Clyde Francks
A5047361673- Hemispheric Asymmetry in Neuroscience
- Genetics and Neurodevelopmental Disorders
- Genetic Associations and Epidemiology
- Functional Brain Connectivity Studies
- Reading and Literacy Development
- Congenital heart defects research
- Autism Spectrum Disorder Research
- Morphological variations and asymmetry
- Genomic variations and chromosomal abnormalities
- Genomics and Rare Diseases
- Attention Deficit Hyperactivity Disorder
- Dermatoglyphics and Human Traits
- Bioinformatics and Genomic Networks
- Advanced Neuroimaging Techniques and Applications
- Epigenetics and DNA Methylation
- Cognitive and developmental aspects of mathematical skills
- Cognitive Abilities and Testing
- Language Development and Disorders
- Health, Environment, Cognitive Aging
- Medical and Biological Sciences
- Action Observation and Synchronization
- Spatial Neglect and Hemispheric Dysfunction
- RNA modifications and cancer
- Spaceflight effects on biology
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Max Planck Institute for Psycholinguistics
2016-2025
Radboud University Nijmegen
2016-2025
Radboud University Medical Center
2014-2025
University Medical Center
2022-2024
Allen Institute for Brain Science
2023
Max Planck Society
2012-2021
University of Southern California
2019
Amsterdam Neuroscience
2019
The Ohio State University
2019
GlaxoSmithKline (Netherlands)
2014
Autism is characterized by impairments in reciprocal social interaction and communication, restricted stereotyped patterns of interests activities. Developmental difficulties are apparent before 3 years age there evidence for strong genetic influences most likely involving more than one susceptibility gene. A two-stage genome search loci autism was performed on 87 affected sib pairs plus 12 non-sib relative-pairs, from a total 99 families identified an international consortium. Regions six...
We report a genome-wide assessment of single nucleotide polymorphisms (SNPs) and copy number variants (CNVs) in schizophrenia. investigated SNPs using 871 patients 863 controls, following up the top hits four independent cohorts comprising 1,460 12,995 all European origin. found no significant associations, nor could we provide support for any previously reported candidate gene or associations. went on to examine CNVs subset 1,013 cases 1,084 controls ancestry, further set 60 64 African...
Abstract Altered structural brain asymmetry in autism spectrum disorder (ASD) has been reported. However, findings have inconsistent, likely due to limited sample sizes. Here we investigated 1,774 individuals with ASD and 1,809 controls, from 54 independent data sets of the ENIGMA consortium. was significantly associated alterations cortical thickness mostly medial frontal, orbitofrontal, cingulate inferior temporal areas, also orbitofrontal surface area. These differences generally involved...
Abstract Hand preference is a conspicuous variation in human behaviour, with worldwide proportion of around 90% people preferring to use the right hand for many tasks, and 10% left hand. We used large cohort UK biobank (~500,000 participants) study possible relations between early life factors adult preference. The probability being left-handed was affected by year location birth, likely due cultural effects. In addition, birthweight, part multiple season breastfeeding, sex, each effect...
Left-right hemispheric asymmetry is an important aspect of healthy brain organization for many functions including language, and it can be altered in cognitive psychiatric disorders. No mechanism has yet been identified establishing the human brain's left-right axis. We performed multivariate genome-wide association scanning cortical regional surface area thickness asymmetries, subcortical volume using data from 32,256 participants UK Biobank. There were 21 significant loci associated with...
The use of spoken and written language is a fundamental human capacity. Individual differences in reading- language-related skills are influenced by genetic variation, with twin-based heritability estimates 30 to 80% depending on the trait. architecture complex, heterogeneous, multifactorial, but investigations contributions single-nucleotide polymorphisms (SNPs) were thus far underpowered. We present multicohort genome-wide association study (GWAS) five traits assessed individually using...
Dyslexia is one of the most prevalent childhood cognitive disorders, affecting ∼5% school-age children. We have recently identified a risk haplotype associated with dyslexia on chromosome 6p22.2 which spans TTRAP gene and portions THEM2 KIAA0319 . Here we show that in presence haplotype, expression reduced but other two genes remains unaffected. Using situ hybridization, detect very distinct pattern developing cerebral neocortex mouse human fetuses. Moreover, interference rat Kiaa0319 utero...