A5091417501- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Inflammasome and immune disorders
- Virus-based gene therapy research
- Dendrimers and Hyperbranched Polymers
- Gout, Hyperuricemia, Uric Acid
- Ubiquitin and proteasome pathways
- DNA and Nucleic Acid Chemistry
- Advanced Nanomaterials in Catalysis
- Extracellular vesicles in disease
- interferon and immune responses
- Polymer Surface Interaction Studies
- Pancreatic function and diabetes
- Photodynamic Therapy Research Studies
- Advanced Drug Delivery Systems
- Lipid Membrane Structure and Behavior
- Drug-Induced Hepatotoxicity and Protection
- Dermatology and Skin Diseases
- Pharmacogenetics and Drug Metabolism
- Biopolymer Synthesis and Applications
- RNA Research and Splicing
- Melanoma and MAPK Pathways
- Piperaceae Chemical and Biological Studies
Catholic University of Korea
2016-2025
Sichuan University
2014-2025
Bucheon St. Mary's Hospital
2018-2024
Heidelberg University
2023
Bucheon University
2016
Government of the Republic of Korea
2014-2016
State Key Laboratory of Biotherapy
2014
University of Utah
2005-2012
Yonsei University
2005-2010
Inje University Sanggye Paik Hospital
2007
Piezoelectric nanomaterials that can generate reactive oxygen species (ROS) by piezoelectric polarization under an external mechanical force have emerged as effective platform for cancer therapy. In this study, 2D WS2 nanosheets are functionalized with mitochondria-targeting triphenylphosphonium (TPP) ultrasound (US)-triggered, mitochondria-targeted piezodynamic addition, a glycolysis inhibitor (FX11) inhibit cellular energy metabolism is loaded into TPP- and poly(ethylene glycol)...
Sonodynamic therapy (SDT), wherein sonosensitizers irradiated with ultrasound (US) produce cytotoxic reactive oxygen species (ROS), has garnered great attention as a promising alternative to photodynamic owing the significantly increased depth of tissue penetration. The development nanocarriers that can selectively deposit into tumor tissues without systemic toxicity is crucial facilitate translation SDT clinical use. In this study, exosomes, class naturally occurring nanoparticles, were...
Tumor microenvironment favors tumor cells to promote their growth and metastasis such as migration, invasion, angiogenesis. IL-1β, one of the inflammatory cytokines released from myeloid in microenvironment, plays an important role development progress tumor. The activation inflammasome is a critical step secrete mature IL-1β through stepwise reactions activate capspase-1. Therefore, we investigated whether inhibition NACHT, LRR PYD domains-containing protein 3 (NLRP3) macrophages regulated...
Objective The NLRP 3 inflammasome is closely linked to the pathophysiology of a wide range inflammatory diseases. This study was undertaken identify small molecules that directly bind in order develop pharmacologic interventions for 3‐related Methods A structure‐based virtual screening analysis performed with ~62,800 compounds select efficient inhibitors. production caspase 1‐p10 and interleukin‐1β ( IL ‐1β) measured by immunoblotting enzyme‐linked immunosorbent assay examine activation. Two...
Glioblastoma (GBM) is the most aggressive malignant brain tumor and has a high mortality rate. Photodynamic therapy (PDT) emerged as promising approach for treatment of tumors. However, use PDT GBM been limited by its low blood‒brain barrier (BBB) permeability lack cancer-targeting ability. Herein, endothelial cell-derived extracellular vesicles (bEVs) were used biocompatible nanoplatform to transport photosensitizers into tumors across BBB. To enhance efficacy, photosensitizer chlorin e6...
For mitochondria‐targeting delivery, a coupling reaction between poly(ε‐caprolactone) diol (PCL diol) and 4‐carboxybutyltriphenylphosphonium (4‐carboxybutyl TPP) results in the synthesis of amphiphilic TPP‐PCL‐TPP (TPCL) polymers with bola‐like structure. In aqueous environments, TPCL polymer self‐assembled via cosolvent dispersion film hydration, resulting formation cationic nanoparticles (NPs) less than 50 nm size zeta‐potentials approximately 40 mV. Interestingly, different preparation...
The aetiology of gout is closely linked to the deposition monosodium uric acid (MSU) crystals and consequent activation NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome. In this study, we investigated whether oral administration an NLRP3 inhibitor would be effective attenuate symptoms gout. effects with sulforaphane (SFN) were examined in two mouse models acute induced by injection MSU into footpads or air pouch. production caspase-1 (p10) IL-1β was immunoblotting...
Abstract Rheumatoid arthritis (RA) is a systemic inflammatory disease that mainly affects the synovial joints. Although involvement of fibroblast growth factor (FGF) signaling pathway has been suggested as an important modulator in RA development, no clear evidence provided. In this study, we found fluid basic FGF (bFGF) concentration was significantly higher than osteoarthritis (OA) patients. bFGF stimulates proliferation and migration human fibroblast-like synoviocytes (FLSs) by activation...
Gout is a chronic inflammatory disease evoked by the deposition of monosodium urate (MSU) crystals in joint tissues. The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin containing 3 (NLRP3) inflammasome responsible for gout symptoms induced MSU crystals. We investigated whether epigallocatechin-3-gallate (EGCG) suppresses activation NLRP3 inflammasome, thereby effectively preventing gouty inflammation. EGCG blocked crystal-induced production caspase-1(p10)...
Non-alcoholic steatohepatitis (NASH), a type of non-alcoholic fatty liver disease, is characterized as steatosis and inflammation in the liver. NLRP3 inflammasome activation associated with NASH pathology. We hypothesized that suppressing could be effective preventing NASH. searched substances inhibit identified sweroside an inhibitor. investigated whether can applied to prevent pathological symptoms methionine–choline-deficient (MCD) diet-induced mouse model. The was determined by detecting...
By mimicking natural lubricin, a tailored polyzwitterionic armor, which exhibited cartilage targeting, anti-degradation and anti-oxidation chondrogenesis properties, was designed for drug-free osteoarthritis therapy.
Abstract Oligomeric sulfonamides (OSAs) are explored as a tool for the effective endosomal release of polyplexes or delivery nucleic acid. The OSAs tested in this study show varying proton‐buffering regions and pH‐dependent solubility transitions within pH range, influenced by p K value hydrophobicity given sulfonamide group. In addition, OSA presents negligible toxicity. oligomers added to acid solution polyplex formation with positively charged polymeric carriers. resulting nanoscale,...