A5008228126- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Power Line Communications and Noise
- Advanced Radiotherapy Techniques
- Cancer, Hypoxia, and Metabolism
- Lymphoma Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Lung Cancer Treatments and Mutations
- CNS Lymphoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Sarcoma Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Bone Tumor Diagnosis and Treatments
- Ocular Oncology and Treatments
- Protein Degradation and Inhibitors
- Neuroblastoma Research and Treatments
- Electromagnetic Compatibility and Noise Suppression
- Vascular Malformations Diagnosis and Treatment
- Advanced MIMO Systems Optimization
- Neurofibromatosis and Schwannoma Cases
- Chromatin Remodeling and Cancer
Seoul National University Hospital
2015-2025
Seoul National University
2015-2024
National University College
2002-2022
New Generation University College
2002-2022
Cancer Research Institute of the Slovak Academy of Sciences
2019
Korea Testing Laboratory
2019
Texas Instruments (United States)
2009-2018
Seoul National University Children's Hospital
2006-2016
Sungkyunkwan University
2016
Samsung (South Korea)
2016
Tumor hypoxia and aerobic glycolysis are well-known resistance factors for anticancer therapies. Here, we demonstrate that tumor-associated macrophages (TAM) enhance tumor in mice subcutaneous tumors patients with non-small cell lung cancer (NSCLC). We found a strong correlation between CD68 TAM immunostaining PET 18fluoro-deoxyglucose (FDG) uptake 98 matched of NSCLC. also observed significant glycolytic gene signatures 513 NSCLC from The Cancer Genome Atlas database. secreted TNFα to...
Abstract BACKGROUND: This study was undertaken to evaluate the prognostic value of quantitative metabolic parameters in [ 18 F]2‐fluoro‐2‐deoxyglucose (FDG)‐positron emission tomography (PET) for diffuse large B cell lymphoma (DLBCL). METHODS: A total 140 DLBCL patients underwent FDG‐PET scans before rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R‐CHOP) chemotherapy. The maximal standardized uptake (SUV max ) lesion glycolysis (TLG) were calculated, with margin...
A Smart Grid intelligently monitors and controls energy flows in an electric grid. Having up-to-date distributed readings of grid conditions helps utilities efficiently scale generation up or down to meet demand. Narrowband powerline communication (PLC) systems can provide these from subscribers the local utility over existing power lines. key challenge PLC is overcoming additive non-Gaussian noise. In this paper, we propose use a cyclostationary model for dominant component The...
To explore the role of dynamic contrast material-enhanced magnetic resonance (MR) imaging in differentiation true progression from pseudoprogression patients with glioblastoma on basis findings entirely newly developed or enlarged enhancing lesions after concurrent radiation therapy and chemotherapy temozolomide to evaluate diagnostic performance quantitative pharmacokinetic parameters obtained at contrast-enhanced MR imaging, such as volume transfer constant (K(trans)), extravascular...
We aimed to investigate the feasibility of machine learning (ML) algorithm distinguish pseudoprogression (PsPD) from progression (PD) in patients with glioblastoma (GBM). recruited diagnosed as primary GBM who received gross total resection (GTR) and concurrent chemoradiotherapy two institutions April 2010 2017 presented suspicious contrast-enhanced lesion on brain magnetic resonance imaging (MRI) during follow-up. Patients were allocated training (N = 59) testing 19) datasets, respectively....
Significance Here, we are reporting our findings that hypoxia-inducible factor 1 (HIF-1) activation in monocytes promotes neovascularization matrigel and improves blood flow hindlimb ischemia through production of vascular endothelial growth S100A8. We found HIF-1 regulates S100A8 expression specifically isolated from unique strain transgenic mice targeting HIF pathways.
Objective:The purpose of this study was to differentiate true progression from pseudoprogression glioblastomas treated with concurrent chemoradiotherapy (CCRT) temozolomide (TMZ) by using histogram analysis apparent diffusion coefficient (ADC) and normalized cerebral blood volume (nCBV) maps.Materials Methods: Twenty patients histopathologically proven glioblastoma who had received CCRT TMZ underwent perfusion-weighted imaging diffusion-weighted (b = 0, 1000 sec/mm 2 ).The corresponding nCBV...
Object Glioblastoma is the most common primary malignant brain tumor; however, glioblastoma in children less than adults, and little known about its clinical outcome children. The authors evaluated long-term of Methods Twenty-seven were confirmed to have harbored a between 1985 2007. features treatment outcomes reviewed retrospectively. All patients underwent resection; complete resection was performed 12 (44%), subtotal biopsy 3 (11%). Twenty-four (89%) had radiation therapy, 14 (52%)...
Several studies have shown solid evidence for the potential value of targeting epidermal growth factor receptor (EGFR) signaling to enhance antitumor activity radiation. However, therapeutic resistance has emerged as an important clinical issue. Here, we investigated whether strategies EGFR-associated downstream would radiosensitize a panel non-small cell lung cancer lines. Inhibition K-RAS using RNA interference attenuated and increased radiosensitivity A549 H460 cells, whereas inhibition...
// Chul-Kee Park 1,7 , Se-Hoon Lee 2,8 Ji Young Kim Ja Eun Tae Min Soon-Tae 3,7 Seung Hong Choi 4,7 Sung-Hye 5,9 Il Han 6,8 1 Department of Neurosurgery, Seoul National University College Medicine, Hospital, Seoul, Korea 2 Internal 3 Neurology, 4 Radiology, 5 Pathology, 6 Radiation Oncology, 7 Biomedical Research Institute, 8 Cancer 9 Neuroscience Correspondence: email: Lee, Keywords : Glioblastoma, hTERT, promoter mutation, hTERT expression, single nucleotide polymorphism, rs2853669...
This study aimed to evaluate the long-term efficacy and complication of radiotherapy for benign soft tissue tumors. Five cases tumors (two plexiform neurofibromas, two juvenile nasopharyngeal angiofibromas, one cavernous sinus hemangioma) who underwent were enrolled. All patients had at least 10 years follow-up. The median follow-up duration was 12 (range, 27). Three incomplete excision prior radiotherapy. Radiation doses either 54 Gy in 30 fractions or 50.4 28 (1.8 per fraction). Every...
PRIME (PoweRline Intelligent Metering Evolution) is a narrowband Power Line Communications (PLC) technology targeted for use in smart metering applications. It standardized as part of international Recommendations ITU-T G.9955 and G.9956, there are currently number deployments by utilities different markets which it cost-effective, technically proven solution. This paper continuation two previous ones presented the first second SmartGridComm Conferences, background status were discussed,...
In modern wireless communications, systems that send a common information stream (called multicasting systems) are widely needed for distributing content such as television or radio. this paper, the multiple antenna physical layer channel is considered, in which message simultaneously transmitted to single-antenna users. To achieve capacity of set-up, covariance matrix transmit signal vector needs be determined maximize smallest maximum achievable rate among all we develop simple successive...
To evaluate the mechanism of development therapeutic resistance after temozolomide treatment, we focused on changes in O(6)-methylguanine DNA methyltransferase (MGMT) and mismatch repair (MMR) between initial recurrent glioblastomas. Tissue samples obtained from 24 paired histologically confirmed adult glioblastoma patients who were initially treated with used for MGMT MMR gene promoter methylation status protein expression analysis using methylation-specific multiplex ligation probe...