A5058610860- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Viral gastroenteritis research and epidemiology
- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- COVID-19 Impact on Reproduction
- COVID-19 and Mental Health
- Virus-based gene therapy research
- Influenza Virus Research Studies
- COVID-19 and healthcare impacts
- Animal Virus Infections Studies
- Actinomycetales infections and treatment
- Long-Term Effects of COVID-19
- Coronary Artery Anomalies
- Herpesvirus Infections and Treatments
- Renal Diseases and Glomerulopathies
- Urinary Tract Infections Management
- Microbial infections and disease research
- Plant-based Medicinal Research
- Autoimmune Bullous Skin Diseases
- Microbial Metabolism and Applications
- Neonatal and Maternal Infections
- Kawasaki Disease and Coronary Complications
- Chronic Lymphocytic Leukemia Research
Seoul National University Children's Hospital
2017-2025
Seoul National University
2021-2025
Konkuk University Medical Center
2022-2024
New Generation University College
2021-2022
Korea Disease Control and Prevention Agency
2021
Seoul National University Hospital
2019-2021
Data on the clinical characteristics of pediatric patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant infection are limited. We aimed to evaluate features and outcomes children SARS-CoV-2 before after omicron dominance in Korea.A multicenter retrospective cohort study was conducted hospitalized aged ≤ 18 years laboratory-confirmed at five university hospitals South Korea. The periods were divided into delta (from August 23, 2021 January 2, 2022) 30 March 31,...
Background: The COVID-19 pandemic’s transition to an endemic phase emphasizes the importance of vaccination. Despite initial strong immunogenicity, waning vaccine-induced immunity requires further investigation. Therefore, this study evaluated immunogenicity BNT162b2 vaccine in adolescents, focusing on spike-specific and neutralizing antibody kinetics following primary booster vaccinations as well impact breakthrough infections. Methods: This observational included 157 adolescents 12–17...
Parainfluenza virus type 3 (PIV3) and respiratory syncytial (RSV) B epidemics occurred in South Korea late 2021. We investigated epidemiological changes of PIV3 RSV infections Korean children before during the coronavirus disease 2019 (COVID-19) pandemic.In this multicenter retrospective study, we enrolled patients aged less than 19 years with or infection four university hospitals from January 2018 to 2022. Demographic clinical data were extracted subject's medical records analyzed for each...
Abstract Background The immunologic features of children with coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) are not clearly delineated. This study was conducted to evaluate SARS-CoV-2-specific antibody responses in COVID-19. Methods levels anti-spike (S) IgG, anti-SARS-CoV-2 and neutralizing (NAb) were measured during various time points <19 years age COVID-19 South Korea from February 2020 September 2020. Results One hundred sixty-five...
1/2 https://jkms.orgKawasaki disease (KD) is an acute febrile systemic vasculitis of early childhood with a predilection for the coronary arteries.Since recent reports from North America and European countries on Kawasaki-like or multisystem inflammatory syndrome in children (MIS-C) possible association coronavirus disease-19 (COVID-19), 1,2 we explored whether this has been observed Korean children.The incidence KD Korea estimated to 217.2 per 100,000 less than 5 years old, 10-30 fold...
Background: Invasive bacterial infection (IBI) remains a major burden of mortality and morbidity in children. As coronavirus disease 2019 (COVID-19) emerged, stringent nonpharmaceutical interventions (NPIs) were applied worldwide. This study aimed to evaluate the impact NPIs on pediatric IBI Korea. Methods: From January 2018 December 2020, surveillance for IBIs caused by 9 pathogens ( S. pneumoniae , H. influenzae N. meningitidis agalactiae pyogenes aureus Salmonella species, L....
Background: Coronavirus disease 2019 (COVID-19) is generally mild in children; however, severe or critical cases may occur. In this nationwide study, we analyzed clinical manifestations children diagnosed with acute respiratory syndrome coronavirus 2 to identify high-risk groups for and compared the features between Delta- Omicron-dominant periods. Methods: Data were retrieved from National Health Insurance Service (NHIS) database merged Korea Disease Control Prevention Agency-COVID-19-NHIS...
Expansion of the single sequence type 3 (ST3) was associated with a high macrolide resistance rate among Mycoplasma pneumoniae in Korea during 2014-2016 epidemic. This study investigates and genetic diversity subsequent epidemic M. pneumonia 2019-2020.The culture for developed from 1228 respiratory samples collected children four hospitals between January 2019 2020. Determination multilocus typing analysis were performed on isolates. eBURST applied to estimate relationships strains assign...
Considering the mild degree of coronavirus disease 2019 (COVID-19) in children and enormous stress caused by isolation unfamiliar places, policies requiring mandatory at medical facilities should be reevaluated especially given impact pandemic on availability hospital beds.In this study, we assessed usefulness facility transmissibility severe acute respiratory syndrome 2 infected to uninfected caregivers units a residential treatment center Seoul during August-November 2020.Fifty-three were...
The risk of severe outcomes with acute respiratory syndrome coronavirus 2 (SARS-CoV-2) delta variant remains low in children and adolescents, but less is known about its effect on the SARS-CoV-2-naïve population. This study evaluated clinical manifestations factors for moderate-to-critical disease 2019 (COVID-19) mostly adolescents 2021.This multicenter retrospective included patients aged 0-18 years who were hospitalized COVID-19 at 8 referring hospitals South Korea during...
Yersinia pseudotuberculosis is known to cause fever, gastroenteritis, or acute kidney injury (AKI). There have been several Y. infection outbreaks date associated with ingestion of contaminated food unsterile water. While this disease was considered practically eradicated the improvement in public health, we encountered cases AKI infection.We retrospectively collected data from medical records patients suspected who visited Seoul National University Children's Hospital 2017.There were nine...
ObjectivesIn Korea, the National Immunization Program provided trivalent inactivated influenza vaccines (IIV3) to all children aged 6–59 months during 2017–2018 season. In this study, we aimed evaluate vaccine effectiveness (VE) of IIV3 in season.MethodsChildren who were tested for their acute respiratory illness four hospitals season included. We estimated VE by test-negative case-control design based on rapid diagnostic test (RIDT) or reverse transcription polymerase chain reaction...
Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been acknowledged as an effective mean of preventing infection and hospitalization. However, the emergence highly transmissible SARS-CoV-2 variants concern (VOCs) led to substantial increase in infections among children adolescents. Vaccine-induced immunity longevity have not well defined this population. Therefore, we aimed analyze humoral cellular immune responses ancestral after two shots BNT162b2 vaccine...
Abstract Nosocomial transmission of COVID-19 among immunocompromised hosts can have a serious impact on severity, underlying disease progression and SARS-CoV-2 to other patients healthcare workers within hospitals. We experienced nosocomial outbreak in the setting daycare unit for paediatric young adult cancer patients. Between 9 18 November 2020, 473 individuals (181 patients, 247 caregivers/siblings 45 staff members) were exposed index case, who was nursing staff. Among them, three four...
Purpose: Common human coronaviruses (HCoVs) are relatively understudied due to the mild nature of HCoV infection. Given lack local epidemiology data on common HCoVs, we aimed describe clinical and epidemiological characteristics HCoVs in children. Methods: Respiratory viral test results from 9,589 respiratory samples Seoul National University Children's Hospital were analyzed January 2015 December 2019. Viral detection was done by multiplex reverse transcription polymerase chain reaction....
Azathioprine is commonly used as immunosuppressive therapy for various inflammatory diseases including chronic glomerulonephritis. Myelosuppression a common side effect of azathioprine, resulting in the need dose reduction. However, severe pancytopenia or alopecia not often encountered. Here, we report case myelosuppression, and totalis that occurred after azathioprine treatment patient with IgA nephropathy. A 10-year-old boy nephropathy was treated oral deflazacort later azathioprine. After...
BackgroundNasopharyngeal (NP) colonization with Streptococcus pneumoniae and non-typeable Haemophilus influenzae (NTHi) is common in children, may evolve as the source of invasive infections. In Korea, pneumococcal conjugate vaccines (PCVs) were introduced >10 years ago, enabling authors to study effect vaccine preventing carriage.MethodsNP swabs taken a household survey was conducted at daycare centres located different regions Korea 2014 2019. Pneumococcal serotypes identified using...
Abstract Background: Compared to influenza virus and respiratory syncytial virus, common human coronaviruses (HCoVs) are relatively understudied due the mild nature of HCoV infection. Given lack local epidemiology data on HCoVs in Korea, we aimed describe epidemiological characteristics HCoVs. Methods: Respiratory viral test results from more than 67,000 samples two sources, Korea Influenza Viruses Surveillance System (KINRESS, N=58,253) Seoul National University Children’s Hospital (SNUCH,...
Although various childhood illnesses are known to influence growth status, the impact of urinary tract infections (UTI) on subsequent remains unclear. This study was conducted examine association between UTI during infancy and status at 30-36 months.Nationwide population-based matched cohort done using data from Korean National Health Insurance System (NHIS) Screening Program for Infants Children (NHSPIC) January 2018 December 2020. Height weight standard deviation scores (SDSs) fourth...
Eikenella corrodens rarely causes invasive head and neck infections in immunocompetent children.We report a case of epidural abscess caused by E. previously healthy 13-year-old boy who presented with fever, headache, vomiting.On physical examination upon admission, there was no stiffness, but discharge from the right ear observed.Brain magnetic resonance imaging (MRI) revealed approximately 4.5-cm-sized empyema on temporal lobe as well bilateral ethmoid sphenoid sinusitis, mastoiditis,...
We aimed to investigate the microbiologic characteristics of nonbaumannii Acinetobacter calcoaceticus-baumannii (NB-ACB) complex isolated from Korean children. Blood isolates ACB complexes were collected in three referring hospitals during 2015-2020. Genomic DNA was sequenced using a Nanopore sequencing platform, and assembled contigs used for antimicrobial resistance (AMR) gene detection. Of 55 complexes, 18 (32.7%) identified as NB-ACB complexes: A. nosocomialis (n=9), pittii (n=7),...
Abstract Background Human adenovirus (HAdV) is a common cause of respiratory tract infection (RTI) and clinical presentation varies by serotype. Serotypes 7 55 caused severe pneumonia in children during the early 2000s soldiers from 2014 to 2018, respectively, South Korea. Recent data for epidemiologic features HAdV Korean are scarce. Methods Nasal aspirates were collected patients aged 18 years or younger with suspected RTIs at Seoul National University Children's Hospital 2008 2019....