Sara de las Heras‐Saldana

ORCID: 0000-0002-8665-6160
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Research Areas
  • Genetic and phenotypic traits in livestock
  • Cancer-related molecular mechanisms research
  • Genetic Mapping and Diversity in Plants and Animals
  • Animal Genetics and Reproduction
  • Animal Nutrition and Physiology
  • Ruminant Nutrition and Digestive Physiology
  • Insect and Arachnid Ecology and Behavior
  • Effects of Environmental Stressors on Livestock
  • Reproductive Physiology in Livestock
  • Muscle Physiology and Disorders
  • Sperm and Testicular Function
  • Molecular Biology Techniques and Applications
  • Microbial Metabolic Engineering and Bioproduction
  • Animal Behavior and Welfare Studies
  • Antioxidant Activity and Oxidative Stress
  • Tissue Engineering and Regenerative Medicine
  • Moringa oleifera research and applications
  • Aquaculture Nutrition and Growth
  • Peroxisome Proliferator-Activated Receptors
  • Cholesterol and Lipid Metabolism
  • Metabolomics and Mass Spectrometry Studies
  • Food Quality and Safety Studies
  • Insect and Pesticide Research
  • Meat and Animal Product Quality
  • Livestock Farming and Management

University of New England
2016-2025

National Institute of Animal Science
2023

Michigan State University
2019

Abstract Background In this study, we assessed the accuracy of genomic prediction for carcass weight (CWT), marbling score (MS), eye muscle area (EMA) and back fat thickness (BFT) in Hanwoo cattle when using best linear unbiased (GBLUP), weighted GBLUP (wGBLUP), a BayesR model. For these models, investigated potential gain from pre-selected single nucleotide polymorphisms (SNPs) genome-wide association study (GWAS) on imputed sequence data gene expression information. We used 13,717 animals...

10.1186/s12711-020-00574-2 article EN cc-by Genetics Selection Evolution 2020-09-29

Protein is an essential component of poultry diets and directly influences growth performance, profitability, the environment. While relationship between animal performance nutrient intake modulated by gene expression, transcriptomic mechanisms underlying broiler adaptation to varying dietary protein levels remain underexplored. This research investigated liver response chickens fed a reduced crude (RCP) diet, aiming identify differentially expressed genes (DEGs) metabolic pathways that may...

10.1016/j.psj.2025.104920 article EN cc-by Poultry Science 2025-02-01

Ram semen traits play a significant role in conception outcomes, which turn may influence reproductive efficiency and the overall productivity profitability of sheep enterprises. Since hundreds ewes be inseminated from single ejaculate, it is important to evaluate quality prior use breeding programs. Given that have been found heritable, genetic variation likely contributes variability observed these traits. Identifying such variants could provide novel insights into molecular mechanisms...

10.3390/ani13142286 article EN cc-by Animals 2023-07-12

Genome-wide association studies (GWAS) are extensively used to identify single nucleotide polymorphisms (SNP) underlying the genetic variation of complex traits. However, much uncertainly often still exists about causal variants and genes at quantitative trait loci (QTL). The aim this study was QTL associated with residual feed intake (RFI) in these regions whose expression is also trait. Angus cattle (2190 steers) RFI records were genotyped imputed high density arrays (770 K) for a GWAS...

10.1186/s12864-019-6270-4 article EN cc-by BMC Genomics 2019-12-01

Maintaining genetic diversity and variation in livestock populations is critical for natural artificial selection promoting improvement while avoiding problems due to inbreeding. In Laos, there are concerns that has been a decline rise inbreeding among native goats their village-based smallholder system. this study, we investigated the of Lao Phin, Songkhone Sepon districts Central Laos first time using Illumina's Goat SNP50 BeadChip. We also explored relationships between with 163 global...

10.1111/jbg.12862 article EN cc-by-nc Journal of Animal Breeding and Genetics 2024-03-22

Korean Hanwoo cattle are known for their high meat quality, especially intramuscular fat compared to most other breeds. Different muscles have very different quality traits and a study of the myogenic process in satellite cells can help us better understand genes pathways that regulate this how differentiate.Cell cultures Longissimus dorsi muscle differentiated from myoblast into multinucleated myotubes faster than semimembranosus. Time-series RNA-seq identified total 13 differentially...

10.1186/s12864-019-5530-7 article EN cc-by BMC Genomics 2019-02-26

It is well known that male and female broilers differ in their growth performance many physiological factors contribute to this difference. The aim of experiment investigate if there are differences between males cecal microbiota nutrient transporter gene expression these play a role the broilers. possible effect protein level its interaction with sex on transporters were also investigated. Samples collected from birds fed either standard crude (SCP) or reduced diets (RCP) at age d 35. was...

10.1016/j.psj.2023.103268 article EN cc-by Poultry Science 2023-11-07

Hanwoo breed is preferred in South Korea because of the high standards marbling and palatability its meat. Numerous studies have been conducted are ongoing to increase meat production quality this beef population. The aim study was estimate compare genetic parameters for carcass traits using BLUPF90 software. Four models were constructed, single trait pedigree model (STPM), single-trait genomic (STGM), multi-trait (MTPM), (MTGM), pedigree, phenotype, information 7991 cattle. evaluated: Back...

10.3390/ani9121061 article EN cc-by Animals 2019-12-02

The genomic best linear unbiased prediction (GBLUP) method has been widely used in routine evaluation as it assumes a common variance for all single nucleotide polymorphism (SNP). However, this is unlikely the case of traits influenced by major SNP. Hence, present study aimed to improve accuracy GBLUP using weighted (WGBLUP), which gives more weight important markers various carcass Hanwoo cattle, such backfat thickness (BFT), (CWT), eye muscle area (EMA), and marbling score (MS). Linear...

10.3390/genes10121019 article EN Genes 2019-12-06

The Korean Hanwoo breed possesses a high capacity to accumulate intramuscular fat, which is measured as marbling score in the beef industry. Unfortunately, development of not completely understood and identification differentially expressed genes at an early age required better understand this trait. In study, we took muscle samples from 12 steers 18 30 months. From contrast between score, identified total 1883 (FDR < 0.05 logarithm fold change ≥ 1.5) with 782 up-regulated 1101...

10.3390/genes11111381 article EN Genes 2020-11-21

Necrotic enteritis (NE) is an important enteric disease in poultry and has become a major concern production the post-antibiotic era. The infection with NE can damage intestinal mucosa of birds leading to impaired health and, thus, productivity. To gain better understanding how impacts gut function infected broilers, global mRNA sequencing (RNA-seq) was performed jejunum tissue challenged non-challenged broilers identify pathways genes affected by this disease. Briefly, induce NE, challenge...

10.1016/j.aninu.2020.08.003 article EN cc-by-nc-nd Animal nutrition 2020-12-17

Reduced reproductive efficiency results in economic losses to the Australian sheep industry. Reproductive success, particularly after artificial insemination, is dependent on a number of contributing factors both ewe and ram sides. Despite considerable emphasis placed characterising side contributions, little has been contributions conception success. Over 14,000 transcripts are spermatozoa other species, which transferred ova fertilisation. These conceivably influence early embryonic...

10.3390/genes12020203 article EN Genes 2021-01-30

Semen characteristics including volume, gross motility, spermatozoal concentration, and percent post-thaw motility are routinely assessed to determine the quality quantity of an ejaculate prior use in artificial breeding programs. Currently, programs sheep place relatively little emphasis on ram-side factors, such as fertilising potential ejaculate, which may contribute variability conception outcomes. Estimating genetic parameters for traits could provide insights into whether selective can...

10.3390/ani12212946 article EN cc-by Animals 2022-10-26

Abstract The aim of this study was to find significant genomic regions associated with carcass traits in Hanwoo cattle and compare the benefit using additional information from non‐genotyped animals. Imputed whole‐genome sequence data were used along phenotypic on 13 715 genotyped animals as well phenotypes 440 284 that offspring 454 sires. For weight, 15 083 SNPs 33 QTL 313 candidate genes identified. We found 410 17 containing 122 for back fat thickness. In total, 656 19 QTLs 137 eye...

10.1111/age.13251 article EN Animal Genetics 2022-08-22

A 1932 editorial in Poultry Science stated that sampling theory, or experimental power, could be useful for "the investigator to know how many … birds put into each pen." Nevertheless, the past 90 yr, appropriate power estimates have rarely been applied research with poultry. To estimate overall variation and use of resources animals pens, a nested analysis should conducted. Bird-to-bird separate pen-to-pen variances were separated 2 datasets, one from Australia North America. The...

10.1016/j.psj.2023.102698 article EN cc-by-nc-nd Poultry Science 2023-04-12

Context Genomic prediction is the use of genomic data in estimation breeding values (GEBV) animal breeding. In beef cattle programs, increases rates genetic gain by increasing accuracy selection at earlier ages. Aims The objectives study were to examine effect single-nucleotide polymorphism (SNP) density and evaluate using SNPs preselected from imputed whole-genome sequence for prediction. Methods phenotypic 2110 Hanwoo steers used predict GEBV marbling score (MS), meat texture (MT), colour...

10.1071/an20659 article EN Animal Production Science 2021-11-05

Poultry production is among the most challenging industries for pathogen control. High animal density and abundance of faecal material demand strict biosecurity measures continual vigilance in monitoring health parameters. Despite this vigilance, dealing with disease outbreaks a part farmers' routines. Phytogenic feed additives comprised herbs, spices, essential oils, oleoresins have potent antimicrobial anti-inflammatory actions. Related studies are gaining substantial interest human...

10.3390/antibiotics11101428 article EN cc-by Antibiotics 2022-10-18

Hanwoo cattle are known for their high meat quality, particularly marbling (intramuscular fat) ability compared with most other breeds. Meat flavor and tenderness largely determined by intramuscular fat composition, muscle fiber characteristics connective tissue structures. All of these factors differ between types, but it is not well how this differentiation occurs what genes pathways regulate the process. To better understand myogenic processes involved in we performed a time-series...

10.2527/jas2016.94supplement477x article EN Journal of Animal Science 2016-09-01

Most carcass and meat quality traits are moderate to highly heritable, indicating that they can be improved through selection. Genetic evaluation for these types of is performed using performance data obtained from commercial progeny testing evaluation. The farms available in large volume, however, some drawbacks have been observed. drawback the mainly due sorting animals based on live weight prior slaughter, this could lead bias genetic later measured such as traits. current study has two...

10.5187/jast.2023.e36 article EN cc-by-nc Journal of Animal Science and Technology 2023-04-24

Abstract Hanwoo, Korean native cattle, have been known for high intramuscular adipose tissue compare to other beef cattle. Bovine satellite cells (BSC) of longissimus dorsi (LD) and semimembranosus (SM) tissues differentiated from myoblast into multinucleated myotubes has different characteristics under cell culture system. Differentially expressed genes (DEG) the two muscle were compared based on 24, 48, 96, 168 hours. Difference in index between LD SM BSC at each time point tested with an...

10.1093/jas/skz258.618 article EN Journal of Animal Science 2019-12-01
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