A5053793499- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Pediatric Urology and Nephrology Studies
- Healthcare Education and Workforce Issues
- Psychosocial Factors Impacting Youth
- Education and Learning Interventions
- Health and Well-being Studies
- Acute Kidney Injury Research
- Complement system in diseases
- Systemic Lupus Erythematosus Research
- Aging and Gerontology Research
- Optimism, Hope, and Well-being
- Ion Transport and Channel Regulation
- Health and Wellbeing Research
- Kidney Stones and Urolithiasis Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Muscle and Compartmental Disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Vascular anomalies and interventions
- Gout, Hyperuricemia, Uric Acid
- Psychological Well-being and Life Satisfaction
- Psychological and Temporal Perspectives Research
- Parvovirus B19 Infection Studies
- Urinary Tract Infections Management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
Hallym University Sacred Heart Hospital
2020-2024
Korea University
2024
Samsung (South Korea)
2024
Seoul National University
2019-2022
Hallym University
2021
Seoul National University Children's Hospital
2017-2020
Seoul National University Hospital
2018-2020
Chungnam National University Hospital
2019
Pusan National University Yangsan Hospital
2019
Asan Medical Center
2019
Primary distal renal tubular acidosis (dRTA) in children is a rare genetic disorder, and three causative mutated genes have been identified: SLC4A1, ATP6V1B1, ATP6V0A4. We analyzed the prevalence phenotypic differences of mutations with dRTA.A total 17 dRTA were enrolled study. All patients underwent testing for all candidate genes.Pathogenic mutations, including six novel detected 15 (88.2%) patients: dominant SLC4A1 ten (58.8%) patients, recessive ATP6V0A4 (17.6%) ATP6V1B1 two (11.8%)...
Acute kidney injury (AKI) is common in critically ill children, and associated with increased mortality long-term renal sequelae. The definition of pediatric AKI was standardized based on elevation serum creatinine levels or decrease urine output; accordingly, epidemiological studies have ensued. Although new biomarkers appear to detect earlier predict prognosis more accurately than traditional markers, they are not frequently used clinical setting. There no validated pharmacological...
Abstract The genotype–phenotype correlation of the X-linked Alport syndrome (XLAS) has been well elucidated in males, whereas it remains unclear females. In this multicenter retrospective study, we analyzed 216 Korean patients (male:female = 130:86) with XLAS between 2000 and 2021. were divided into three groups according to their genotypes: non-truncating group, abnormal splicing truncating group. male patients, approximately 60% developed kidney failure at median age 25.0 years, survival...
We propose in this paper an efficient FALCON accelerator called EFX based on a HW/SW co-design where is post-quantum cryptographic (PQC) scheme tailored as digital signature algorithm (DSA). Our findings reveal that exhibits unique characteristics and structures which distinguish it from other PQC-DSAs. A key finding that, unlike its counterparts, doesn't prioritize single, time-consuming task; instead, processes variety of tasks with comparable execution times. Consequently, the...
Nephrotic syndrome (NS) is the most common glomerulopathy in children. Acute kidney injury (AKI) a complication of NS, caused by severe intravascular volume depletion, acute tubular necrosis, interstitial nephritis, or progression NS. However, incidence and risk factors childhood-onset NS Korea are unclear. Therefore, we studied incidence, causes, AKI hospitalized Korean patients with NS.We conducted retrospective review who were admitted to our center from January 2015 July 2017. Patients...
Galloway–Mowat syndrome (GAMOS) is a rare hereditary renal–neurological disease characterized by early-onset steroid-resistant nephrotic in combination with microcephaly and brain anomalies. Recently, novel causative mutations for this have been identified the genes encoding four KEOPS subunits: OSGEP, TP53RK, TPRKB, LAGE3. We detected homozygous TP53RK mutation (NM_033550, c.194A > T, p.Lys65Met) using whole exome sequencing familial case of GAMOS three affected siblings. All patients...
Menkes disease (MD) is a rare X-linked hereditary multisystemic disorder that caused by dysfunction of copper metabolism. Patients with MD typically present progressive neurodegeneration, some connective tissue abnormalities, and characteristic "kinky" hair. In addition, various types urological complications are frequent in because underlying abnormalities. this study, we studied the clinical features outcomes MD, focusing on complications.A total 14 unrelated Korean pediatric patients (13...
Purpose To establish age/sex-specific reference intervals for serum uric acid and to examine the associations between level metabolic syndrome (MetS) its components in Korean children adolescents. Methods We analyzed data 1,349 subjects aged 10 19 years from Korea National Health Nutrition Examination Survey 2016–2017. Results The mean levels were 5.9±1.3 mg/dL (interquartile range, 5.0–6.8 mg/dL) males 4.6±0.9 3.9–5.2 females. increased significantly 10–13 of age males, but not overall...
Rituximab (RTX) can be used as a rescue therapy for steroid-dependent nephrotic syndrome (SDNS). However, the efficacy and safety of long-term, repeated use RTX are not established. This study was conducted to assess treatment in children.Eighteen consecutive child patients with SDNS who were treated three or more cycles one year longer recruited, their medical records retrospectively reviewed.The followed 4.7 ± 1.9 years received 5.2 2.3 over 2.8 1.1 years. Approximately 70% additional...
D-penicillamine has been reported to cause antineutrophil cytoplasmic antibody (ANCA)associated vasculitis presenting as rapidly progressive glomerulonephritis or pulmonaryrenal syndrome mostly in adults.We report a pediatric case of induced ANCA-associated that manifests pulmonary-renal with mild renal manifestation.A 13-year-old girl who taking for five years under the diagnosis Wilson disease visited emergency room because hemoptysis and dyspnea.She had diffuse pulmonary hemorrhage,...
Background: Post-transplant lymphoproliferative disease (PTLD) is one of the major complications organ transplantation, especially in children with Epstein-Barr virus (EBV) viremia (EV).We performed a retrospective study to evaluate risk factors for PTLD EV.Methods: Among 199 pediatric kidney transplantation (KT) recipients at our center from January 2001 October 2015, records those EBV viral loads > 1,000 copies/mL and/ or were reviewed.Results: Diagnosis was made seven patients (PTLD...
Immunoglobulin A nephropathy (IgAN) is one of the most common primary glomerulopathies diagnosed in children and adolescents. This study aimed to evaluate clinical features outcomes pediatric IgAN over last 30 years. Patients who were before age 18 at 20 centers Korea evaluated retrospectively. Of 1154 patients (768 males, 386 females) with a median follow-up 5 years, 5.6% (n = 65) progressed stage 3–5 chronic kidney disease (CKD). The 10- 20-year CKD-free survival rates 91.2% 75.6%,...
Hematuria is a relatively common condition among school-aged children. Because international guidelines for asymptomatic hematuria in children are unavailable, developing practical the diagnosis and management of based on scientific evidence while considering real-world practice settings, values, patient physician preferences essential. The Korean Society Pediatric Nephrology developed clinical to address key questions regarding
Adolescent Build Plotting on Body Composition Chart and the Type of Diabetes MellitusAlthough prevalence type 2 diabetes is increasing, there are cases difficult to categorize into certain in pediatric diabetic patients.The aims this study were detect choose a proper treatment modality for atypical mellitus, using body composition chart.We conducted retrospective from August 2005 2012 with patients who visited Konkuk University Medical Center, diagnosed mellitus.The medical records reviewed...
The most common type of refractory hypertension found in children is secondary hypertension, which a potentially curable disease. Reninoma, renin-secreting juxtaglomerular cell tumor, rare cause severe that usually diagnosed adolescents and young adults. Surgical resection the tumor completely cures patients with reninoma. typical clinical presentation reninoma includes hypokalemia, metabolic alkalosis, features to increased activation renin-angiotensin system without renal artery stenosis....
Yersinia pseudotuberculosis is known to cause fever, gastroenteritis, or acute kidney injury (AKI). There have been several Y. infection outbreaks date associated with ingestion of contaminated food unsterile water. While this disease was considered practically eradicated the improvement in public health, we encountered cases AKI infection.We retrospectively collected data from medical records patients suspected who visited Seoul National University Children's Hospital 2017.There were nine...
Acute kidney injury (AKI) is characterized by abrupt deterioration of renal function, and its diagnosis relies on creatinine measurements urine output. AKI associated with higher morbidity mortality, a risk factor for development chronic disease. There no proven medication AKI. Therefore, prevention early detection are important. Physicians should be aware the factors monitor function in high-risk patients. Management includes optimization volume status perfusion, avoidance nephrotoxic...
Obesity and obesity-related disease are becoming serious global issues. The incidence of obesity type 2 diabetes has increased in children adolescents. Type is a chronic that difficult to treat, the accurate assessment increasingly important. excessive accumulation fat causes insulin resistance, body composition analyses can help physicians evaluate levels. Although previous studies have shown achievement complete remission after focused improvement lifestyle habits, there few cases...
Abstract Giant cell hepatitis (GCH) with autoimmune hemolytic anemia (AHA) is a very rare disease characterized by early onset and severe clinical manifestations, including immune cholestasis. The prognosis poor despite aggressive immunosuppressive therapy. We report here the first case of GCH AHA in East Asia. A 2‐month‐old boy was admitted jaundice. Blood test indicated abnormal liver function low hemoglobin. Direct Coombs several autoantibodies associated were positive, biopsy consistent...