A5028092000- Animal Genetics and Reproduction
- Animal Nutrition and Physiology
- Probiotics and Fermented Foods
- RNA Interference and Gene Delivery
- Gut microbiota and health
- CRISPR and Genetic Engineering
- Antimicrobial Peptides and Activities
- Genetic and phenotypic traits in livestock
- Virus-based gene therapy research
- Epigenetics and DNA Methylation
- Metabolomics and Mass Spectrometry Studies
- Reproductive Biology and Fertility
- Spine and Intervertebral Disc Pathology
- Cervical and Thoracic Myelopathy
- Spinal Fractures and Fixation Techniques
- Ginseng Biological Effects and Applications
- Aquaculture disease management and microbiota
- Polydiacetylene-based materials and applications
- Skin Protection and Aging
- Organic Light-Emitting Diodes Research
- melanin and skin pigmentation
- Transgenic Plants and Applications
- Pharmacological Effects of Natural Compounds
- Nuclear Receptors and Signaling
- Nanocluster Synthesis and Applications
Chung-Ang University
2023-2025
Korea Food Research Institute
2024
Yonsei University
2022-2024
Hanbat National University
2024
Gangnam Severance Hospital
2022-2024
Rutgers, The State University of New Jersey
2024
Korea Institute of Oriental Medicine
2024
Ulsan National Institute of Science and Technology
2023
Korea Advanced Institute of Science and Technology
2023
Jeonbuk National University
2017-2022
Abstract Rice (Oryza sativa), a monocotyledonous plant that does not cold acclimate, has evolved differently from Arabidopsis (Arabidopsis thaliana), which acclimates. To understand the stress response of rice in comparison with Arabidopsis, we developed transgenic plants constitutively expressed CBF3/DREB1A (CBF3) and ABF3, genes function abscisic acid-independent acid-dependent stress-response pathways, respectively. CBF3 elevated tolerance to drought high salinity, produced relatively low...
The removal of dying cells, or efferocytosis, is an indispensable part resolving inflammation. However, the inflammatory microenvironment atherosclerotic plaque frequently affects biology both apoptotic cells and resident phagocytes, rendering efferocytosis dysfunctional. To overcome this problem, a chimeric antigen receptor (CAR) macrophage that can target engulf phagocytosis-resistant expressing CD47 developed. In normal circumstances, CAR macrophages exhibit activity equivalent to...
Host defence peptides are a diverse group of small, cationic and important elements the first line defense against pathogens in animals. Expression functional analysis host has been evaluated chicken but there no direct, comprehensive comparisons with all gene family individual genes. We examined expression patterns known cathelicidins, β-defensins NK-lysin multiple selected tissues from chickens. CATH1 through 3 were predominantly expressed bone marrow, whereas CATHB1 was predominant bursa...
Human breast milk (HBM)-derived exosomes play a crucial role not only in infant nutrition but also modulating inflammation, immunity, and epithelial cell protection. This study investigated how HBM-derived regulate immune development function. The promoted the differentiation of naïve CD4+ T cells into Treg Th2 while suppressing their Th17 Th1 cells. They enhanced proliferation intestinal Caco-2 reduced apoptosis dextran sulfate sodium (DSS)-damaged caco-2 In DSS-induced colitis mouse model,...
NK-lysin is an effector protein of the innate immune system and important component host protection. We isolated a SNP in coding sequence among different chicken breeds. This A to G substitution at position 271 nucleotide ORF results Asn (N) Asp (D) amino acid alteration. synthesized two 30-aa peptides (N29N N29D) compare biological activity helix 2-loop-helix 3 region resulting from polymorphic gene. Both were found be cytotoxic bacteria tumor cell cultures micromolar concentrations. The...
There have been numerous investigations regarding various types of dressings and artificial dermis solid form, yet limited research development on paste types, such as hydrogels with dermal powder, ensued. In this study, we compared the in vivo wound healing effects gelatin containing powder to a collagen type I/chondroitin 6-sulfate (coll/chondroitin) sponge alone, after 48 days post grafting, skin rat model. powder/gelatin paste-treated group, area contraction was minimized 50%, while...
This study utilized cellulose-based external light extraction films to enhance the outcoupling efficiency of organic light-emitting diodes (OLEDs). These were created through a straightforward fabrication employing biopolymers hydroxyethyl cellulose (HEC) and tannic acid (TA). We observed that hydrogen bonding between HEC TA could spontaneously generate random microtextured surface on HEC: films. Furthermore, morphology HECTA film can be adjusted by varying content. When applying as an...
Oviduct-specific expression of heterologous recombinant proteins in transgenic birds is a promising technology for the large-scale production therapeutic eggs. We describe human interleukin 1 receptor antagonist (rhIL1RN) eggs quails. To drive tissue-specific rhIL1RN, 1.35-kb fragment chicken ovalbumin promoter, which contains both steroid-dependent regulatory element and negative element, was used. A quail generated by microinjection concentrated stock lentivirus into stage X blastodermal...
Fermented black ginseng (FBG) is processed by the repeated steaming and drying of fresh followed fermentation with Saccharomyces cerevisiae. It known to possess anti‑oxidative effects. Skin wrinkle formation associated oxidative stress inflammatory reactions. The aim this study was determine whether FBG possesses anti‑wrinkle activity using human fibroblasts (HS68). According Korea Ministry Food Drug Safety (MFDS) guidelines for evaluation efficacy functional cosmetics, we attempted...
Probiotics can modulate the composition of gut microbiota and benefit host animal health in multiple ways. Lactic acid bacteria (LAB), mainly Lactobacillus Bifidobacterium species, are well-known microbes with probiotic potential. In present study, 88 microbial strains were isolated from canine feces annotated. Among these, four CACC517, 537, 558, 566 tested for characteristics, their beneficial effects on hosts evaluated both vitro vivo ; these exhibited antibiosis, antibiotic activity,...
Skeletal muscle can be ultrastructurally damaged by eccentric exercise, and the damage causes metabolic disruption in muscle. This study aimed to determine changes metabolomic patterns urine markers after exercise. Five men 6 women aged 19~23 years performed 30 min of bench step exercise at 70 steps per a determined height 110% lower leg length, stepping frequency 15 cycles min. 1H NMR spectral analysis was collected from all participants before exercise-induced conventionally using visual...
The antimicrobial peptides (AMP) are important elements of the first line defense against pathogens in animals, and an constituent innate immunity. Antimicrobial act on a broad spectrum microbial organisms. NK-Lysin is cationic antibacterial peptide that was originally isolated from porcine intestinal tissue based its activity. We synthesized corresponding to each helical region chicken NK-lysin analyzed their secondary structures addition Circular dichroism spectroscopy synthetic (cNK-78) 4...
A lab-on-a-chip (LOC) is a microfluidic device (MFD) that integrates several lab functions into single chip of only millimeters in size. LOC provides advantages, such as low fluidic volumes consumption, faster analysis, compactness, and massive parallelization. These properties enable microfluidic-based high-throughput drug screening (HTDS) system to acquire cell-based abundant cytotoxicity results depending on linear gradient concentration with few hundreds microliters the drug. Therefore,...
Objective Evaluation of exercise effects in racehorses is important horseracing industry and animal health care. In this study, we compared metabolic patterns between before after to screen biomarkers for thoroughbreds. Methods The concentration metabolites muscle, plasma, urine was measured by 1H nuclear magnetic resonance (NMR) spectroscopy analysis the relative metabolite levels three samples were exercise. Subsequently, multivariate data based on profiles performed using orthogonal...
We investigated S-adenosylhomocysteine hydrolase-like protein 1 ( AHCYL1) gene expression in human epithelial ovarian cancer (EOC) using the chicken, which is most relevant animal model. Ovarian was detected 10 of 136 laying hens (7.4%). Results present study indicated that AHCYL1 mRNA and are abundant glandular epithelium adenocarcinoma cancerous, but not normal, ovaries hens. In addition, bisulfite sequencing to examine methylation patterns promoter region revealed 30–38% three CpG sites...