A5101677946- Genetic and phenotypic traits in livestock
- Cancer-related molecular mechanisms research
- Gut microbiota and health
- Probiotics and Fermented Foods
- Bioinformatics and Genomic Networks
- Genetic Mapping and Diversity in Plants and Animals
- RNA and protein synthesis mechanisms
- Computational Drug Discovery Methods
- Heat shock proteins research
- Infant Nutrition and Health
- Animal Nutrition and Physiology
- Antimicrobial Peptides and Activities
- Alkaline Phosphatase Research Studies
- FOXO transcription factor regulation
- Spaceflight effects on biology
- 14-3-3 protein interactions
- Biomedical Text Mining and Ontologies
- interferon and immune responses
- Gene expression and cancer classification
- Immune Response and Inflammation
- Machine Learning in Bioinformatics
- Plant and Fungal Interactions Research
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- Oral microbiology and periodontitis research
Chonnam National University
2025
Jeonbuk National University
2019-2023
Korea Advanced Institute of Science and Technology
2008
The interaction between the Niemann-Pick C1 (NPC1) protein and glycoprotein (GP) of filoviruses is essential for viral entry into host cells. Single nucleotide polymorphisms (SNPs) in NPC1, which lead to amino acid substitutions, can significantly alter efficiency. However, quantitative impact these SNPs remains unclear. To address this, we investigate vitro cell-to-cell infection using a plaque assay with vesicular stomatitis virus (VSV) expressing Ebola Marburg GP. We employ an agent-based...
Abstract Toll-like receptor 3 (TLR3), an endosomal crucial for immune responses upon viral invasion. The TLR3 ectodomain (ECD) is responsible double-stranded RNA (dsRNA) recognition and mutational analysis suggested that ECD C-terminal dimerization essential dsRNA binding. Moreover, the L412F polymorphism of associated with human diseases. Although mouse structure TLR3-dsRNA complex provides valuable insights, structural dynamic behavior in humans not completely understood. Hence, this...
Probiotics can modulate the composition of gut microbiota and benefit host animal health in multiple ways. Lactic acid bacteria (LAB), mainly Lactobacillus Bifidobacterium species, are well-known microbes with probiotic potential. In present study, 88 microbial strains were isolated from canine feces annotated. Among these, four CACC517, 537, 558, 566 tested for characteristics, their beneficial effects on hosts evaluated both vitro vivo ; these exhibited antibiosis, antibiotic activity,...
AIM2 and IFI16 are the most studied members of AIM2-like receptors (ALRs) in humans share a common N-Terminal PYD domain C-terminal HIN domain. The binds to dsDNA response invasion bacterial viral DNA, directs apoptosis-associated speck-like protein via protein–protein interactions. Hence, activation is crucial for protection against pathogenic assaults, any genetic variation these inflammasomes can dysregulate human immune system. In this study, different computational tools were used...
Although conserving native pig breeds is important in Korea, research on the genomic aspects to identify breed-specific variations uncommon. Single nucleotide polymorphisms (SNPs) can be a powerful source for identifying variants. We used whole genome sequencing data, including Jeju Native Pig (JNP), Korean (KNP), Wild Boar (KWB), and other western commercial determine SNPs. Furthermore, goal was not only specificity of but also SNPs that carry information (breed-informative SNPs) related...
Lactobacillus acidophilus is a gram-positive, microaerophilic, and acidophilic bacterial species. L. strains in the gastrointestinal tracts of humans other animals have been profiled, but found canine gut not studied yet. Our study helps understanding genetic features C5 strain gut, determining its adaptive evolved to survive environment, elucidating probiotic functions. To examine genome, we isolated from Korean dog sequenced it using PacBio SMRT sequencing technology. A comparative genomic...
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Objective: Cattle were some of the first animals domesticated by humans for production milk, meat, etc. Long noncoding RNA (lncRNA) is defined as longer than 200 bp in non-protein coding transcripts. lncRNA known to function regulating gene expression and currently being studied a variety livestock including cattle. The purpose this study analyze characteristics according sex Hanwoo cattle.Methods: This was conducted using skeletal muscles 9 cattle include bulls, steers cows. extracted from...