A5074946587- Genetic and phenotypic traits in livestock
- Animal Nutrition and Physiology
- Genetic Mapping and Diversity in Plants and Animals
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Meat and Animal Product Quality
- interferon and immune responses
- Animal Genetics and Reproduction
- T-cell and B-cell Immunology
- Adipose Tissue and Metabolism
- Cancer-related molecular mechanisms research
- Coccidia and coccidiosis research
- Antimicrobial Peptides and Activities
- Molecular Biology Techniques and Applications
- Veterinary medicine and infectious diseases
- Muscle metabolism and nutrition
- RNA and protein synthesis mechanisms
- Probiotics and Fermented Foods
- RNA Research and Splicing
- Gut microbiota and health
- Influenza Virus Research Studies
- Muscle Physiology and Disorders
- Metabolism, Diabetes, and Cancer
- Caveolin-1 and cellular processes
- Livestock and Poultry Management
Hangzhou Medical College
2025
Zhejiang Provincial People's Hospital
2025
Jeonbuk National University
2015-2024
National Institute of Veterinary Research
2021
Hoseo University
2021
Chung-Ang University
2021
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2009-2020
National Institutes of Health
1998-2020
Ankara University
2020
Chonbuk National University Hospital
2020
The history of African indigenous cattle and their adaptation to environmental human selection pressure is at the root remarkable diversity. Characterization this diversity an essential step towards understanding genomic basis productivity survival under farming systems. We analyze patterns genetic variation by sequencing 48 genomes from five populations comparing them 53 commercial taurine breeds. find highest among zebu sanga cattle. Our search for regions reveals signatures adaptive...
Probiotics in livestock feed supplements are considered a replacement for antibiotics that enhance gastrointestinal immunity. Although bacterial cell wall components have been proposed to be associated with probiotic function, little evidence demonstrates they responsible functions livestock. The present study demonstrated lipoteichoic acid of Lactobacillus plantarum (Lp.LTA) confers anti-inflammatory responses porcine intestinal epithelial line, IPEC-J2. A synthetic analog viral...
Tumor angiogenesis is one of the major hallmarks tumor progression. Nobiletin a natural flavonoid isolated from citrus peel that has anti-angiogenic activity. Steroid receptor coactivator (Src) an intracellular tyrosine kinase so focal adhesion (FAK) binds to Src play role in angiogenesis. Signal transducer and activator transcription 3 (STAT3) marker for which interacts with Src. Paxillin (PXN) acts as downstream target both FAK STAT3. The main goal this study was assess inhibition by...
Caveolin 1 (Cav-1) is a plasma membrane-associated protein with the capacity to modulate signaling activities in context-dependent fashion. Interactions between Cav-1 and low-density lipoprotein receptor-related 6 (LRP6) were reported be important for regulation of Wnt-β-catenin (β-cat) signaling. also interacts insulin IGF-I receptors (IGF-IR/IR) can stimulate IR kinase activities. We found positive correlation LRP6 expression both human primary prostate cancer metastasis tissues PC-3...
Intestinal barrier is the first line of defense inside body and comprises intercellular tight junction (TJ) proteins that regulate paracellular permeability. Deoxynivalenol (DON), a fungal metabolite often found in contaminated food domestic animals, known to impair intestinal function may be involved inflammation. Unlike humans mice, importance Toll-like receptor (TLR) 2 expressed porcine epithelial cells largely unclear. Therefore, aim present study was investigate whether TLR2 stimulation...
ABSTRACT Aim To explore the relationship between an innovative anoikis‐related gene signature and inflammatory infiltrates in patients with osteoarthritis. Methods Gene expression profiles (GSM1248759 GSE200843) were curated from Expression Omnibus database, followed by construction of a protein–protein interaction network. Functional genomic enrichment analyses conducted using Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) databases. The CIBERSORT method was employed to investigate...
Negative selection and regulatory T (T reg) cell development are two thymus-dependent processes necessary for the enforcement of self-tolerance, both require high-affinity interactions between receptor (TCR) self-ligands. However, it remains unclear if they similarly impacted by alterations in TCR signaling potential. We generated a knock-in allele (6F) ζ chain gene encoding mutant protein lacking capability whose expression is controlled endogenous sequences. Although negative was defective...
Genetic parameters of Berkshire pigs for reproduction, carcass and meat quality traits were estimated using the records from a breeding farm in Korea. For reproduction traits, 2,457 total number piglets born (TNB) alive (NBA) 781 sows 53 sires used. two which are weight (CW) backfat thickness (BF) 10 pH value after 45 minutes (pH45m), 24 hours (pH24h), lightness color (LMC), redness (RMC), yellowness (YMC), moisture holding capacity (MHC), drip loss (DL), cooking (CL), fat content (FC),...
Since being domesticated about 10,000–12,000 years ago, domestic pigs (Sus scrofa domesticus) have been selected for traits of economic importance, in particular large body size. However, Yucatan miniature small size to withstand high temperature environment and laboratory use. This renders the pig a valuable model understanding evolution We investigate genetic signature selection pig. Phylogenetic distance was compared other swine breeds (Yorkshire, Landrace, Duroc wild boar). By estimating...
Abstract Toll-like receptor 3 (TLR3), an endosomal crucial for immune responses upon viral invasion. The TLR3 ectodomain (ECD) is responsible double-stranded RNA (dsRNA) recognition and mutational analysis suggested that ECD C-terminal dimerization essential dsRNA binding. Moreover, the L412F polymorphism of associated with human diseases. Although mouse structure TLR3-dsRNA complex provides valuable insights, structural dynamic behavior in humans not completely understood. Hence, this...
In this study, we examined the therapeutic effects of an immune-stimulating peptide, WKYMVm, in ulcerative colitis. The administration WKYMVm to dextran sodium sulfate (DSS)-treated mice reversed decreases body weight, bleeding score and stool addition reversing DSS-induced mucosa destruction shortened colon. WKYMVm-induced effect against colitis was strongly inhibited by a formyl peptide receptor (FPR) 2 antagonist, WRWWW.W, indicating crucial role FPR2 effect. Mechanistically, effectively...
Abstract Exosomes are membrane vesicles containing proteins, lipids, DNA, mRNA, and micro RNA (miRNA). Exosomal miRNA from donor cells can regulate the gene expression of recipient cells. Here, Ri chickens were divided into resistant ( Mx /A; BF2 / B21 ) susceptible /G; B13 trait by genotyping genes. Then, infected with H5N1, a highly pathogenic avian influenza virus (HPAIV). purified blood serum for small sequencing. Sequencing data analysed using FastQCv0.11.7, Cutadapt 1.16, miRBase v21,...