A5015098626- Contact Dermatitis and Allergies
- Advancements in Transdermal Drug Delivery
- Effects and risks of endocrine disrupting chemicals
- Animal testing and alternatives
- Skin Protection and Aging
- Dyeing and Modifying Textile Fibers
- Carcinogens and Genotoxicity Assessment
- melanin and skin pigmentation
- Technology and Data Analysis
- Tea Polyphenols and Effects
- Advanced Glycation End Products research
- Anesthesia and Neurotoxicity Research
- Ginseng Biological Effects and Applications
- Forensic Toxicology and Drug Analysis
- Psychedelics and Drug Studies
- Biopolymer Synthesis and Applications
- Autism Spectrum Disorder Research
- Muscle metabolism and nutrition
- Occupational exposure and asthma
- Pharmacological Effects and Toxicity Studies
- Antimicrobial agents and applications
- Exercise and Physiological Responses
- Biological Stains and Phytochemicals
- Fermentation and Sensory Analysis
- Cannabis and Cannabinoid Research
Dankook University
2020-2024
Sungkyunkwan University
2014-2020
Kangwon National University
2010
Skeletal muscle can be ultrastructurally damaged by eccentric exercise, and the damage causes metabolic disruption in muscle. This study aimed to determine changes metabolomic patterns urine markers after exercise. Five men 6 women aged 19~23 years performed 30 min of bench step exercise at 70 steps per a determined height 110% lower leg length, stepping frequency 15 cycles min. 1H NMR spectral analysis was collected from all participants before exercise-induced conventionally using visual...
Disposable sanitary pads are a necessity for women's health, but safety concerns regarding the use of these products have created anxiety. The aim this study was to conduct risk assessment 74 volatile organic compounds (VOCs), which were expected be contained within pads. Of VOCs, 50 found in retailed Korea at concentrations ranging from 0.025 3548.09 µg/pad. In order undertake toxicological database United States Environmental Protection Agency (USEPA), Toxic Substances and Disease Registry...
Abstract DNA nanostructures have been widely studied in biomedical research contributing to targeted treatment of chronic diseases. The immunostimulatory X L ‐DNA X‐shaped oligodeoxynucleotides complex are previously reported, activating toll‐like receptor9 dendritic cells. This study examines whether the could be therapeutically applied treat immune diseases such as atopic dermatitis. To optimize topical delivery, liposome‐encapsulated (Lipo‐X ‐DNA) is generated using emulsion transfer...
Cisplatin (CP) is an anti-cancer drug used for treatment of solid tumors, but the major adverse effect drug-induced nephrotoxicity. The current study aimed to determine biomarkers that might predict nephrotoxicity induced by CP using serum or urinary proton nuclear magnetic resonance (1H NMR) spectral data in male Sprague-Dawley (S-D) rats. (0, 0.5 5 mg/kg) was intraperitoneally (i.p.) administered single dose. Animals were sacrificed 2 days (D2) 8 (D8) after administration order perform...
Dermal absorption of chemicals is a key factor in risk assessment. This study investigated the effects different amounts application on dermal and suggested an appropriate dose for proper absorption. Caffeine testosterone were chosen as test compounds. An vitro was performed using Franz diffusion cell. Different (5, 10, 25, 50 mg (or µL)/cm2) semisolid (cream) liquid (solution) formulations containing 1% caffeine 0.1% applied to rat minipig (Micropig®) skins. After 24 h, concentrations both...
Dry eye disease (DED) is a chronic and progressive lesion on the ocular surface induces symptoms, such as burning sensation, itchy eyes, heavy tired dry feeling, facial flushing, blurred vision. The present study was performed to develop DED biomarkers using metabolomics in rat model. induced by injecting scopolamine exposing rats condition. Scopolamine (12 mg/kg/day for 7 days) subcutaneously injected male Sprague–Dawley rats. were placed condition with air-flow dehumidifier. Tear volume...
Prenatal exposure to valproic acid (VPA) has been implicated in the manifestation of autism spectrum disorder (ASD)-like behavioral and functional changes both human rodents including mice rats. The objective this study was determine metabolomics profiling biomarkers related VPA-induced symptoms resembling ASD using proton nuclear magnetic resonance (1H-NMR) spectral data. VPA administered pregnant rats at gestation day 12.5 effects measured subsequently male 4-week-old offspring pups....
Dry eye disease (DED) is an ophthalmic associated with poor quality and quantity of tears, the number patients steadily increasing. The aim this study was to determine plasma urine metabolites obtained from DED scopolamine animal model where dry conditions (DRY) are induced. It also interest examine whether (scopolamine) rat exacerbated by treatment benzalkonium chloride (BAC). Subsequently, were analyzed using liquid chromatography (LC) gas (GC)-mass spectrometry (MS), respectively. Data...
The aim of this study was to determine the effects anti-wrinkle and skin-whitening fermented black ginseng (FBG) in human subjects examine underlying biochemical mechanisms action. A clinical performed evaluate efficacy safety using a 1% FBG cream formulation. Twenty-three were recruited instructed apply control or creams each on half their face twice daily for 8 weeks. After weeks, significantly reduced appearance eye wrinkles compared prior exposure cream. Skin color brightened comparison...
HAase는 신체의 연골, 피부, 눈의 초자체 등에 포함된 고분자 다당류의 HA를 분해하는 효소로서 상처나 염증질환 시 활성화되어 염증, 알레르기 유발과 관련된 효소이다. 본 연구는 500종 식물에서 각 종당 한 식물체로부터 천연물의 메탄올 추출물(500추출물)을 이용하여 생물학적으로 기능이 다양하고 산업적으로 활용 가능성이 많은 HAase 저해제를 검색하였다. 그 결과 저해효과가 가장 우수한 천연물 추출물은 때죽나무 줄기 추출물 57.28%, 매화말발도리 53.50%의 저해효과를 나타내었다. 이 같은 추출물들의 농도 별 확인한 의존적으로 저해율이 증가하였다. 결과로 볼 때 때죽나무, 효소의 우수하여 향후 HA 분해와 항염증 및 항 연구에 이용될 수 있다. Mammalian hyaluronidases (HAase, EC 3.2.1.35) are a family of enzymes that hydrolyse N-acetyl-D-glucosamine (1-4) glycosidic...
3,4-Methylenedioxy-N-methamphetamine (MDMA, ecstasy) is an amphetamine derivative and a popular type of drug that abused due to its effects on the central nervous system (CNS), including alertness euphoria. However, life-threatening (brain edema, heart failure, coma) fatal hyperthermia sometimes occur in some individuals taking MDMA. In one-generation reproductive toxicity study, potential chronic exposure MDMA was investigated capabilities parental mice (F0), as well survival/development...
The aim of this study was to determine the effects anti-wrinkle and skin-whitening fermented black ginseng (FBG) in human subjects examine underlying biochemical mechanisms action. A clinical performed evaluate efficacy safety using a 1% FBG cream formulation. Twenty-three were recruited instructed apply control or creams each on half their face twice daily for 8 weeks. After weeks significantly reduced appearance eye wrinkles compared prior exposure cream. Skin color brightened comparison...
Propylidene phthalide (PP) is a cosmetic ingredient used in the fragrance industry and regulated for limited content of 0.01% products Korea. The aim this study was to determine PP dermal absorption rate according Korea Ministry Food Drug Safety (MFDS) guidelines using vitro Franz diffusion system. An analytical method assessing developed through validation LC–MS/MS. Linearity, precision, accuracy were acceptable based upon MFDS guidelines. stability receptor fluid (50% ethanol) at 32°C...
The chemical 4-amino-3-nitrophenol (4A3NP) is classified as an amino nitrophenol and primarily utilized ingredient in hair dye colorants. In Korea Europe, it exclusively used non-oxidative or oxidative formulations, with maximum allowable concentrations of 1% 1.5%, respectively. Despite this widespread use, risk assessment 4A3NP has not been completed due to the lack proper dermal absorption data. Therefore, study, both analytical method validation vitro study were conducted following...
Recently, the demand for safety in industrial facilities has been increasing, and many studies are being conducted. However, there is not much research on multi-use facilities. In practice, a tendency to focus more than due economic importance, complex technical issues, compliance with legal regulations standards, concentration of resources. This study focuses management Multi-use play an important role preventing managing potential risks accidents used by people. facilities, which public...
AbstractBepotastine salts (nicotinate and salicylate) were investigated for their physicochemical properties to develop novel salt forms of bepotastine, bioequivalent the bepotastine besilate-loaded tablet (Talion). These either nicotinate- or salicylate-loaded tablets prepared by conventional wet granulation method, dissolution profiles pharmacokinetics in beagle dogs compared those Talion. A nicotinate has a higher solubility at varying pH levels (1.2, 4, 6.8) than salt. In addition,...