A5026587236- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Xenotransplantation and immune response
- Lung Cancer Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Magnetic and transport properties of perovskites and related materials
- Advanced Condensed Matter Physics
- Genetic factors in colorectal cancer
- Medical Imaging and Pathology Studies
- Education and Learning Interventions
- Colorectal Cancer Treatments and Studies
- Animal Genetics and Reproduction
- Rare-earth and actinide compounds
- Lymphoma Diagnosis and Treatment
- Advanced Electrical Measurement Techniques
- Radiomics and Machine Learning in Medical Imaging
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Technology and Data Analysis
- Ovarian cancer diagnosis and treatment
- Cancer-related Molecular Pathways
- Gastric Cancer Management and Outcomes
- Extracellular vesicles in disease
- Organ Transplantation Techniques and Outcomes
Korea Research Institute of Standards and Science
2004-2024
Konkuk University
2015-2024
Konkuk University Medical Center
2015-2024
Kumoh National Institute of Technology
2024
Korea University of Science and Technology
2017
Korea University Medical Center
2011
Seoul Veterans Hospital
2009
Ewha Womans University
2008
Chungnam National University
2008
Dong-Eui University
2008
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In Korea, where PTC comprises about 90-95% of the reported thyroid cancers, prevalence BRAF(V600E) mutation in papillary carcinoma (PTC) is above 80%.We analyzed surgical result according to a management guideline based on status nodules.A total 865 nodules were prospectively for their cytology and by pyrosequencing. For patients who had diagnosis atypical cells undetermined significance (ACUS), we recommended surgery when there was positivity or clinically suspicious.Among cases, 504, 141,...
The BRAFV600E mutation in papillary thyroid carcinoma (PTC) is particularly prevalent Korea, and a considerable number of wild-type BRAF PTCs harbor RAS mutations. In addition, subsets other genetic alterations clearly exist, but their prevalence the Korean population has not been well studied. Recent increased insight into noninvasive encapsulated follicular variant PTC prompted endocrine pathologists to reclassify this entity as "noninvasive neoplasm with papillary-like nuclear features"...
Background —Synthetic, not natural, progestagen may negate the favorable effects of estrogen. Nonetheless, observational studies report no differences in risk for clinical cardiovascular events between users unopposed estrogen and combined with synthetic progestin. Methods Results —In a double-blind study, we randomly assigned 20 healthy postmenopausal women to micronized progesterone (MP) 200 mg or medroxyprogesterone acetate (MPA) 10 days conjugated equine (CEE) 0.625 25 remaining 5 off...
Copper nitride nanoparticles supported on a mesoporous superparamagnetic silica microsphere exhibit superior activity toward the Huisgen cycloaddition of azides and alkynes. The catalyst offers significant advantages over homogeneous Cu catalysts.
Tumor angiogenesis is one of the major hallmarks tumor progression. Nobiletin a natural flavonoid isolated from citrus peel that has anti-angiogenic activity. Steroid receptor coactivator (Src) an intracellular tyrosine kinase so focal adhesion (FAK) binds to Src play role in angiogenesis. Signal transducer and activator transcription 3 (STAT3) marker for which interacts with Src. Paxillin (PXN) acts as downstream target both FAK STAT3. The main goal this study was assess inhibition by...
BACKGROUNDThe aim of study was to determine the relative frequency malignant lymphoma according World Health Organization (WHO) classification in Korea.METHODSA total 3,998 cases diagnosed at 31 institutes between 2005 and 2006 were enrolled. Information including age, gender, pathologic diagnosis, site involvement immunophenotypes obtained.RESULTSThe non-Hodgkin (NHL) Hodgkin (HL) 95.4% 4.6%, respectively. B-cell lymphomas accounted for 77.6% all NHL, while T/natural killer (T/NK)-cell...
EGFR genotyping in pulmonary adenocarcinoma patients who develop pleural effusions is mostly performed using cytology or cell block slides with low sensitivity. Liquid biopsy the supernatant of may be more effective because they contain many components released by cancer cells. Extracellular vesicles (EVs) are known to carry oncogenic double-stranded DNA that considered a notable biomarker. Here, we investigate efficiency liquid cell-free (cfDNA) and extracellular vesicle-derived (EV-derived...
The role of telomerase reverse transcriptase (TERT) promoter mutations in differentiated thyroid cancer has been well established. These have a significantly higher prevalence aggressive tumors, including widely invasive oncocytic carcinomas, poorly and anaplastic carcinomas. Interestingly, some studies, TERT were found to be more common tumors with BRAF(V600E) mutation. However, mutational analysis not previously performed for patients Korea, where the mutation papillary carcinoma (PTC) is...
Human embryonic carcinoma (EC; NCCIT) cells have self-renewal ability and pluripotency. Cancer stem cell markers are highly expressed in NCCIT cells, imparting them with the pluripotent nature to differentiate into other cancer types, including breast cancer. As one of main pathways, Wnt/β-catenin is also overexpressed cells. Thus, inhibition these pathways defines a drug target Tannic acid (TA) natural polyphenol present foods, fruits, vegetables that has anti-cancer activity. Through...
Extracellular vesicles (EV) have been proven to contain double-stranded DNA reflecting the mutational status of parental tumor cells in non-small cell lung cancer (NSCLC), which can be translated into clinically useful EV-based liquid biopsy for Epidermal growth factor receptor (EGFR) genotyping using bronchoalveolar lavage fluid (BALF) obtained from site.Patients subjected an initial work-up underwent bronchoscopy and BALF was site. After isolating EVs by ultracentrifugation, EV-derived (EV...
The transport and magnetic properties of single crystals ${\mathrm{La}}_{1\ensuremath{-}x}{\mathrm{Ca}}_{x}{\mathrm{MnO}}_{3}$ $(x=0.2,$ 0.3) have been investigated. magnetization results the ferromagnetic insulator, ${\mathrm{La}}_{0.8}{\mathrm{Ca}}_{0.2}{\mathrm{MnO}}_{3},$ are quite different from those ${\mathrm{La}}_{0.7}{\mathrm{Ca}}_{0.3}{\mathrm{MnO}}_{3}$ that falls into a metal. We found paramagnetic to transitions observed in...
Genetic alterations of TERT and CTNNB1 have been documented in hepatocellular carcinoma. promoter mutations are the earliest genetic events multistep process hepatocarcinogenesis related to cirrhosis. However, analyses carcinoma tumor samples not performed Korean population, where hepatitis B virus-related is prevalent. In order identify role pathogenesis recurrent carcinoma, we sequence 140 nodules (including 107 carcinomas), 8 pairs matched primary relapsed carcinomas. were only observed...
Combination therapy, which reduces the dosage intensity of individual drugs while increasing their efficacy, is not a novel approach for treatment cancer. Methylsulfonylmethane (MSM) an organic sulfur compound shown to act against tumor cells. Tamoxifen commercially available therapeutic agent breast malignancies.In current study, we analyzed combinatorial effect MSM and tamoxifen on suppression ER-positive cancer xenograft growth metastasis. Additionally, also validated molecular targets by...
Matrix metalloproteinases (MMPs) are matrix-degrading enzymes that play a pivotal role in aggressive behaviours, such as rapid tumour growth, invasion, and metastasis, of several types solid tumours. In particular, stromal MMP-2 plays important roles the progression malignant tumours, but most clinical studies have focused on tumoural -9 expression, not expression. One hundred seventy-seven cases diagnosed invasive ductal carcinoma breast between 2000 2005 were included this study....
Purpose: Triple-negative breast cancer (TNBC) represents a major clinical challenge due to its aggressive and metastatic behavior the lack of available targeted therapies.Therefore, therapeutic strategies are needed improve TNBC patient management.Recently, atezolizumab nab-paclitaxel chemotherapy has been approved by Food Drug Administration for first-line treatment patients with locally advanced TNBC.The programmed death-ligand 1 (PD-L1) immunohistochemical SP142 assay was also as...
Abstract Background Despite surgical resection, early lung adenocarcinoma has a recurrence rate of 20–50%. No clear predictive markers for are available. Targeted next-generation sequencing (NGS) is rarely used to identify recurrence-related genes. We aimed genetic alterations that can predict recurrence, by comparing the molecular profiles patient groups with and without recurrence. Methods Tissues from 230 patients resected stage I–II (median follow-up: 49 months) were analyzed via...
Extracellular vesicles (EVs) are membrane-bound and nanometer-sized particles released from most types of cells, containing double-stranded DNA reflecting mutational status the parental tumor cells. Furthermore, epidermal growth factor receptor (EGFR) genotyping using EV-derived (EV DNA) in bronchoalveolar lavage fluid (BALF) showed almost 100% sensitivity patients with advanced non-small cell lung cancer (NSCLC).We assessed technical performance derived BALF-EV (BALF EV targeted...
Direct sequencing is the standard method for detection of epidermal growth factor receptor (EGFR) mutations in lung cancer, however, its relatively low sensitivity limits clinical use. Pyrosequencing a bioluminometric, real-time non-electrophoretic DNA technique with number advantages compared direct sequencing, including higher sensitivity, speed, automation and cost-effectiveness. Clinical specimens from 202 cancer patients were analyzed EGFR exons 18, 19, 20 21 using pyrosequencing...
ERG, a member of the ETS family transcription factors, is highly specific endothelial marker. We investigated whether use ERG immunostaining can help pathologists detect lymphovascular invasion (LVI) and decrease interobserver variability in LVI diagnosis.Fifteen cases surgically resected colorectal cancers with hepatic metastasis were selected most representative sections for detection immunostained CD31, D2-40. Eight independently evaluated status on hematoxylin eosin (H&E) corresponding...
Follicular variant of papillary thyroid carcinoma (FVPTC), particularly the encapsulated subtype, often causes a diagnostic dilemma. We reconfirmed molecular profiles in large number FVPTCs and investigated efficacy preoperative mutational analysis indeterminate nodules. BRAF V600E/K601E RAS was performed on 187 FVPTCs. Of these, 132 (70.6%) had point mutation one V600E (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
A subpopulation of breast cancer cells with cluster differentiation (CD)44-positive and CD24-negative expression has been reported to have stem cell properties a higher tumorigenic capacity than other cells. However, the clinicopathological characteristics this are not fully understood. In study, we aimed identify correlations between CD44 CD24 parameters overall survival. We studied specimens from 262 patients invasive cancer. Immunohistochemical staining for was performed using tissue...