generally treated immunosuppressive agents, but improvement in our understanding of inflammatory processes led us explore alternative agents.Anakinra an interleukin-1 receptor antagonist used treat disorders...
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