A5036871510- Neuroblastoma Research and Treatments
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Glioma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Sarcoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Testicular diseases and treatments
- Congenital Diaphragmatic Hernia Studies
- Blood disorders and treatments
- Histiocytic Disorders and Treatments
- Vascular Malformations and Hemangiomas
- Viral-associated cancers and disorders
- Hematopoietic Stem Cell Transplantation
- Neurofibromatosis and Schwannoma Cases
- Chromatin Remodeling and Cancer
- Metabolism and Genetic Disorders
- Neurological Complications and Syndromes
- Parvovirus B19 Infection Studies
- Global Cancer Incidence and Screening
- Spinal Hematomas and Complications
- Hepatitis B Virus Studies
- Gestational Trophoblastic Disease Studies
- Lymphatic Disorders and Treatments
- Enterobacteriaceae and Cronobacter Research
Chuncheon Sacred Heart Hospital
2017-2018
Hallym University
2017-2018
National Cancer Center
2011-2017
Cancer Research Institute
2013-2017
National Cancer Center
2015
Seoul National University Hospital
2009-2014
Seoul National University
2006-2013
National University College
2013
Cancer Research Institute of the Slovak Academy of Sciences
2013
New Generation University College
2013
Background The nationwide statistical analysis of hematologic malignancies in Korea has not been reported yet. Methods Central Cancer Registry and the Korean Society Hematology jointly investigated domestic incidence rates prevalence occurred between 1999 2008, analyzed survival patients who were diagnosed 1993 2008. Data from to 2008 obtained National Incidence base. crude rates, age-specific age-standardized annual percentage change incidence, 1999-2008 calculated. Survival for 1993-2008...
Background. The benefits of proton beam craniospinal irradiation (PrBCSI) in children have been extensively reported dosimetric studies. However, there is limited clinical evidence supporting the use PrBCSI. We compared acute toxicity PrBCSI relative to that conventional photon CSI (PhBCSI) with brain tumours.Material and methods. prospectively evaluated haematological gastrointestinal toxicities 30 patients who underwent between April 2008 December 2012. As a reference group, we...
We report a very rare case of sellar and suprasellar atypical teratoid rhabdoid tumor (ATRT) in 42-year-old female patient. The was removed subtotally with transsphenoidal approach. Histopathologic study showed cells prominent nucleoli abundant cytoplasm. Immunohistochemistry for INI1 completely negative the cells, consistent ATRT. After surgery, she received radiotherapy including spinal irradiation proton beam therapy subsequent chemotherapy, no evidence recurrence more than 2 years. Up to...
Successful Treatment of Primary Central Nervous System Lymphoma without Irradiation in Children: Single Center ExperiencePrimary CNS lymphoma (PCNSL) is a very uncommon disease children, and usually treated by chemotherapy, combined with focal or craniospinal radiotherapy (RT).However, adverse effects RT are concern.We evaluated the outcomes childhood PCNSL, systemic intrathecal but RT.For fifteen years, six patients among 175 non-Hodgkin were diagnosed as PCNSL Seoul National University...
Sinusoidal obstruction syndrome (SOS) is a serious complication of hematopoietic stem cell transplantation (HSCT), with mortality rate up to 90%. We report our experience on the use defibrotide for SOS prophylaxis in HSCT.We retrospectively reviewed data 49 patients who received as during course HSCT at National Cancer Center, Goyang, Korea, between August 2005 and July 2008.Thirty-four (69.4%) were classified high-risk group developing SOS. Defibrotide was well-tolerated, without any grade...
Few studies have addressed gonadal and sexual dysfunctions in childhood cancer survivors. We evaluated the prevalence rates risk factors for failure among adolescent/young adult survivors their function.Subjects were aged 15-29 years who had completed therapy more than 2 ago. Demographic medical characteristics obtained from patients' records. In addition, hormonal evaluation semen analysis performed function was via questionnaire.The study included 105 (57 males, 48 females), of which 61...
Purpose To establish age/sex-specific reference intervals for serum uric acid and to examine the associations between level metabolic syndrome (MetS) its components in Korean children adolescents. Methods We analyzed data 1,349 subjects aged 10 19 years from Korea National Health Nutrition Examination Survey 2016–2017. Results The mean levels were 5.9±1.3 mg/dL (interquartile range, 5.0–6.8 mg/dL) males 4.6±0.9 3.9–5.2 females. increased significantly 10–13 of age males, but not overall...
Patients with Ewing sarcoma family of tumors (ESFT) who are resistant even to salvage chemotherapy, have dismal prognoses and few therapeutic options. Because the docetaxel/irinotecan (DI) combination has not been previously evaluated in ESFT, we prospectively its use patients recurrent or refractory ESFT.Patients aged <30 years failed ≥ third-line therapy, were eligible. They received docetaxel 100 mg/m(2) intravenously on day 1, irinotecan 80 days 1 8, a 21-day cycle up 15 cycles until...
This retrospective study investigated the clinical characteristics and outcomes of second malignant neoplasms (SMNs) in survivors childhood cancer from multiple institutions Korea.A total 102 patients 11 who developed SMN after treatment between 1998 2011 were retrospectively enrolled.The most common primary (PMNs) central nervous system (CNS) tumors (n = 17), followed by acute lymphoblastic leukemia 16), non-Hodgkin lymphoma 13), osteosarcoma 12).The SMNs therapy-related myeloid (t-MNs;...
Background: Pleuropulmonary blastoma (PPB) is a rare and aggressive intrathoracic neoplasm that associated with other dysplastic or neoplastic conditions. The prognosis, especially of type II (cystic solid) III (solid) PPB, poor. High-dose chemotherapy (HDC) hematopoietic stem cell transplantation (HSCT) have been attempted to improve survival rates. We report the development follicular thyroid carcinoma in girl who was treated at young age for PPB. Summary: A 23-month-old evaluated clinical...
Abstract Although the varied neurotoxicity of intrathecal ( IT ) chemotherapy for treatment childhood acute leukemia is well known, most are related to transient post‐puncture headache, drug‐induced arachnoiditis, or leukoencephalopathy after methotrexate cytarabine. Cerebral vasospasm leading infarct very uncommon in children. Reported herein a rare case diffuse cerebral with subsequent cytarabine 7‐year‐old boy lymphoblastic leukemia, who successfully recovered supportive management, and...
Malignant peripheral nerve sheath tumor (MPNST) is a rare soft tissue malignancy usually found in patients with neurofibromatosis type 1 (NF1) poor outcome. Although MPNST can be any part of the body including head and neck or extremities, intrathoracic without NF1 uncommon, especially children adolescents. Reported herein case huge 16-year-old girl NF1, brief review literature.
Relapse is the major cause of treatment failure in acute lymphoblastic leukemia (ALL), yet there no established for relapsed ALL.To improve induction remission rate, we modified dose idarubicin original Children's Cancer Group (CCG)-1884 protocol, and retrospectively compared results.Twenty-eight patients diagnosed with ALL received chemotherapy according to CCG-1884 protocol.Complete (CR) rate all after was 57%.The 10 mg/m 2 /week group showed CR 74%, 22% 12.5 (p=0.010).Remission due...
Langerhans cell histiocytosis (LCH) has diverse clinical manifestations, including intracranial mass lesions. We report a case of LCH that manifested as suprasellar mass, and initially misdiagnosed germ tumor. A 29-year-old woman presented with polyuria, polydipsia amenorrhea. Laboratory findings revealed hypopituitarism central diabetes insipidus, pineal were observed on magnetic resonance imaging. Under the impression tumor, patient was treated tumor chemotherapy (cisplatin etoposide)...
Background: Hodgkin's lymphoma (HL) constitutes 10%-20% of all malignant lymphomas and has a high cure rate (5-year survival, around 90%).Recently, interest increased concerning preventing secondary complications (secondary cancer, endocrine disorders) in long-term survivors.We aimed to study the epidemiologic features therapeutic outcomes HL children, adolescents, young adults Korea.Methods: We performed multicenter, retrospective 224 patients aged < 25 years diagnosed with at 22...
Background: The bone marrow (BM) findingd on day 7 of induction chemotherapy is one major prognostic factors for patients with acute lymphoblastic leukemia (ALL). M3 (blast ＞25% BM examination) associated lower survival rates, compared the M1 ＜5%) or M2 5∼25%) marrow. Herein, we analyzed effect augmented post-induction in who have high-risk ALL examination. Methods: We were diagnosed and they received modified Children's Cancer Group (CCG)-1882 between January 1996 October 2005 at Seoul...
Abstract Interferon consensus sequence binding protein (ICSBP) is a transcription factor induced by interferon gamma (IFN-γ) and member of the regulatory (IRF) family. ICSBP predominantly expressed in hematopoietic cells regulates immune response cell growth differentiation. However, little known about its function non-hematopoietic cells. Here we show novel for epithelial to mesenchymal transition (EMT)-like phenomena (ELP), motility, invasion human osteosarcoma lines, including U2OS IFN-γ...