A5019048136- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Cancer and Skin Lesions
- Sarcoma Diagnosis and Treatment
- Cutaneous lymphoproliferative disorders research
- Lung Cancer Treatments and Mutations
- Nail Diseases and Treatments
- Immune Cell Function and Interaction
- Dermatological diseases and infestations
- Cancer Research and Treatments
- Immunotherapy and Immune Responses
- CNS Lymphoma Diagnosis and Treatment
- Virus-based gene therapy research
- Histiocytic Disorders and Treatments
- Nonmelanoma Skin Cancer Studies
- Vascular Tumors and Angiosarcomas
- RNA modifications and cancer
- Genetic and rare skin diseases.
- Eosinophilic Disorders and Syndromes
- Contact Dermatitis and Allergies
- Lung Cancer Research Studies
- Cancer-related molecular mechanisms research
- Plant Physiology and Cultivation Studies
- T-cell and Retrovirus Studies
- RNA Interference and Gene Delivery
Hallym University
2015-2024
Kangdong Sacred Heart Hospital
2015-2024
Korea Forest Service
2013-2024
SK Group (South Korea)
2024
Nune Eye Hospital
2020-2024
Catholic Kwandong University
2020-2024
Immunité et Cancer
2003-2023
Kyoto University
2012-2022
Daewon Pharm (South Korea)
2021
Seoul National University Hospital
2010-2020
Abstract Background Tumor-associated macrophages (TAM) play an important role in tumor microenvironment. Particularly, M2 contribute to progression, depending on the expression of NF-κB. Tumor-derived exosomes can modulate microenvironment by transferring miRNAs immune cells. Epigallocatechin gallate (EGCG) has well known anti-tumor effects; however, no data are available influence EGCG communication with cancer cells and TAM. Methods Murine breast cell lines, 4T1, was used for vivo ex...
Hepatitis B virus X protein (HBx) is closely involved in the development of hepatocellular carcinoma, a highly vascularized solid tumor. Here we show that HBx increases transcriptional activity and level hypoxia-inducible factor-1alpha (HIF-1alpha) under both normoxic hypoxic conditions, it also stimulates angiogenesis. directly interacted with bHLH/PAS domain HIF-1alpha but not von Hippel-Lindau (pVHL). decreased binding pVHL to prevented ubiquitin-dependent degradation HIF-1alpha. In...
Abstract BACKGROUND: This study was undertaken to evaluate the prognostic value of quantitative metabolic parameters in [ 18 F]2‐fluoro‐2‐deoxyglucose (FDG)‐positron emission tomography (PET) for diffuse large B cell lymphoma (DLBCL). METHODS: A total 140 DLBCL patients underwent FDG‐PET scans before rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R‐CHOP) chemotherapy. The maximal standardized uptake (SUV max ) lesion glycolysis (TLG) were calculated, with margin...
Aims To investigate the clinicopathological characteristics of programmed cell death ligand 1 ( PD ‐L1) and ‐1) expression in tumour microenvironments diffuse large B lymphoma DLBCL ). Methods results Tumour tissues from 126 patients were immunostained for ‐L1 ‐1. The by cells and/or tumour‐infiltrating immune (mainly macrophages) was evaluated, number ‐1 + assessed. observed 61.1% s, with a weak intensity 29.4%, moderate 21.4% strong 10.3% cases. Strong associated significantly presence...
Programmed cell death (PD)-1/PD-1 ligand-1 (PD-L1)-targeted therapy has emerged as a promising therapeutic strategy for lung cancer. However, whether EML4-ALK regulates PD-L1 expression in cancer remains unknown. A total of 532 pulmonary adenocarcinomas (pADCs), including 58 ALK-translocated tumors, were immunohistochemically evaluated and PD-1. H23 (EGFRWild-typeEML4-ALK−PD-L1Low) H2228 (EGFRWild-typeEML4-ALK+PD-L1High) cells transfected with or ALK short interfering RNAs used to...
It is well known that some trace elements such as zinc and copper play a significant role in many forms of hair loss. However, the effect pathogenesis loss still unknown.The purpose this study to evaluate status each four types loss.A was carried out with 30 health controls 312 patients who were diagnosed alopecia areata (AA), male pattern loss, female telogen effluvium (TE) (2008 2011; Hallym University Kangdong Sacred Heart Hospital). Zinc serum concentrations evaluated between patients.In...
Tumor-associated macrophages (TAMs) and regulatory T-cells (Tregs) play an important role in the tumor microenvironment. Here, we investigated prognostic implications of TAMs Tregs 165 diffuse large B-cell lymphomas (DLBCLs) using immunohistochemistry. Survival analysis was performed among 109 DLBCLs treated with rituximab, cyclophosphamide, doxorubicin, vincristine prednisone (R-CHOP). An increase CD68 (+) cells related to improved overall survival (OS) (p = 0.033). By contrast, increased...
Walnut anthracnose caused by Colletotrichum gloeosporioides is a deleterious disease that severely affects the production of walnut (Juglans regia L.). The aim this study was to assess antifungal and growth promotion activities Bacillus velezensis CE 100 as an alternative chemical use in production. crude enzyme from B. exhibited chitinase, protease, β-l,3-glucanase activity degraded cell wall C. gloeosporioides, causing inhibition spore germination mycelial 99.3% 33.6% at µL/mL,...
Breast cancer is the most common type of seen in women western countries. Thus, diagnostic modalities sensitive to early-stage breast are needed. Antibody-based array platforms a data-driven type, which expected facilitate more rapid and detection novel biomarkers, have emerged as direct, means for profiling cancer-specific signatures using small samples. In line with this concept, our group constructed an antibody bead panel 35 analytes that were selected during discovery step. This study...
Topical corticosteroids (TCS) are the first-line agents for treatment of atopic dermatitis (AD). However, a vague phobia concerning use TCS exists among parents children with AD because misinformation, and studies on subject insufficient.To assess current state steroid in Korea to investigate importance education its reduction.By using structured questionnaire, 126 (22.2% fathers, 77.8% mothers) were interviewed. After questionnaire administration, all participants educated about...
BACKGROUNDThe aim of study was to determine the relative frequency malignant lymphoma according World Health Organization (WHO) classification in Korea.METHODSA total 3,998 cases diagnosed at 31 institutes between 2005 and 2006 were enrolled. Information including age, gender, pathologic diagnosis, site involvement immunophenotypes obtained.RESULTSThe non-Hodgkin (NHL) Hodgkin (HL) 95.4% 4.6%, respectively. B-cell lymphomas accounted for 77.6% all NHL, while T/natural killer (T/NK)-cell...
Scabies is a contagious skin infestation characterized clinically by nocturnal pruritus, visible burrows and contagiousness. Dermoscopy has been suggested as an alternative for diagnosing scabies. But, there have few well-designed studies evaluating the diagnostic accuracy of dermoscopy.We tried to confirm dermoscopy We also demonstrate specific circumstances in which dermoscopic identification mites ("with dermoscopy") more useful scabies, identify clinical findings that could be used...
Several studies have reported a higher prevalence of chronic hepatitis C virus (HCV) infection in patients with B‐cell non‐Hodgkin's lymphoma and suggested pathogenic role for HCV, but on B (HBV) are limited. To determine the association between HBV lymphoma, we performed case‐control study Korea, endemic area. We recruited 222 newly diagnosed at Seoul National University Hospital January 1997 December 1998 as cases. Four age‐ sex‐matched controls were selected each case, control groups...
Abstract Introduction Adenine nucleotide translocator (ANT) 2 is highly expressed in proliferative cells, and ANT2 induction cancer cells known to be directly associated with glycolytic metabolisms carcinogenesis. In addition, repression results the growth arrest of human implying that a candidate for therapy based on molecular targeting. Methods We utilized an ANT2-specific RNA interference approach inhibit expression evaluating its antitumor effect vitro vivo . Specifically, investigate...
Exosomes are small membrane vesicles secreted from various types of cells. Tumor-derived exosomes contain MHC class I molecules and tumor-specific antigens, receiving attention as a potential cancer vaccine. For induction efficient anti-tumor immunity, CD4+ helper T cells required, which recognize appropriate II-peptide complexes. In this study, we have established an II molecule-expressing B16F1 murine melanoma cell line (B16F1- CIITA) by transduction the CIITA (Class transactivator) gene....