A5041121559- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Cancer-related molecular mechanisms research
- Meat and Animal Product Quality
- Animal Nutrition and Physiology
- Agriculture, Soil, Plant Science
- Food Quality and Safety Studies
- Silkworms and Sericulture Research
- Nutrition, Health and Food Behavior
- Livestock and Poultry Management
- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- RNA Research and Splicing
- interferon and immune responses
- Animal Genetics and Reproduction
- Genetics and Plant Breeding
- Antimicrobial Peptides and Activities
- Probiotics and Fermented Foods
- Immune Response and Inflammation
- Gut microbiota and health
- Identification and Quantification in Food
- Genetic diversity and population structure
- Biochemical Analysis and Sensing Techniques
- RNA regulation and disease
- RNA modifications and cancer
Hankyong National University
2005-2024
Jeonbuk National University
2015-2023
Iowa State University
2015
National Institute of Animal Science
2009
A main goal of cattle genomics is to identify DNA differences that account for variations in economically important traits. In this study, we performed whole-genome analyses three breeds Korea—Hanwoo, Jeju Heugu, and Korean Holstein—using the Illumina HiSeq 2000 sequencing platform. We achieved 25.5-, 29.6-, 29.5-fold coverage Hanwoo, Holstein genomes, respectively, identified a total 10.4 million single nucleotide polymorphisms (SNPs), which 54.12% were found be novel. also detected...
Recently, substantial interest has been generated in using electrospun biomimetic nanofibers of hybrids, particularly organic/inorganic, to engineer different tissues. The present work, for the first time, introduced a unique natural and synthetic hybrid micronanofiber wound dressing, composed virgin olive oil/copper oxide nanocrystals polyurethane (PU), developed via facile electrospinning. as-spun organic/inorganic micronanofibers were characterized by scanning electron microscopy (SEM),...
Since being domesticated about 10,000–12,000 years ago, domestic pigs (Sus scrofa domesticus) have been selected for traits of economic importance, in particular large body size. However, Yucatan miniature small size to withstand high temperature environment and laboratory use. This renders the pig a valuable model understanding evolution We investigate genetic signature selection pig. Phylogenetic distance was compared other swine breeds (Yorkshire, Landrace, Duroc wild boar). By estimating...
Whole-genome sequence (WGS) data are increasingly being applied into genomic predictions, offering a higher predictive ability by including causal mutations or single-nucleotide polymorphisms (SNPs) putatively in strong linkage disequilibrium with affecting the trait. This study aimed to improve performance of customized Hanwoo 50 k SNP panel for four carcass traits commercial population adding highly variants from data. A total 16,892 cattle phenotypes (i.e., backfat thickness, weight,...
Necrotic enteritis (NE) is a re-emerging disease as result of increased restriction on the use antibiotics in poultry. However, molecular mechanisms underlying pathogenesis NE are unclear. Small RNA transcriptome analysis was performed using spleen and intestinal intraepithelial lymphocytes (IEL) from 2 inbred chicken lines selected for resistance or susceptibility to Marek's (MD) an experimentally induced model avian investigate whether microRNA (miRNA) control expression genes associated...
The purpose of this study was to assess the genetic variation and establish relationship amongst breeds strains using 15 chicken specific microsatellite markers.A total 285 unrelated DNA samples from four Korean native (Black strain chicken; KL, Red Brown KR, Ogol KS Yellow KY) three introduced (F White Leghorn; LF, K LK, Rhode Island Red; RC Cornish; CN) were genotyped estimate within between breed diversity indices.All loci analyzed in markers showed a polymorphic pattern number alleles...
Pork from Jeju black pig (population J) and Berkshire B) has a unique market share in Korea because of their high meat quality. Due to the demand this pork, traceability pork its origin is becoming an important part consumer demand. To examine feasibility such system, we aim provide basic genetic information two populations assess possibility genetically distinguishing between breeds. Muscle samples were collected slaughter houses Island Namwon, Chonbuk province, Korea, for J B,...
This study was conducted to establish an individual identification system comprising of 19 microsatellite markers located on different bovine autosomes.The were typed 257 animals from five cattle breeds.In total, 112 alleles detected the genotyping markers.The average heterozygosities ranged 0.292 0.824 and polymorphic information content (PIC) 0.274 0.817 in Hanwoo.We found that there differences allele frequencies Hanwoo when compared with other breeds.The calculated cumulative power...
The effects of diacylglycerol O-acyltransferase (DGAT1) candidate gene polymorphism on the economic traits Hanwoo were studied.Through sequencing analysis, two sites at K232A and T11993C established analyzed by PCR-RFLP.The PCR-RFLP analysis for showed that frequencies alleles K A 0.75 0.25, respectively, genotypes K/K, K/A A/A estimated as 0.509, 0.491 0, respectively.In T11993C, we found allele 0.773 0.227 T A, 0.546, 0.454 0 T/T, T/C C/C genotype frequencies, respectively.No significant...
The genomic best linear unbiased prediction (GBLUP) method has been widely used in routine evaluation as it assumes a common variance for all single nucleotide polymorphism (SNP). However, this is unlikely the case of traits influenced by major SNP. Hence, present study aimed to improve accuracy GBLUP using weighted (WGBLUP), which gives more weight important markers various carcass Hanwoo cattle, such backfat thickness (BFT), (CWT), eye muscle area (EMA), and marbling score (MS). Linear...
This study aimed to evaluate the accuracy of genomic prediction using single-trait and multi-trait single-step best linear unbiased (ssGBLUP) based on 50 K SNP chip dataset imputed high-density (HD) genotypes for various carcass traits in commercial Hanwoo population such as backfat thickness (BFT), weight (CWT), rib eye area (REA), marbling score (MS). Analyses involved phenotypes from 18,269 animals born between April 2006 June 2017 different herds South Korea well information 16,892...
Beef consumers valued meat quality traits such as texture, tenderness, juiciness, flavor, and color that determining consumers' purchasing decision. Most research on has focused marbling, a key characteristic related to eating quality. However, other important have not much studied in cattle. Among these traits, tenderness texture of cattle are among the most factors affecting evaluation consumers. Collagen is main component connective tissues.It greatly affects tenderness. The objective...
Japanese quail (Coturnix coturnix japonica) reach sexual maturity earlier, breed rapidly and successfully, cost less require space than other birds raised commercially. Given the value of this species for food production experimental use, more studies are necessary to determine chromosomal regions genes associated with gender breed-differentiation. This study employed Trinity edgeR transcriptome analysis next-generation RNA-seq data, which included 4 tissues obtained from 3 different...
Long noncoding RNAs (lncRNAs) regulate the expression of mRNA and can affect various biological processes phenotypes. Currently, studies lncRNAs in cattle are under way, but their exact function for several tissues has not yet been established. Hanwoo (Bos taurus coreanae) have inhabited Korean peninsula about 6000 years one representative domesticated animals Korea. As a result intensive breeding, meat is high marbling content preferred by Koreans other East Asian people. In this study, was...
Abstract Malignant melanoma is highly resistant to conventional treatments and one of the most aggressive types skin cancers. Conventional cancer are limited due drug resistance, tumor selectivity, solubility. Therefore, new with fewer side effects excellent should be developed. In previous studies, we have analyzed antimicrobial peptides (AMPs), which showed antibacterial anti-inflammatory in insects, some AMPs also exhibited anticancer efficacy. Anticancer (ACPs) known high this study,...
Salmonella enterica serovar Typhimurium isolate HJL777 is a virulent bacterial strain in pigs. The high rate of salmonella infection are at risk non-typhoidal gastroenteritis development. Salmonellosis most common young We investigated changes gut microbiota and biological function piglets infected with via analysis rectal fecal metagenome intestinal transcriptome using 16S rRNA RNA sequencing. identified decrease Bacteroides increase harmful bacteria such as Spirochaetes Proteobacteria by...
The Korean Native Chicken (KNC) is an important endemic biological resource in Korea. While numerous studies have been conducted exploring this breed, none used next-generation sequencing to identify its specific genomic features. We sequenced five strains of KNC and identified 10.9 million SNVs 1.3 InDels. Through the analysis, we found that highly variable region common all 5 had genes like PCHD15, CISD1, PIK3C2A, NUCB2 might be related phenotypic traits chicken such as auditory sense,...
Antimicrobial peptides (AMPs) are an important component of innate defense mechanisms with broad-spectrum activities against various pathogenic microorganisms, including Gram-positive and Gram-negative bacteria, fungi, viruses. Antibiotic resistance has become a pervasive global health burden, resulting in the immediate need to develop new class antibiotic substances. We screened 16-mer random peptide library using yeast two-hybrid system Beclin 1 as bait found that two (named P4 P30)...
c-MYC (v-myelocytomatosis viral oncogene homologue) is a transcription factor that plays important role in many biological process including cell growth and differentiation, such as myogenesis adipogenesis. In this study, we aimed to detect MYC gene polymorphisms, their genotype frequencies determine associations between these polymorphisms meat quality traits Berkshire pigs. We identified single nucleotide polymorphism (SNP) intron 2 of by Sanger sequencing, i.e., g.3350G>C (rs321898326),...