A5103184113- Carcinogens and Genotoxicity Assessment
- Air Quality and Health Impacts
- Antimicrobial agents and applications
- Toxic Organic Pollutants Impact
- Effects and risks of endocrine disrupting chemicals
- Energy and Environment Impacts
- Molecular Biology Techniques and Applications
- Gene expression and cancer classification
- Occupational exposure and asthma
- Epigenetics and DNA Methylation
- Indoor Air Quality and Microbial Exposure
- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- Asthma and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Biosensors and Analytical Detection
- Biopolymer Synthesis and Applications
- Cancer, Hypoxia, and Metabolism
- Chemical Reactions and Isotopes
- MicroRNA in disease regulation
- Environmental Toxicology and Ecotoxicology
- Metabolomics and Mass Spectrometry Studies
- Microplastics and Plastic Pollution
- Genomics, phytochemicals, and oxidative stress
- Computational Drug Discovery Methods
Korea Institute of Toxicology
2017-2025
Xuzhou University of Technology
2024
Chungnam National University
2023
Korea University of Science and Technology
2019-2022
Korea Basic Science Institute
2021
Bio-Medical Science (South Korea)
2020
Korea Institute of Science and Technology
2010-2016
Korea University
2011-2012
Abstract Background The respiratory system is exposed to various allergens via inhaled and intranasal routes. Murine models of allergic lung disease have been developed clarify the mechanisms underlying inflammatory responses evaluate efficacy novel therapeutics. However, there no comparative studies on differences in phenotypes following vs. allergen challenge. In this study, we compared asthmatic features mice challenged different routes sensitization investigated mechanisms. Methods To...
Airway inflammation plays a central role in the pathophysiology of diverse pulmonary diseases. In this study, we investigated whether exposure to particulate matter (PM) 2.5, PM with an aerodynamic diameter less than 2.5 µm, enhances inflammation-related toxicity human respiratory system through activation epidermal growth factor receptor (EGFR) signaling pathway. Through cytokine antibody array analysis two extracts PM2.5 [water (W-PM2.5 ) and organic (O-PM2.5 soluble extracts] exposed A549...
Diesel exhaust particulates (DEP) have adverse effects on the respiratory system. Endoplasmic reticulum (ER) abnormalities contribute to lung inflammation. However, relationship between DEP exposure and ER stress in immune system especially alveolar macrophages (AM) is poorly understood. Here, we examined inflammatory responses using both vivo vitro study. For study, mice were intratracheally instilled with 25, 50, 100 μg AM stimulated at 1, 2, 3 mg/mL. increased weight number of cells,...
MicroRNA (miRNA) is now attracting attention as a powerful negative regulator of messenger RNA(mRNA) levels, and implicated in the modulation important mRNA networks involved toxicity. In this study, we assessed effects particulate matter 2.5 (PM2.5 ), one most significant air pollutants, on miRNA target gene expression. We exposed human alveolar epithelial cell (A549) to two types PM2.5 [water (W-PM2.5 ) organic (O-PM2.5 soluble extracts] performed microarray analysis. A total 37 miRNAs 62...
Hexanal is a major component of indoor air pollutants and kind aldehydes; it has adverse effects on human health. We performed an in vivo inhalation study transcriptomic analysis to determine the mode toxic actions response hexanal. Fischer 344 rats both sexes were exposed by hexanal aerosol for 4 h day-1 , 5 days week-1 weeks at 0, 600, 1000, 1500 ppm. Throughout our microarray-based genome-wide expression analysis, we identified 56 differentially expressed genes three doses hexanal; among...
Currently available toxicity data on humidifier disinfectants are primarily limited to polyhexamethylene guanidine phosphate-induced lung fibrosis. We, therefore, investigated whether the sterilizer component Kathon, which is a mixture of chloromethylisothiazolinone and methylisothiazolinone, induces fibrotic injury following direct exposure in an animal model. Mice were intratracheally instilled with either vehicle or Kathon. Differential cell counts, cytokine analysis, histological...
Diesel exhaust particulates (DEP) adversely affect the respiratory system and exacerbate lung diseases, resulting in high mortality rates. However, its pathogenesis is complicated, mechanisms involved are incompletely understood. We investigated effects of DEP pre-exposure on lipopolysaccharide (LPS)-induced acute injury (ALI) identified roles interleukin (IL)-17 mice. Mice were divided into vehicle control, DEP, LPS, pre-exposed LPS-instilled groups. Pre-exposure to enhanced number total...
No comparative study has yet been performed on the respiratory effects of individual E-cigarette ingredients. Here, lung toxicity ingredients products containing nicotine or tetrahydrocannabinol was investigated. Mice were intratracheally administered propylene glycol (PG), vegetable glycerin (VG), vitamin E acetate (VEA), individually for two weeks. Cytological and histological changes noticed in PG- VEA-treated mice that exhibited pathophysiological which associated with symptoms seen...
In the current study, we aimed to investigate transcriptomic responses and identify specific molecular signatures of low-molecular-weight saturated aliphatic aldehydes (LSAAs). To evaluate change in gene expression levels, A549 human alveolar epithelial cells were exposed six LSAAs (propanal, butanal, pentanal, hexanal, heptanal, octanal) for 48 h. Clustering analysis data show that low carbon number group (LCG; propanal, pentanal) was distinguished from high (HCG; octanal). Also, profiling...
Inhalation of diesel exhaust particulate (DEP) causes oxidative stress-induced lung inflammation. This study investigated the protective effects TF-343, an antioxidant and anti-inflammatory agent, in mouse cellular models DEP-induced inflammation as well underlying molecular mechanisms. Mice were intratracheally instilled with DEP or vehicle (0.05% Tween 80 saline). TF-343 was orally administered for 3 weeks. Cell counts histological analysis tissue showed that exposure increased...
Benzylalkyldimethylammonium chloride (BAC), a quaternary ammonium compound (QAC), is utilized in industrial and biomedical applications for antimicrobial purposes. Since the coronavirus disease (COVID-19) outbreak, various types of BAC-containing household chemicals have been produced. BACs several adverse effects; however, their biological uptake, translocation, excretion animal models (essential better understanding vivo behavior toxicological impact) remain unclear. In this study, we...
Particulate matter the environmental toxicant, with a diameter less than or equal to 2.5 μm (PM2.5 ) is common cause of several respiratory diseases. In recent years, studies have suggested that PM2.5 can influence diverse diseases, such as cardiovascular metabolic dementia, and female reproductive disorders, unhealthy birth outcomes. addition, epidemiological reported adverse health effects differ depending on regional variations. present study, evaluate specific , we collected two...
Thyroid peroxidase (TPO) plays an important role in thyroid hormone biosynthesis, as it catalyzes all of the essential steps iodide organification. TPO activity can be detected using guaiacol assay; however, this assay is complex and very time-consuming. Therefore, we focused on devising a simplified method microarrays to detect changes activity, which target for disruption axis. These experiments have systematically assessed potential utility transcriptomic end points enhancements assay....