A5068604856- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Poxvirus research and outbreaks
- Bacillus and Francisella bacterial research
- Herpesvirus Infections and Treatments
- Rabies epidemiology and control
- Virology and Viral Diseases
- Microbial infections and disease research
- Long-Term Effects of COVID-19
- Viral Infections and Vectors
- Animal Virus Infections Studies
- COVID-19 Impact on Reproduction
- Brucella: diagnosis, epidemiology, treatment
- Influenza Virus Research Studies
- Advanced biosensing and bioanalysis techniques
- Streptococcal Infections and Treatments
- COVID-19 diagnosis using AI
- Burkholderia infections and melioidosis
- Biosensors and Analytical Detection
- Malaria Research and Control
- Mosquito-borne diseases and control
- Vector-borne infectious diseases
- Celiac Disease Research and Management
- Dermatological diseases and infestations
Research Medical Center
2024
National Medical Center
2020-2024
Korea University
2017-2024
University of Douala
2021
Korea National Institute of Health
2015-2017
Korea Center for Disease Control and Prevention
2016
Korea Disease Control and Prevention Agency
2016
The previous outbreaks of SARS-CoV and MERS-CoV have led researchers to study the role diagnostics in impediment further spread transmission. With recent emergence novel SARS-CoV-2, availability rapid, sensitive, reliable diagnostic methods is essential for disease control. Hence, we developed a reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay specific detection SARS-CoV-2. primer sets RT-LAMP were designed target nucleocapsid gene viral RNA, displayed limit 102...
Since severe acute respiratory syndrome-coronavirus-2 variant B.1.1.529 (omicron) was first reported to the World Health Organization on November 24, 2021, cases of omicron have been detected in more than 90 countries over last month. We investigated clinical and epidemiological characteristics 40 patients with who had isolated at National Medical Center South Korea during December 4-17, 2021. The median age 39.5 years. Twenty-two (55%) were women. Seventeen (42.5%) fully vaccinated, none...
Cases of laboratory-confirmed SARS-CoV-2 reinfection have been reported in a number countries. Further, the level natural immunity induced by infection is not fully clear, nor it clear if primary protective against reinfection. To investigate potential association between serum antibody titres and SARS-CoV-2, ferrets with different levels NAb after were subjected to heterologous strain. All reinfected showed active virus replication upper respiratory gastro-intestinal tracts. However, high...
Omicron has become the globally dominant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant, creating additional challenges due to its ability evade neutralization. Here, we report that neutralizing antibodies against variants are undetected following COVID-19 infection with ancestral or past SARS-CoV-2 variant viruses after two-dose mRNA vaccination. Compared vaccination, a three-dose vaccination course induces broad antibody responses improved durability different...
Abstract Background The immunologic features of children with coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) are not clearly delineated. This study was conducted to evaluate SARS-CoV-2-specific antibody responses in COVID-19. Methods levels anti-spike (S) IgG, anti-SARS-CoV-2 and neutralizing (NAb) were measured during various time points <19 years age COVID-19 South Korea from February 2020 September 2020. Results One hundred sixty-five...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant (B.1.1.529) is dominating disease 2019 (COVID-19) worldwide. waning protective effect of available vaccines against the a critical public health issue. This study aimed to assess impact third COVID-19 vaccination on immunity SARS-CoV-2 BA.1 strain in older individuals.
Concerns about the effectiveness of current vaccines against rapidly spreading severe acute respiratory syndrome-coronavirus-2 omicron (B.1.1.529) variant are increasing. This study aimed to assess neutralizing antibody activity wild-type (BetaCoV/Korea/KCDC03/2020), delta, and variants after full primary booster vaccinations with BNT162b2. A plaque reduction neutralization test was employed determine 50% dilution (ND
A 35-year-old man who returned from Germany developed fever, generalized pain, severe anal and skin rash, confirmed to be monkeypox (mpox). While he was previously human immunodeficiency virus infected, antiretroviral therapy ensured his immunocompetence. The mpox-related prodromal symptoms disappeared before isolation, subsequent several vesicular lesions healed after admission. moderate pain persisted for a few days, it improved during hospitalization. mpox no longer detected in samples...
Background Rabies is a major public health problem with fatality rate close to 100%; however, complete prevention can be achieved through pre- or post-exposure prophylaxis. The rapid fluorescent focus inhibition test (RFFIT) one of the recommended testing methods determine production neutralizing antibodies after vaccination. Here, we report development new monoclonal antibody (mAb) designed react specifically virus (RABV) phosphoprotein (P protein), and evaluation its applicability RFFIT...
ObjectivesThe aim of this study was to investigate the seroprevalence antibodies against scrub typhus, murine typhus and spotted fever groups among North Korean refugees within 1 year their arrival in South Korea.MethodsWe recruited who had settled Korea after a short stay third country did not have any health problems. The antibody titer measured using commercial indirect fluorescence assay immunoglobulin G kit.ResultsThe 99 participants 22.2%, 17.2%, 10.1%, respectively, with 8.1% testing...
Hyeong Nyeon Kim, M.D., Mina Hur, Hee-Won Moon, Hee Sook Shim, M.T., Hanah Misuk Ji, Yeo-Min Yun, Sung-Yong Jihye Um, B.S., Yeong Seon Lee, Ph.D., and Do Hwang, Ph.D.. Ann Lab Med 2016;36:390-2. https://doi.org/10.3343/alm.2016.36.4.390
Middle East respiratory syndrome (MERS) is a highly lethal disease caused by zoonotic betacoronavirus. The development of effective vaccines and control measures requires thorough understanding the immune response to this viral infection.We investigated cellular responses up 5 years after infection in cohort 59 MERS survivors performing enzyme-linked immunospot assay intracellular cytokine staining stimulation peripheral blood mononuclear cells with synthetic peptides.Memory T-cell were...
A global mpox outbreak occurred in 2022, and a domestic started South Korea April 2023. This study aimed to evaluate the clinical characteristics, viral shedding, immune response of Korea.
Background: A global mpox outbreak occurred in 2022 and a domestic started South Korea April 2023. This study aimed to evaluate the clinical characteristics, viral shedding, immune response of Korea.Methods: Patients hospitalized with National Medical Center between September 2022, June 2023, were included this study. Oropharyngeal (OP), anogenital lesion (AL), skin (SL) swabs blood samples collected monkeypox virus (MPXV) DNA using real-time polymerase chain reaction (RT-PCR) culture assay...
Abstract Natural Monkeypox virus infection induced significantly higher neutralizing antibody titers than Jynneos vaccination, with similar decay rates beyond 6 months. recipients prior smallpox vaccination showed levels comparable to mpox convalescents.
While a live-attenuated Yellow fever (YF) vaccine is known to elicit durable immunity, antibody titers may wane after vaccination. This study evaluated the long-term immunity vaccination against YF among individuals who reside in Korea and received with virus-17D prior international travel. Serum was collected between December 2018 2019 at National Medical Center, Republic of from recipients were vaccinated more than five years sample collection. Long-term assessed using three serological...